| 1 | The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups | Nature | 2012 | 4,304 |
| 2 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,280 |
| 3 | Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies | American Journal of Human Genetics | 2003 | 2,499 |
| 4 | Structure and function of matrix metalloproteinases and TIMPs | Cardiovascular Research | 2006 | 2,424 |
| 5 | Liquid biopsies come of age: towards implementation of circulating tumour DNA | Nature Reviews Cancer | 2017 | 2,160 |
| 6 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,141 |
| 7 | A DNA damage checkpoint response in telomere-initiated senescence | Nature | 2003 | 2,027 |
| 8 | Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer | New England Journal of Medicine | 2013 | 1,645 |
| 9 | ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response | Molecular Cell | 2017 | 1,571 |
| 10 | Differential oestrogen receptor binding is associated with clinical outcome in breast cancer | Nature | 2012 | 1,567 |
| 11 | Genome-wide association study identifies novel breast cancer susceptibility loci | Nature | 2007 | 1,550 |
| 12 | The clonal and mutational evolution spectrum of primary triple-negative breast cancers | Nature | 2012 | 1,449 |
| 13 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,382 |
| 14 | Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 1,297 |
| 15 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,252 |
| 16 | Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer | Nature Genetics | 2005 | 1,244 |
| 17 | Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial | Lancet, The | 2010 | 1,241 |
| 18 | The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes | Nature Communications | 2016 | 1,209 |
| 19 | Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up | Annals of Oncology | 2022 | 1,201 |
| 20 | The landscape of cancer genes and mutational processes in breast cancer | Nature | 2012 | 1,195 |
| 21 | Cancer Susceptibility and the Functions of BRCA1 and BRCA2 | Cell | 2002 | 1,182 |
| 22 | Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes | Science | 2002 | 1,174 |
| 23 | A framework for oligonucleotide microarray preprocessing. | Bioinformatics | 2010 | 1,152 |
| 24 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,042 |
| 25 | The evolutionary history of lethal metastatic prostate cancer | Nature | 2015 | 1,007 |
| 26 | Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA | Science Translational Medicine | 2012 | 944 |
| 27 | Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 | Nature Genetics | 2008 | 867 |
| 28 | Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer | Gut | 2013 | 862 |
| 29 | Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women | New England Journal of Medicine | 2021 | 857 |
| 30 | Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 852 |
| 31 | Population genomics of human gene expression | Nature Genetics | 2007 | 844 |
| 32 | Enhanced detection of circulating tumor DNA by fragment size analysis | Science Translational Medicine | 2018 | 821 |
| 33 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 803 |
| 34 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 760 |
| 35 | Challenges to curing primary brain tumours | Nature Reviews Clinical Oncology | 2019 | 716 |
| 36 | A comparison of background correction methods for two-colour microarrays. | Bioinformatics | 2007 | 710 |
| 37 | Molecular Classification and Molecular Forecasting of Breast Cancer: Ready for Clinical Application? | Journal of Clinical Oncology | 2005 | 662 |
| 38 | MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype | Genome Biology | 2007 | 658 |
| 39 | Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies | PLoS Medicine | 2010 | 645 |
| 40 | Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society | European Journal of Heart Failure | 2020 | 638 |
| 41 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 631 |
| 42 | Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies | Cancer Epidemiology | 2016 | 615 |
| 43 | Breast-Cancer Risk in Families with Mutations in PALB2 | New England Journal of Medicine | 2014 | 610 |
| 44 | Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data | Lancet Oncology, The | 2014 | 602 |
| 45 | Subclonal diversification of primary breast cancer revealed by multiregion sequencing | Nature Medicine | 2015 | 602 |
| 46 | Multiple newly identified loci associated with prostate cancer susceptibility | Nature Genetics | 2008 | 599 |
| 47 | Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up☆ | Annals of Oncology | 2022 | 599 |
| 48 | An open source chemical structure curation pipeline using RDKit | Journal of Cheminformatics | 2020 | 594 |
| 49 | Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype | Nature Reviews Cancer | 2009 | 582 |
| 50 | Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary† | Journal of Pathology | 2010 | 580 |