27
Articles
2.1K
Citations
8.3
avg. Impact Factor
13
h-index

Most Cited Articles of Department of Medical Biochemistry and Biophysics

TitleJournalYearCitations
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assayScience2013982
Tracking cancer drugs in living cells by thermal profiling of the proteomeScience2014526
Understanding transport by the major facilitator superfamily (MFS): structures pave the wayNature Reviews Molecular Cell Biology2016214
The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker StudiesAnnual Review of Pharmacology and Toxicology2016156
Engineering protein thermostability using a generic activity-independent biophysical screen inside the cellNature Communications201363
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatasesStructure201435
Cholesterol-Enriched Domain Formation Induced by Viral-Encoded, Membrane-Active Amphipathic PeptideBiophysical Journal201617
Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1PLoS ONE201217
The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factorNucleic Acids Research201316
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine MonophosphatePLoS ONE201515
Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolismPLoS ONE201215
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthaseJournal of Lipid Research201315
Nanobody mediated crystallization of an archeal mechanosensitive channelPLoS ONE201315
Structural and biophysical characterization of the cytoplasmic domains of human BAP29 and BAP31PLoS ONE201315
Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1Journal of Virology201513
Digital health professions education on chronic wound management: A systematic reviewInternational Journal of Nursing Studies202012
Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2APLoS ONE201411
Interaction between human BAP31 and respiratory syncytial virus small hydrophobic (SH) proteinVirology201510
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathyNature Communications202110
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of BrivudinePLoS ONE20159
High-resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpAFASEB Journal20129
The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activityFEBS Journal20168
Interaction, uptake, and processing of LbL-coated microcarriers by PMNsCytometry Part A: the Journal of the International Society for Analytical Cytology20117
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct SubstratesPLoS ONE20133
A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane.Proceedings of the National Academy of Sciences of the United States of America20222