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Top Articles

#TitleJournalYearCitations
1Chromatin Modifications and Their FunctionCell20079,419
2Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,789
3Regulation of chromatin by histone modificationsCell Research20114,648
4Cancer Epigenetics: From Mechanism to TherapyCell20122,609
5Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domainNature20012,581
6Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaNature20122,205
7DNA methylation-based classification of central nervous system tumoursNature20182,028
8Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2ANature19931,903
9Requirement of bic/microRNA-155 for Normal Immune FunctionScience20071,803
10The CBP co-activator is a histone acetyltransferaseNature19961,680
11Single-cell reconstruction of the early maternal–fetal interface in humansNature20181,665
12Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of GlioblastomaCancer Cell20121,600
13Relative Impact of Nucleotide and Copy Number Variation on Gene Expression PhenotypesScience20071,559
14Studies on ruminant saliva. 1. The composition and output of sheep's salivaBiochemical Journal19481,520
15Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamicsProceedings of the National Academy of Sciences of the United States of America20131,514
16Mutation in the tau gene in familial multiple system tauopathy with presenile dementiaProceedings of the National Academy of Sciences of the United States of America19981,495
17Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune diseaseImmunological Reviews20061,424
18The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid NeoplasmsLeukemia20221,398
19Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primerGenomics19921,365
20Scatter factor is a fibroblast-derived modulator of epithelial cell mobilityNature19871,303
21Retinoblastoma protein recruits histone deacetylase to repress transcriptionNature19981,190
22Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biologyBioinformatics20101,175
23Natural killer cells and pregnancyNature Reviews Immunology20021,099
24Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDSNature Genetics20021,097
25Acetylation: a regulatory modification to rival phosphorylation?EMBO Journal20001,050
26Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein exportNature20001,021
27Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive SuccessJournal of Experimental Medicine20041,002
28Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age GroupsCancer Cell2015974
29Gene map of the extended human MHCNature Reviews Genetics2004973
30Catalytic specificity of protein-tyrosine kinases is critical for selective signallingNature1995939
31Therapy with monoclonal antibodies by elimination of T-cell subsets in vivoNature1984906
32DNA methyltransferase Dnmt1 associates with histone deacetylase activityNature Genetics2000899
33Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomasActa Neuropathologica2012888
34Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation controlNature2017888
35Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and PathogenicityCell2021878
36The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone MethylationJournal of Biological Chemistry2003866
37SARS-CoV-2 evolution during treatment of chronic infectionNature2021858
38Clinical Features and Natural History of von Hippel-Lindau DiseaseQJM - Monthly Journal of the Association of Physicians1990841
39Histone methylation in transcriptional controlCurrent Opinion in Genetics and Development2002837
40Induction of Immunological Tolerance by Porcine Liver AllograftsNature1969825
41Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)European Journal of Immunology2019816
42The order HerpesviralesArchives of Virology2009810
43IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microgliaNature Immunology2012796
44Dissecting the genomic complexity underlying medulloblastomaNature2012781
45Appendix—Spectrum of horse-heart cytochrome cBiochemical Journal1959775
46Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activityJournal of Experimental Medicine2005775
47Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer SubtypesAmerican Journal of Human Genetics2019770
48Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescenceEMBO Journal2002768
49CD28 and CTLA‐4 coreceptor expression and signal transductionImmunological Reviews2009760
50Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription FactorScience2002759