| 1 | The social determinants of mental health and disorder: evidence, prevention and recommendations | World Psychiatry | 2024 | 686 |
| 2 | Adult mental health outcomes of adolescent depression: A systematic review | Depression and Anxiety | 2018 | 455 |
| 3 | Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta‐Analysis | Headache | 2015 | 260 |
| 4 | Ethnic and racial disparities in COVID-19-related deaths: counting the trees, hiding the forest | BMJ Global Health | 2020 | 228 |
| 5 | Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study | Gut | 2020 | 188 |
| 6 | Relationship between leisure time physical activity, sedentary behaviour and symptoms of depression and anxiety: evidence from a population-based sample of Canadian adolescents | BMJ Open | 2018 | 154 |
| 7 | Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery | JAMA - Journal of the American Medical Association | 2019 | 154 |
| 8 | State of the Science in Women's Cardiovascular Disease: A Canadian Perspective on the Influence of Sex and Gender | Journal of the American Heart Association | 2020 | 149 |
| 9 | Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017 | Injury Prevention | 2020 | 143 |
| 10 | Proposed subtypes of post‐COVID‐19 syndrome (or long‐COVID) and their respective potential therapies | Reviews in Medical Virology | 2022 | 134 |
| 11 | Good or best practice statements: proposal for the operationalisation and implementation of GRADE guidance | BMJ Evidence-Based Medicine | 2023 | 132 |
| 12 | Barriers to and enablers of diabetic retinopathy screening attendance: a systematic review of published and grey literature | Diabetic Medicine | 2018 | 124 |
| 13 | Sex Differences in Long‐Term Survival After Major Cardiac Surgery: A Population‐Based Cohort Study | Journal of the American Heart Association | 2019 | 116 |
| 14 | Biparametric vs multiparametric prostate magnetic resonance imaging for the detection of prostate cancer in treatment‐naïve patients: a diagnostic test accuracy systematic review and meta‐analysis | BJU International | 2019 | 109 |
| 15 | Knowledge and motivations of researchers publishing in presumed predatory journals: a survey | BMJ Open | 2019 | 105 |
| 16 | Accuracy of the Montreal Cognitive Assessment tool for detecting mild cognitive impairment: A systematic review and meta‐analysis | Alzheimer's and Dementia | 2023 | 104 |
| 17 | Effect of socio-demographic factors on the association between multimorbidity and healthcare costs: a population-based, retrospective cohort study | BMJ Open | 2017 | 100 |
| 18 | How the dual process model of human cognition can inform efforts to de‐implement ineffective and harmful clinical practices: A preliminary model of unlearning and substitution | Journal of Evaluation in Clinical Practice | 2018 | 100 |
| 19 | Awareness and interest in IQOS heated tobacco products among youth in Canada, England and the USA | Tobacco Control | 2020 | 98 |
| 20 | Cannabis‐based products for pediatric epilepsy: A systematic review | Epilepsia | 2019 | 97 |
| 21 | Inflammatory and vascular biomarkers in post‐COVID‐19 syndrome: A systematic review and meta‐analysis of over 20 biomarkers | Reviews in Medical Virology | 2023 | 94 |
| 22 | Exposure to ambient air pollution and the incidence of lung cancer and breast cancer in the Ontario Population Health and Environment Cohort | International Journal of Cancer | 2020 | 90 |
| 23 | Does breech delivery in an upright position instead of on the back improve outcomes and avoid cesareans? | International Journal of Gynecology and Obstetrics | 2017 | 89 |
| 24 | Rapid review methods more challenging during COVID-19: commentary with a focus on 8 knowledge synthesis steps | Journal of Clinical Epidemiology | 2020 | 89 |
| 25 | Can synthetic data be a proxy for real clinical trial data? A validation study | BMJ Open | 2021 | 89 |
| 26 | Effectiveness of implementation interventions in improving physician adherence to guideline recommendations in heart failure: a systematic review | BMJ Open | 2018 | 84 |
| 27 | Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta‐analysis | BJU International | 2018 | 81 |
| 28 | Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017 | Injury Prevention | 2020 | 81 |
| 29 | Rocuronium vs. succinylcholine for rapid sequence intubation: a Cochrane systematic review | Anaesthesia | 2017 | 80 |
| 30 | Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients | JAMA - Journal of the American Medical Association | 2019 | 80 |
| 31 | Association of Frailty and Long‐Term Survival in Patients Undergoing Coronary Artery Bypass Grafting | Journal of the American Heart Association | 2018 | 79 |
| 32 | Relationships between memory decline and the use of metformin or DPP4 inhibitors in people with type 2 diabetes with normal cognition or Alzheimer's disease, and the role APOE carrier status | Alzheimer's and Dementia | 2020 | 77 |
| 33 | Factors associated with attendance at screening for breast cancer: a systematic review and meta-analysis | BMJ Open | 2021 | 76 |
| 34 | The association between recreational cannabis legalization, commercialization and cannabis‐attributable emergency department visits in Ontario, Canada: an interrupted time–series analysis | Addiction | 2022 | 74 |
| 35 | Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study | Injury Prevention | 2020 | 71 |
| 36 | The effectiveness of eHealth interventions on physical activity and measures of obesity among working‐age women: a systematic review and meta‐analysis | Obesity Reviews | 2018 | 70 |
| 37 | Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations | BJOG: an International Journal of Obstetrics and Gynaecology | 2022 | 69 |
| 38 | Multicenter Emergency Department Validation of the Canadian Syncope Risk Score | JAMA Internal Medicine | 2020 | 68 |
| 39 | Mass Production of Systematic Reviews and Meta‐analyses: An Exercise in Mega‐silliness? | Milbank Quarterly | 2016 | 66 |
| 40 | Gene–environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta‐analyses of observational studies | International Journal of Cancer | 2019 | 66 |
| 41 | How has access to legal cannabis changed over time? An analysis of the cannabis retail market in Canada 2 years following the legalisation of recreational cannabis | Drug and Alcohol Review | 2022 | 66 |
| 42 | Life course health development of individuals with neurodevelopmental conditions | Developmental Medicine and Child Neurology | 2017 | 65 |
| 43 | Use of social media is associated with short sleep duration in a dose–response manner in students aged 11 to 20 years | Acta Paediatrica, International Journal of Paediatrics | 2018 | 64 |
| 44 | Spatial Abilities Training in Anatomy Education: A Systematic Review | Anatomical Sciences Education | 2020 | 64 |
| 45 | Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain: A Systematic Review and Meta‐analysis | Academic Emergency Medicine | 2019 | 60 |
| 46 | Defining predatory journals and responding to the threat they pose: a modified Delphi consensus process | BMJ Open | 2020 | 60 |
| 47 | Global prevalence of non-tuberculous mycobacteria in adults with non-cystic fibrosis bronchiectasis 2006–2021: a systematic review and meta-analysis | BMJ Open | 2022 | 60 |
| 48 | Brief interventions targeting long‐term benzodiazepine and Z‐drug use in primary care: a systematic review and meta‐analysis | Addiction | 2020 | 59 |
| 49 | Lactate Clearance as a Surrogate for Mortality in Cardiogenic Shock: Insights From the DOREMI Trial | Journal of the American Heart Association | 2022 | 59 |
| 50 | Antimicrobial Stewardship Programs in Long‐Term Care Settings: A Meta‐Analysis and Systematic Review | Journal of the American Geriatrics Society | 2019 | 56 |
