| 1 | The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups | Nature | 2012 | 4,297 |
| 2 | Gastric cancer | Lancet, The | 2020 | 3,724 |
| 3 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,272 |
| 4 | Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies | American Journal of Human Genetics | 2003 | 2,508 |
| 5 | Structure and function of matrix metalloproteinases and TIMPs | Cardiovascular Research | 2006 | 2,416 |
| 6 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,146 |
| 7 | Liquid biopsies come of age: towards implementation of circulating tumour DNA | Nature Reviews Cancer | 2017 | 2,109 |
| 8 | A DNA damage checkpoint response in telomere-initiated senescence | Nature | 2003 | 2,010 |
| 9 | Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer | New England Journal of Medicine | 2013 | 1,630 |
| 10 | Differential oestrogen receptor binding is associated with clinical outcome in breast cancer | Nature | 2012 | 1,566 |
| 11 | Genome-wide association study identifies novel breast cancer susceptibility loci | Nature | 2007 | 1,549 |
| 12 | The clonal and mutational evolution spectrum of primary triple-negative breast cancers | Nature | 2012 | 1,446 |
| 13 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,388 |
| 14 | Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 1,289 |
| 15 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,252 |
| 16 | Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial | Lancet, The | 2010 | 1,240 |
| 17 | Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer | Nature Genetics | 2005 | 1,236 |
| 18 | The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes | Nature Communications | 2016 | 1,203 |
| 19 | The landscape of cancer genes and mutational processes in breast cancer | Nature | 2012 | 1,198 |
| 20 | Whole-Genome Shotgun Assembly and Analysis of the Genome of
Fugu rubripes | Science | 2002 | 1,184 |
| 21 | Cancer Susceptibility and the Functions of BRCA1 and BRCA2 | Cell | 2002 | 1,184 |
| 22 | A framework for oligonucleotide microarray preprocessing | Bioinformatics | 2010 | 1,157 |
| 23 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,044 |
| 24 | The evolutionary history of lethal metastatic prostate cancer | Nature | 2015 | 994 |
| 25 | Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA | Science Translational Medicine | 2012 | 934 |
| 26 | Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 | Nature Genetics | 2008 | 863 |
| 27 | Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer | Gut | 2013 | 855 |
| 28 | Population genomics of human gene expression | Nature Genetics | 2007 | 847 |
| 29 | Enhanced detection of circulating tumor DNA by fragment size analysis | Science Translational Medicine | 2018 | 813 |
| 30 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 803 |
| 31 | New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines | Chemical Reviews | 2020 | 769 |
| 32 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 748 |
| 33 | A comparison of background correction methods for two-colour microarrays | Bioinformatics | 2007 | 714 |
| 34 | Challenges to curing primary brain tumours | Nature Reviews Clinical Oncology | 2019 | 696 |
| 35 | Molecular Classification and Molecular Forecasting of Breast Cancer: Ready for Clinical Application? | Journal of Clinical Oncology | 2005 | 665 |
| 36 | Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans | Nature Machine Intelligence | 2021 | 665 |
| 37 | MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype | Genome Biology | 2007 | 661 |
| 38 | Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies | PLoS Medicine | 2010 | 641 |
| 39 | Baseline Cardiovascular Risk Assessment in Cancer Patients Scheduled to Receive Cardiotoxic Cancer Therapies: A Position Statement and New Risk Assessment Tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in Collaboration with the International Cardio-Oncology Society | European Journal of Heart Failure | 2020 | 629 |
| 40 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 628 |
| 41 | Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies | Cancer Epidemiology | 2016 | 600 |
| 42 | Subclonal diversification of primary breast cancer revealed by multiregion sequencing | Nature Medicine | 2015 | 599 |
| 43 | Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data | Lancet Oncology, The | 2014 | 598 |
| 44 | Multiple newly identified loci associated with prostate cancer susceptibility | Nature Genetics | 2008 | 595 |
| 45 | Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype | Nature Reviews Cancer | 2009 | 584 |
| 46 | Driver mutations in
TP53
are ubiquitous in high grade serous carcinoma of the ovary | Journal of Pathology | 2010 | 584 |
| 47 | Cancer therapy shapes the fitness landscape of clonal hematopoiesis | Nature Genetics | 2020 | 573 |
| 48 | Oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up | Annals of Oncology | 2022 | 572 |
| 49 | An open source chemical structure curation pipeline using RDKit | Journal of Cheminformatics | 2020 | 570 |
| 50 | Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients | Annals of Oncology | 2014 | 569 |
