| 1 | MEMOTE for standardized genome-scale metabolic model testing | Nature Biotechnology | 2020 | 468 |
| 2 | Hypergraphs and Cellular Networks | PLoS Computational Biology | 2009 | 376 |
| 3 | A Logical Model Provides Insights into T Cell Receptor Signaling | PLoS Computational Biology | 2007 | 330 |
| 4 | Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction | Molecular Systems Biology | 2009 | 324 |
| 5 | MaxSynBio: Avenues Towards Creating Cells from the Bottom Up | Angewandte Chemie - International Edition | 2018 | 294 |
| 6 | Bistability Analyses of a Caspase Activation Model for Receptor-induced Apoptosis | Journal of Biological Chemistry | 2004 | 269 |
| 7 | Overview of Surrogate Modeling in Chemical Process Engineering | Chemie-Ingenieur-Technik | 2019 | 262 |
| 8 | Comparative Performance of Four Methods for High-throughput Glycosylation Analysis of Immunoglobulin G in Genetic and Epidemiological Research | Molecular and Cellular Proteomics | 2014 | 190 |
| 9 | Computer‐aided design of ionic liquids as solvents for extractive desulfurization | AICHE Journal | 2018 | 184 |
| 10 | The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data | PLoS Computational Biology | 2009 | 171 |
| 11 | Navigating through metaproteomics data: A logbook of database searching | Proteomics | 2015 | 152 |
| 12 | Quantitative mapping of glycoprotein micro‐heterogeneity and macro‐heterogeneity: an evaluation of mass spectrometry signal strengths using synthetic peptides and glycopeptides | Journal of Mass Spectrometry | 2013 | 144 |
| 13 | Bioreactors for high cell density and continuous multi-stage cultivations: options for process intensification in cell culture-based viral vaccine production | Applied Microbiology and Biotechnology | 2016 | 131 |
| 14 | Temperature‐dependent dynamic control of the TCA cycle increases volumetric productivity of itaconic acid production by Escherichia coli | Biotechnology and Bioengineering | 2018 | 122 |
| 15 | Metaproteomics of complex microbial communities in biogas plants | Microbial Biotechnology | 2015 | 111 |
| 16 | Enumeration of Smallest Intervention Strategies in Genome-Scale Metabolic Networks | PLoS Computational Biology | 2014 | 107 |
| 17 | Metaproteome analysis reveals that syntrophy, competition, and phage-host interaction shape microbial communities in biogas plants | Microbiome | 2019 | 107 |
| 18 | CO2 methanation: Optimal start‐up control of a fixed‐bed reactor for power‐to‐gas applications | AICHE Journal | 2017 | 101 |
| 19 | Bioreactor concepts for cell culture-based viral vaccine production | Expert Review of Vaccines | 2015 | 98 |
| 20 | Machine learning for material characterization with an application for predicting mechanical properties | GAMM Mitteilungen | 2021 | 95 |
| 21 | A Robust and Universal Metaproteomics Workflow for Research Studies and Routine Diagnostics Within 24 h Using Phenol Extraction, FASP Digest, and the MetaProteomeAnalyzer | Frontiers in Microbiology | 2019 | 92 |
| 22 | Integrated solvent and process design exemplified for a Diels–Alder reaction | AICHE Journal | 2015 | 91 |
| 23 | Modeling the electron transport chain of purple non‐sulfur bacteria | Molecular Systems Biology | 2008 | 83 |
| 24 | Colonic metaproteomic signatures of active bacteria and the host in obesity | Proteomics | 2015 | 81 |
| 25 | Literally Green Chemical Synthesis of Artemisinin from Plant Extracts | Angewandte Chemie - International Edition | 2018 | 80 |
| 26 | Extending the UNIFAC model for ionic liquid–solute systems by combining experimental and computational databases | AICHE Journal | 2020 | 78 |
| 27 | Multiscale Modeling of Influenza A Virus Infection Supports the Development of Direct-Acting Antivirals | PLoS Computational Biology | 2013 | 74 |
| 28 | Site-specific O-Glycosylation Analysis of Human Blood Plasma Proteins | Molecular and Cellular Proteomics | 2016 | 74 |
| 29 | When Do Two‐Stage Processes Outperform One‐Stage Processes? | Biotechnology Journal | 2018 | 73 |
| 30 | Data‐driven model order reduction of quadratic‐bilinear systems | Numerical Linear Algebra With Applications | 2018 | 71 |
| 31 | From elementary flux modes to elementary flux vectors: Metabolic pathway analysis with arbitrary linear flux constraints | PLoS Computational Biology | 2017 | 69 |
| 32 | Rational design of double salt ionic liquids as extraction solvents: Separation of thiophene/n‐octane as example | AICHE Journal | 2019 | 66 |
| 33 | Minimal cut sets in a metabolic network are elementary modes in a dual network | Bioinformatics | 2012 | 64 |
| 34 | Toward Animal Cell Culture–Based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity | Journal of Immunology | 2013 | 64 |
| 35 | OptMDFpathway: Identification of metabolic pathways with maximal thermodynamic driving force and its application for analyzing the endogenous CO2 fixation potential of Escherichia coli | PLoS Computational Biology | 2018 | 62 |
| 36 | Enforced ATP futile cycling increases specific productivity and yield of anaerobic lactate production in Escherichia coli | Biotechnology and Bioengineering | 2015 | 60 |
| 37 | Neural recommender system for the activity coefficient prediction andUNIFACmodel extension of ionicliquid‐solutesystems | AICHE Journal | 2021 | 60 |
| 38 | Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG) | Molecular and Cellular Proteomics | 2016 | 58 |
| 39 | The Fine Art of Destruction: A Guide to In‐Depth Glycoproteomic Analyses—Exploiting the Diagnostic Potential of Fragment Ions | Proteomics | 2018 | 56 |
| 40 | Synthetic glycans control gut microbiome structure and mitigate colitis in mice | Nature Communications | 2022 | 55 |
| 41 | MALDI‐TOF‐MS analysis of sialylated glycans and glycopeptides using 4‐chloro‐α‐cyanocinnamic acid matrix | Proteomics | 2012 | 54 |
| 42 | A robust, cost‐effective method for DNA, RNA and protein co‐extraction from soil, other complex microbiomes and pure cultures | Molecular Ecology Resources | 2019 | 53 |
| 43 | Hydrogen Permeation in PEM Electrolyzer Cells Operated at Asymmetric Pressure Conditions | Journal of the Electrochemical Society | 2016 | 52 |
| 44 | Finite-Data Error Bounds for Koopman-Based Prediction and Control | Journal of Nonlinear Science | 2022 | 52 |
| 45 | The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium Channel | PLoS Computational Biology | 2016 | 50 |
| 46 | Quantitative Assessment of Sialo‐Glycoproteins and N‐Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells | ChemBioChem | 2017 | 49 |
| 47 | Model‐based Optimal Sabatier Reactor Design for Power‐to‐Gas Applications | Energy Technology | 2017 | 49 |
| 48 | Redox behavior and reduction mechanism of Fe2O3–CeZrO2 as oxygen storage material | Journal of Materials Science | 2007 | 48 |
| 49 | Metaproteome analysis of sewage sludge from membrane bioreactors | Proteomics | 2011 | 48 |
| 50 | Development of a high‐throughput glycoanalysis method for the characterization of oligosaccharides in human milk utilizing multiplexed capillary gel electrophoresis with laser‐induced fluorescence detection | Electrophoresis | 2013 | 48 |