Induction of pluripotent stem cells from adult human fibroblasts by defined factors | Cell | 2007 | 14.8K |
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells | Molecular and Cellular Biology | 1982 | 8.2K |
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells | Nature | 2001 | 7.8K |
WAF1, a potential mediator of p53 tumor suppression | Cell | 1993 | 7.4K |
Genome engineering using the CRISPR-Cas9 system | Nature Protocols | 2013 | 6.2K |
Rapid and efficient site-specific mutagenesis without phenotypic selection | Proceedings of the National Academy of Sciences of the United States of America | 1985 | 6K |
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine | Proceedings of the National Academy of Sciences of the United States of America | 1995 | 5.4K |
High-efficiency transformation of mammalian cells by plasmid DNA | Molecular and Cellular Biology | 1987 | 5.3K |
Pattern recognition receptors and inflammation | Cell | 2010 | 5.3K |
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases | Cell | 1993 | 5.1K |
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing | EMBO Journal | 2000 | 5K |
Rapid and efficient site-specific mutagenesis without phenotypic selection | Methods in Enzymology | 1987 | 4.9K |
Efficient selection for high-expression transfectants with a novel eukaryotic vector | Gene | 1991 | 4.5K |
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure | Proceedings of the National Academy of Sciences of the United States of America | 1987 | 4.3K |
Real time quantitative PCR | Genome Research | 1996 | 4.2K |
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? | Nature Reviews Genetics | 2008 | 4K |
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs | Nature | 2005 | 4K |
The nuclear RNase III Drosha initiates microRNA processing | Nature | 2003 | 3.9K |
Role for a bidentate ribonuclease in the initiation step of RNA interference | Nature | 2001 | 3.8K |
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis | Cell | 1998 | 3.7K |
A simplified system for generating recombinant adenoviruses | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 3.2K |
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy | Journal of Biological Chemistry | 2007 | 3.1K |
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 | Nature Cell Biology | 2008 | 3.1K |
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses | Nature Immunology | 2004 | 3K |
MicroRNA targeting specificity in mammals: determinants beyond seed pairing | Molecular Cell | 2007 | 3K |