# | Title | Journal | Year | Citations |
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|
1 | Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition | Diabetes Research and Clinical Practice | 2019 | 6,413 |
2 | Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression | International Journal of Epidemiology | 2015 | 5,738 |
3 | World Health Organization 2020 guidelines on physical activity and sedentary behaviour | British Journal of Sports Medicine | 2020 | 4,796 |
4 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,992 |
5 | An atlas of genetic correlations across human diseases and traits | Nature Genetics | 2015 | 3,389 |
6 | Identification of the breast cancer susceptibility gene BRCA2 | Nature | 1995 | 3,267 |
7 | Genomic Classification and Prognosis in Acute Myeloid Leukemia | New England Journal of Medicine | 2016 | 3,246 |
8 | Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies | American Journal of Human Genetics | 2003 | 3,148 |
9 | Patterns of somatic mutation in human cancer genomes | Nature | 2007 | 2,844 |
10 | Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease | Nature Genetics | 2004 | 2,214 |
11 | Partitioning heritability by functional annotation using genome-wide association summary statistics | Nature Genetics | 2015 | 2,204 |
12 | Genome-wide association study identifies novel breast cancer susceptibility loci | Nature | 2007 | 2,179 |
13 | Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers | JAMA - Journal of the American Medical Association | 2017 | 2,039 |
14 | Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals | Nature Genetics | 2018 | 1,992 |
15 | Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women | Lancet, The | 2016 | 1,874 |
16 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,855 |
17 | School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review | The Lancet Child and Adolescent Health | 2020 | 1,526 |
18 | Interpretation of the evidence for the efficacy and safety of statin therapy | Lancet, The | 2016 | 1,456 |
19 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,421 |
20 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,389 |
21 | Genomic atlas of the human plasma proteome | Nature | 2018 | 1,369 |
22 | Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization | JAMA - Journal of the American Medical Association | 2021 | 1,343 |
23 | PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations | Bioinformatics | 2019 | 1,327 |
24 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,254 |
25 | Triglycerides and the Risk of Coronary Heart Disease | Circulation | 2007 | 1,245 |
26 | The evolutionary history of lethal metastatic prostate cancer | Nature | 2015 | 1,223 |
27 | Accelerometer Data Collection and Processing Criteria to Assess Physical Activity and Other Outcomes: A Systematic Review and Practical Considerations | Sports Medicine | 2017 | 1,209 |
28 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,182 |
29 | FinnGen provides genetic insights from a well-phenotyped isolated population | Nature | 2023 | 1,138 |
30 | PhenoScanner: a database of human genotype–phenotype associations | Bioinformatics | 2016 | 1,117 |
31 | The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease | Cell | 2016 | 1,095 |
32 | Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants | Epidemiology | 2017 | 1,021 |
33 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 1,019 |
34 | Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors | European Journal of Epidemiology | 2015 | 995 |
35 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 978 |
36 | The genetic architecture of type 2 diabetes | Nature | 2016 | 973 |
37 | Cancer Incidence in BRCA1 Mutation Carriers | Journal of the National Cancer Institute | 2002 | 956 |
38 | Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies | Lancet, The | 2018 | 915 |
39 | Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people | Lancet Diabetes and Endocrinology,the | 2015 | 884 |
40 | Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types | Nature Genetics | 2018 | 878 |
41 | PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene | Nature Genetics | 2007 | 868 |
42 | Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2020 | 865 |
43 | Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis | European Journal of Epidemiology | 2018 | 861 |
44 | Association of Hemoglobin A1c with Cardiovascular Disease and Mortality in Adults: The European Prospective Investigation into Cancer in Norfolk | Annals of Internal Medicine | 2004 | 860 |
45 | Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial | Lancet, The | 2016 | 827 |
46 | Guidelines for performing Mendelian randomization investigations | Wellcome Open Research | 2019 | 821 |
47 | Association Between Dietary Factors and Mortality From Heart Disease, Stroke, and Type 2 Diabetes in the United States | JAMA - Journal of the American Medical Association | 2017 | 818 |
48 | Sequence variant classification and reporting: recommendations for improving the interpretation of cancer susceptibility genetic test results | Human Mutation | 2008 | 800 |
49 | Multiple newly identified loci associated with prostate cancer susceptibility | Nature Genetics | 2008 | 798 |
50 | Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk | New England Journal of Medicine | 2015 | 784 |