| 1 | A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction | Nature Biotechnology | 2020 | 1,218 |
| 2 | Lessons from the host defences of bats, a unique viral reservoir | Nature | 2021 | 369 |
| 3 | Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia | Nature Communications | 2021 | 363 |
| 4 | Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study | Lancet Microbe, The | 2021 | 363 |
| 5 | Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2 | MBio | 2020 | 268 |
| 6 | The Lancet NCDI Poverty Commission: bridging a gap in universal health coverage for the poorest billion | Lancet, The | 2020 | 232 |
| 7 | Healthcare worker stress, anxiety and burnout during the COVID-19 pandemic in Singapore: A 6-month multi-centre prospective study | PLoS ONE | 2021 | 135 |
| 8 | Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 124 |
| 9 | The ecology and adaptive evolution of influenza A interspecies transmission | Influenza and Other Respiratory Viruses | 2017 | 117 |
| 10 | Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles | PLoS Pathogens | 2020 | 112 |
| 11 | Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection | JAMA Network Open | 2022 | 98 |
| 12 | Caring for Children and Adolescents With Eating Disorders in the Current Coronavirus 19 Pandemic: A Singapore Perspective | Journal of Adolescent Health | 2020 | 93 |
| 13 | From Hendra to Wuhan: what has been learned in responding to emerging zoonotic viruses | Lancet, The | 2020 | 78 |
| 14 | Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 72 |
| 15 | Burden of disease among the world’s poorest billion people: An expert-informed secondary analysis of Global Burden of Disease estimates | PLoS ONE | 2021 | 71 |
| 16 | WHO international standard for SARS-CoV-2 antibodies to determine markers of protection | Lancet Microbe, The | 2022 | 67 |
| 17 | A new Hendra virus genotype found in Australian flying foxes | Virology Journal | 2021 | 63 |
| 18 | IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation | Nature Immunology | 2022 | 62 |
| 19 | Cost-Effectiveness of Family-Based Group Treatment for Child and Parental Obesity | Childhood Obesity | 2014 | 58 |
| 20 | Risk factors and biomarkers of severe dengue | Current Opinion in Virology | 2020 | 57 |
| 21 | Consumption Of Specific Foods And Beverages And Excess Weight Gain Among Children And Adolescents | Health Affairs | 2015 | 53 |
| 22 | Bat ASC2 suppresses inflammasomes and ameliorates inflammatory diseases | Cell | 2023 | 53 |
| 23 | Decoding bat immunity: the need for a coordinated research approach | Nature Reviews Immunology | 2021 | 51 |
| 24 | SARS-CoV-2 Omicron variant emerged under immune selection | Nature Microbiology | 2022 | 47 |
| 25 | Outcomes of SARS-CoV-2–Positive Youths Tested in Emergency Departments | JAMA Network Open | 2022 | 46 |
| 26 | Determining optimal gestational weight gain in a multiethnic Asian population | Journal of Obstetrics and Gynaecology Research | 2014 | 44 |
| 27 | Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host | Proceedings of the National Academy of Sciences of the United States of America | 2022 | 44 |
| 28 | Effectiveness of mindfulness-based interventions on the well-being of healthcare workers: a systematic review and meta-analysis | Annals of General Psychiatry | 2024 | 40 |
| 29 | The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi | Nature Communications | 2022 | 38 |
| 30 | Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection | EMBO Molecular Medicine | 2022 | 36 |
| 31 | Evaluation of a surrogate virus neutralization test for high-throughput serosurveillance of SARS-CoV-2 | Journal of Virological Methods | 2021 | 35 |
| 32 | Neutralizing Activity and SARS-CoV-2 Vaccine mRNA Persistence in Serum and Breastmilk After BNT162b2 Vaccination in Lactating Women | Frontiers in Immunology | 2022 | 34 |
| 33 | Stressors and coping strategies of migrant workers diagnosed with COVID-19 in Singapore: a qualitative study | BMJ Open | 2021 | 33 |
| 34 | Artificial intelligence and digital health in improving primary health care service delivery in LMICs: A systematic review | Journal of Evidence-Based Medicine | 2023 | 33 |
| 35 | Developing an effective and sustainable national immunisation programme in China: issues and challenges | Lancet Public Health, The | 2022 | 32 |
| 36 | Adding Financial Incentives to Online Group-Based Behavioral Weight Control: An RCT | American Journal of Preventive Medicine | 2020 | 28 |
| 37 | Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection
In Vitro
, despite Eliciting a Prolonged Antiviral Response | MBio | 2022 | 28 |
| 38 | Incremental cost‐effectiveness of evidence‐based non‐surgical weight loss strategies | Clinical Obesity | 2019 | 27 |
| 39 | Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals | hLife | 2023 | 27 |
| 40 | Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea | Immunity | 2022 | 26 |
| 41 | Addressing cancer care in low- to middle-income countries: a call for sustainable innovations and impactful research | BMC Cancer | 2023 | 26 |
| 42 | Identification of a Lineage D Betacoronavirus in Cave Nectar Bats (Eonycteris spelaea
) in Singapore and an Overview of Lineage D Reservoir Ecology in SE Asian Bats | Transboundary and Emerging Diseases | 2017 | 25 |
| 43 | A survey of anxiety and burnout in the radiology workforce of a tertiary hospital during the COVID‐19 pandemic | Journal of Medical Imaging and Radiation Oncology | 2021 | 25 |
| 44 | Bat virome research: the past, the present and the future | Current Opinion in Virology | 2021 | 25 |
| 45 | Promises and challenges of mucosal COVID-19 vaccines | Vaccine | 2023 | 25 |
| 46 | Patient perspectives on hypertension management in health system of Sri Lanka: a qualitative study | BMJ Open | 2019 | 24 |
| 47 | MR1-Restricted T Cells with MAIT-like Characteristics Are Functionally Conserved in the Pteropid Bat Pteropus alecto | IScience | 2020 | 23 |
| 48 | Detection and genetic characterization of diverse Bartonella genotypes in the small mammals of Singapore | Zoonoses and Public Health | 2018 | 21 |
| 49 | Understanding the needs of health care workers in Singapore during the COVID-19 outbreak: A qualitative analysis | American Journal of Infection Control | 2022 | 21 |
| 50 | Harnessing Artificial Intelligence to Enhance Global Breast Cancer Care: A Scoping Review of Applications, Outcomes, and Challenges | Cancers | 2025 | 21 |