| 1 | A systematic review of low back pain cost of illness studies in the United States and internationally | Spine Journal | 2008 | 1,370 |
| 2 | Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors | Clinics in Colon and Rectal Surgery | 2009 | 1,309 |
| 3 | Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention | Heliyon | 2018 | 870 |
| 4 | Click hydrogels, microgels and nanogels: Emerging platforms for drug delivery and tissue engineering | Biomaterials | 2014 | 619 |
| 5 | Predictive Factors, Management, and Clinical Outcomes of Coronary Obstruction Following Transcatheter Aortic Valve Implantation | Journal of the American College of Cardiology | 2013 | 476 |
| 6 | Patient Blood Management | JAMA - Journal of the American Medical Association | 2019 | 439 |
| 7 | Active Surveillance of Small Renal Masses: Progression Patterns of Early Stage Kidney Cancer | European Urology | 2011 | 334 |
| 8 | Systematic Classification of Morbidity and Mortality After Thoracic Surgery | Annals of Thoracic Surgery | 2010 | 309 |
| 9 | Calcific Tendinopathy of the Rotator Cuff: Pathogenesis, Diagnosis, and Management | Journal of the American Academy of Orthopaedic Surgeons, The | 1997 | 300 |
| 10 | Complex systems and the technology of variability analysis | Critical Care | 2004 | 276 |
| 11 | Internal plate fixation of fractures: short history and recent developments | Journal of Orthopaedic Science | 2006 | 270 |
| 12 | Emergency Medical Services Intervals and Survival in Trauma: Assessment of the “Golden Hour” in a North American Prospective Cohort | Annals of Emergency Medicine | 2010 | 260 |
| 13 | Mechanisms, Consequences, and Prevention of Coronary Graft Failure | Circulation | 2017 | 255 |
| 14 | Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit | New England Journal of Medicine | 2022 | 241 |
| 15 | Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models | IScience | 2021 | 236 |
| 16 | The Ottawa Surgical Competency Operating Room Evaluation (O-SCORE) | Academic Medicine | 2012 | 235 |
| 17 | Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold | Biomaterials | 2014 | 218 |
| 18 | Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score | Annals of Surgery | 2019 | 212 |
| 19 | Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts | Developmental Dynamics | 2010 | 204 |
| 20 | The Use of Platelet‐Rich Plasma in Arthroscopy and Sports Medicine: Optimizing the Healing Environment | Arthroscopy - Journal of Arthroscopic and Related Surgery | 2010 | 197 |
| 21 | Early versus late recurrence of intrahepatic cholangiocarcinoma after resection with curative intent | British Journal of Surgery | 2018 | 197 |
| 22 | Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: An Updated Consensus Approach from the Transatlantic Australasian RPS Working Group | Annals of Surgical Oncology | 2021 | 196 |
| 23 | Prehabilitation in adult patients undergoing surgery: an umbrella review of systematic reviews | British Journal of Anaesthesia | 2022 | 192 |
| 24 | BDNF and NT-3, but not NGF, Prevent Axotomy-induced Death of Rat Corticospinal NeuronsIn Vivo | European Journal of Neuroscience | 1996 | 189 |
| 25 | Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells | Cancer Research | 2013 | 186 |
| 26 | Frailty as a Predictor of Death or New Disability After Surgery | Annals of Surgery | 2020 | 181 |
| 27 | Very Early Recurrence After Liver Resection for Intrahepatic Cholangiocarcinoma | JAMA Surgery | 2020 | 175 |
| 28 | Lower limb biomechanics during gait do not return to normal following total hip arthroplasty | Gait and Posture | 2010 | 174 |
| 29 | Minimally Invasive Coronary Artery Bypass Grafting | Circulation | 2009 | 171 |
| 30 | Why are women deterred from general surgery training? | American Journal of Surgery | 2005 | 169 |
| 31 | Review and classification of variability analysis techniques with clinical applications | BioMedical Engineering OnLine | 2011 | 165 |
| 32 | STS/SCA/AmSECT/SABM Update to the Clinical Practice Guidelines on Patient Blood Management | Annals of Thoracic Surgery | 2021 | 165 |
| 33 | Valve sparing-root replacement with the reimplantation technique to increase the durability of bicuspid aortic valve repair | Journal of Thoracic and Cardiovascular Surgery | 2011 | 164 |
| 34 | Incidence of Lateral Femoral Cutaneous Nerve Neuropraxia After Anterior Approach Hip Arthroplasty | Clinical Orthopaedics and Related Research | 2010 | 162 |
| 35 | Comparison of coronary artery bypass surgery and percutaneous coronary intervention in patients with diabetes: a meta-analysis of randomised controlled trials | Lancet Diabetes and Endocrinology,the | 2013 | 159 |
| 36 | The Society for Vascular Surgery practice guidelines on follow-up after vascular surgery arterial procedures | Journal of Vascular Surgery | 2018 | 159 |
| 37 | Penile Prosthesis Surgery: Current Recommendations From the International Consultation on Sexual Medicine | Journal of Sexual Medicine | 2016 | 157 |
| 38 | Number and Station of Lymph Node Metastasis After Curative-intent Resection of Intrahepatic Cholangiocarcinoma Impact Prognosis | Annals of Surgery | 2021 | 155 |
| 39 | TRI-SCORE and benefit of intervention in patients with severe tricuspid regurgitation | European Heart Journal | 2024 | 155 |
| 40 | Femoroacetabular impingement alters hip and pelvic biomechanics during gait | Gait and Posture | 2009 | 153 |
| 41 | Effectiveness of Immersive Virtual Reality on Orthopedic Surgical Skills and Knowledge Acquisition Among Senior Surgical Residents | JAMA Network Open | 2020 | 153 |
| 42 | Cardiovascular progenitor–derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure | Journal of Heart and Lung Transplantation | 2016 | 151 |
| 43 | Continuous Multi-Parameter Heart Rate Variability Analysis Heralds Onset of Sepsis in Adults | PLoS ONE | 2009 | 150 |
| 44 | Break out of the Classroom: The Use of Escape Rooms as an Alternative Teaching Strategy in Surgical Education | Journal of Surgical Education | 2019 | 149 |
| 45 | Long-term Outcomes in Patients With Severely Reduced Left Ventricular Ejection Fraction Undergoing Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting | JAMA Cardiology | 2020 | 148 |
| 46 | Diagnosis of ventilator-associated pneumonia in critically ill adult patients—a systematic review and meta-analysis | Intensive Care Medicine | 2020 | 147 |
| 47 | Prosthesis–patient mismatch after aortic valve replacement predominantly affects patients with preexisting left ventricular dysfunction: Effect on survival, freedom from heart failure, and left ventricular mass regression | Journal of Thoracic and Cardiovascular Surgery | 2006 | 144 |
| 48 | Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis | Transfusion Medicine Reviews | 2019 | 140 |
| 49 | Contemporary outcomes of 2287 patients with bladder cancer who were treated with radical cystectomy: a Canadian multicentre experience | BJU International | 2011 | 139 |
| 50 | Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials | European Heart Journal | 2008 | 138 |
