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Top Articles

#TitleJournalYearCitations
1The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsNature20124,304
2Genetic studies of body mass index yield new insights for obesity biologyNature20153,280
3Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 StudiesAmerican Journal of Human Genetics20032,499
4Structure and function of matrix metalloproteinases and TIMPsCardiovascular Research20062,424
5Liquid biopsies come of age: towards implementation of circulating tumour DNANature Reviews Cancer20172,160
6Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexNature Genetics20102,141
7A DNA damage checkpoint response in telomere-initiated senescenceNature20032,027
8Analysis of Circulating Tumor DNA to Monitor Metastatic Breast CancerNew England Journal of Medicine20131,645
9ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage ResponseMolecular Cell20171,571
10Differential oestrogen receptor binding is associated with clinical outcome in breast cancerNature20121,567
11Genome-wide association study identifies novel breast cancer susceptibility lociNature20071,550
12The clonal and mutational evolution spectrum of primary triple-negative breast cancersNature20121,449
13Hundreds of variants clustered in genomic loci and biological pathways affect human heightNature20101,382
14Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamicsProceedings of the National Academy of Sciences of the United States of America20131,297
15Defining the role of common variation in the genomic and biological architecture of adult human heightNature Genetics20141,252
16Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancerNature Genetics20051,244
17Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trialLancet, The20101,241
18The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapesNature Communications20161,209
19Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-upAnnals of Oncology20221,201
20The landscape of cancer genes and mutational processes in breast cancerNature20121,195
21Cancer Susceptibility and the Functions of BRCA1 and BRCA2Cell20021,182
22Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripesScience20021,174
23A framework for oligonucleotide microarray preprocessing.Bioinformatics20101,152
24Association analysis identifies 65 new breast cancer risk lociNature20171,042
25The evolutionary history of lethal metastatic prostate cancerNature20151,007
26Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNAScience Translational Medicine2012944
27Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Nature Genetics2008867
28Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancerGut2013862
29Breast Cancer Risk Genes — Association Analysis in More than 113,000 WomenNew England Journal of Medicine2021857
30Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54Proceedings of the National Academy of Sciences of the United States of America2005852
31Population genomics of human gene expressionNature Genetics2007844
32Enhanced detection of circulating tumor DNA by fragment size analysisScience Translational Medicine2018821
33Large-scale genotyping identifies 41 new loci associated with breast cancer riskNature Genetics2013803
34Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer SubtypesAmerican Journal of Human Genetics2019760
35Challenges to curing primary brain tumoursNature Reviews Clinical Oncology2019716
36A comparison of background correction methods for two-colour microarrays.Bioinformatics2007710
37Molecular Classification and Molecular Forecasting of Breast Cancer: Ready for Clinical Application?Journal of Clinical Oncology2005662
38MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtypeGenome Biology2007658
39Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 StudiesPLoS Medicine2010645
40Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology SocietyEuropean Journal of Heart Failure2020638
41Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility lociNature Genetics2018631
42Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studiesCancer Epidemiology2016615
43Breast-Cancer Risk in Families with Mutations in PALB2New England Journal of Medicine2014610
44Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient dataLancet Oncology, The2014602
45Subclonal diversification of primary breast cancer revealed by multiregion sequencingNature Medicine2015602
46Multiple newly identified loci associated with prostate cancer susceptibilityNature Genetics2008599
47Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up☆Annals of Oncology2022599
48An open source chemical structure curation pipeline using RDKitJournal of Cheminformatics2020594
49Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotypeNature Reviews Cancer2009582
50Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary†Journal of Pathology2010580