The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings | Molecular Oncology | 2011 | 492 |
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization | Nature Medicine | 2011 | 486 |
Guidelines for the management of oesophageal and gastric cancer | Gut | 2011 | 404 |
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors | Molecular Cell | 2011 | 355 |
Use of the mouse aortic ring assay to study angiogenesis | Nature Protocols | 2011 | 333 |
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes | Chemistry and Biology | 2011 | 269 |
microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer | Cancer Research | 2011 | 253 |
The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis | British Journal of Cancer | 2011 | 217 |
Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate | Nucleic Acids Research | 2011 | 208 |
RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis | Seminars in Cell and Developmental Biology | 2011 | 196 |
Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer | PLoS ONE | 2011 | 175 |
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation | Radiotherapy and Oncology | 2011 | 144 |
Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers | Breast Cancer Research | 2011 | 124 |
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene | Human Molecular Genetics | 2011 | 105 |
A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours | British Journal of Cancer | 2011 | 99 |
UV stalled replication forks restart by re-priming in human fibroblasts | Nucleic Acids Research | 2011 | 97 |
Cavitation-enhanced extravasation for drug delivery | Ultrasound in Medicine and Biology | 2011 | 91 |
DNA double-strand break repair pathways, chromosomal rearrangements and cancer | Seminars in Cell and Developmental Biology | 2011 | 87 |
The angiogenic process as a therapeutic target in cancer | Biochemical Pharmacology | 2011 | 66 |
Gene expression and hypoxia in breast cancer | Genome Medicine | 2011 | 64 |
Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2011 | 63 |
Kinetics of reduction of tyrosine phenoxyl radicals by glutathione | Archives of Biochemistry and Biophysics | 2011 | 54 |
Reasons given by patients for participating, or not, in Phase 1 cancer trials | European Journal of Cancer | 2011 | 54 |
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma | PLoS ONE | 2011 | 53 |
ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair | EMBO Reports | 2011 | 48 |