| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen | New England Journal of Medicine | 2000 | 4,827 |
| 2 | Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis | Stem Cells | 2007 | 1,496 |
| 3 | Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing | PLoS ONE | 2008 | 1,378 |
| 4 | Hepatitis C virus replication in mice with chimeric human livers | Nature Medicine | 2001 | 823 |
| 5 | Abbreviated Course of Radiation Therapy in Older Patients With Glioblastoma Multiforme: A Prospective Randomized Clinical Trial | Journal of Clinical Oncology | 2004 | 776 |
| 6 | Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease | Nature Communications | 2018 | 664 |
| 7 | A critical review of the long-term disability outcomes following hip fracture | BMC Geriatrics | 2016 | 599 |
| 8 | Transfusion-related acute lung injury: epidemiology and a prospective analysis of etiologic factors | Blood | 2003 | 590 |
| 9 | Sarcopenia in an Overweight or Obese Patient Is an Adverse Prognostic Factor in Pancreatic Cancer | Clinical Cancer Research | 2009 | 577 |
| 10 | Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge | Nature Medicine | 2008 | 561 |
| 11 | Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages | Nature Biotechnology | 2004 | 528 |
| 12 | Surgeon-Related Factors and Outcome in Rectal Cancer | Annals of Surgery | 1998 | 525 |
| 13 | Identification of tissue-specific cell death using methylation patterns of circulating DNA | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 508 |
| 14 | Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility | Circulation | 2007 | 494 |
| 15 | Infection and mortality of healthcare workers worldwide from COVID-19: a systematic review | BMJ Global Health | 2020 | 489 |
| 16 | Spatiotemporal evolution of ventricular fibrillation | Nature | 1998 | 485 |
| 17 | Local Anesthetics: Review of Pharmacological Considerations | Anesthesia Progress | 2012 | 477 |
| 18 | Early versus Late Parenteral Nutrition in Critically Ill Children | New England Journal of Medicine | 2016 | 424 |
| 19 | Induction Chemoradiation and Surgical Resection for Superior Sulcus Non–Small-Cell Lung Carcinomas: Long-Term Results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160) | Journal of Clinical Oncology | 2007 | 418 |
| 20 | Impact of Perioperative Systemic Steroids on Surgical Outcomes in Patients With Chronic Rhinosinusitis With Polyposis: Evaluation With the Novel Perioperative Sinus Endoscopy (POSE) Scoring System | Laryngoscope | 2007 | 404 |
| 21 | CD4 cells can be more efficient at tumor rejection than CD8 cells | Blood | 2007 | 378 |
| 22 | Optimal Perioperative Care in Major Head and Neck Cancer Surgery With Free Flap Reconstruction | JAMA Otolaryngology - Head and Neck Surgery | 2017 | 370 |
| 23 | HYPERTROPHIC SCARS, KELOIDS, AND CONTRACTURES | Surgical Clinics of North America | 1997 | 369 |
| 24 | Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis | Cell | 2000 | 359 |
| 25 | Long-Term Treatment With Oral Sildenafil Is Safe and Improves Functional Capacity and Hemodynamics in Patients With Pulmonary Arterial Hypertension | Circulation | 2003 | 343 |
| 26 | A Novel Grading Scale for the Angiographic Assessment of Intracranial Aneurysms Treated Using Flow Diverting Stents | Interventional Neuroradiology | 2010 | 342 |
| 27 | Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice | Diabetes | 2009 | 332 |
| 28 | Development and Initial Validation of a Risk Score for Predicting In-Hospital and 1-Year Mortality in Patients With Hip Fractures | Journal of Bone and Mineral Research | 2004 | 328 |
| 29 | Metabolic control of epigenetics in cancer | Nature Reviews Cancer | 2016 | 328 |
| 30 | Etiology and Clinical Course of Missed Spine Fractures | Journal of Trauma | 1987 | 316 |
| 31 | Reassessing selection criteria prior to liver transplantation for hepatocellular carcinoma utilizing the scientific registry of transplant recipients database | Hepatology | 2009 | 312 |
| 32 | Using the modified Delphi method to establish clinical consensus for the diagnosis and treatment of patients with rotator cuff pathology | BMC Medical Research Methodology | 2016 | 309 |
| 33 | A prevascularized subcutaneous device-less site for islet and cellular transplantation | Nature Biotechnology | 2015 | 307 |
| 34 | ‘It's on my iPhone’: attitudes to the use of mobile computing devices in medical education, a mixed-methods study | BMJ Open | 2012 | 299 |
| 35 | Delayed Graft Function in Renal Transplantation: Etiology, Management and Long-term Significance | Journal of Urology | 1996 | 292 |
| 36 | Effect of sleeve gastrectomy on gastroesophageal reflux disease: a systematic review | Surgery for Obesity and Related Diseases | 2011 | 290 |
| 37 | Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018 | International Journal of Stroke | 2018 | 286 |
| 38 | Effects of presurgical exercise training on cardiorespiratory fitness among patients undergoing thoracic surgery for malignant lung lesions | Cancer | 2007 | 284 |
| 39 | Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma | Hepatology | 2010 | 283 |
| 40 | VARIABLES IN ORGAN DONORS THAT AFFECT THE RECOVERY OF HUMAN ISLETS OF LANGERHANS1 | Transplantation | 1996 | 282 |
| 41 | Liver transplantation for “very early” intrahepatic cholangiocarcinoma: International retrospective study supporting a prospective assessment | Hepatology | 2016 | 280 |
| 42 | Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The “Anticipate” study | Hepatology | 2016 | 266 |
| 43 | p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion | Nature Medicine | 2016 | 262 |
| 44 | The Role of Obesity in Cancer Survival and Recurrence | Cancer Epidemiology Biomarkers and Prevention | 2012 | 254 |
| 45 | Bone marrow‐derived stem cells in wound healing: a review | Wound Repair and Regeneration | 2007 | 248 |
| 46 | Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration | Stem Cells | 2010 | 245 |
| 47 | Bridging children of all sizes to cardiac transplantation: The initial multicenter North American experience with the Berlin Heart EXCOR ventricular assist device | Journal of Heart and Lung Transplantation | 2011 | 245 |
| 48 | Endothelium-Derived Hyperpolarizing Factor in Human Internal Mammary Artery Is 11,12-Epoxyeicosatrienoic Acid and Causes Relaxation by Activating Smooth Muscle BK Ca Channels | Circulation | 2003 | 244 |
| 49 | Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma | Liver Transplantation | 2004 | 243 |
| 50 | Granzyme B: a natural born killer | Immunological Reviews | 2003 | 241 |
