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| 2 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases | Cell Research | 2008 | 4,335 |
| 3 | SOAP2: an improved ultrafast tool for short read alignment | Bioinformatics | 2009 | 3,531 |
| 4 | A Draft Sequence of the Rice Genome (
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L. ssp.
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| 5 | SOAP: short oligonucleotide alignment program | Bioinformatics | 2008 | 3,262 |
| 6 | De novo assembly of human genomes with massively parallel short read sequencing | Genome Research | 2010 | 2,669 |
| 7 | Independent optical excitation of distinct neural populations | Nature Methods | 2014 | 2,365 |
| 8 | Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement | Nature Biotechnology | 2013 | 1,193 |
| 9 | Comparison of Next-Generation Sequencing Systems | Journal of Biomedicine and Biotechnology | 2012 | 1,153 |
| 10 | A Draft Sequence for the Genome of the Domesticated Silkworm (
Bombyx mori
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| 11 | Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility | Nature Genetics | 2014 | 1,026 |
| 12 | Comparative genomics reveals insights into avian genome evolution and adaptation | Science | 2014 | 1,017 |
| 13 | Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma | Nature Genetics | 2012 | 878 |
| 14 | SNP detection for massively parallel whole-genome resequencing | Genome Research | 2009 | 876 |
| 15 | Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers | Nature Biotechnology | 2011 | 876 |
| 16 | The Genomes of Oryza sativa: A History of Duplications | PLoS Biology | 2005 | 861 |
| 17 | Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels | Nature Genetics | 2012 | 861 |
| 18 | The yak genome and adaptation to life at high altitude | Nature Genetics | 2012 | 859 |
| 19 | The diploid genome sequence of an Asian individual | Nature | 2008 | 846 |
| 20 | The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions | Nature Genetics | 2012 | 812 |
| 21 | Natural selection on
EPAS1
(
HIF2α
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| 22 | Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements | Water Research | 2017 | 792 |
| 23 | Whole-genome sequencing of cultivated and wild peppers provides insights into
Capsicum
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| 24 | All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins | Nature Methods | 2014 | 763 |
| 25 | Distinct DNA methylomes of newborns and centenarians | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 758 |
| 26 | Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma | Cancer Cell | 2011 | 679 |
| 27 | Integrated Profiling of MicroRNAs and mRNAs: MicroRNAs Located on Xq27.3 Associate with Clear Cell Renal Cell Carcinoma | PLoS ONE | 2010 | 654 |
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| 29 | Comprehensive phylogeny of ray-finned fishes (Actinopterygii) based on transcriptomic and genomic data | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 573 |
| 30 | The half-life of DNA in bone: measuring decay kinetics in 158 dated fossils | Proceedings of the Royal Society B: Biological Sciences | 2012 | 546 |
| 31 | Identification of natural compounds with antiviral activities against SARS-associated coronavirus | Antiviral Research | 2005 | 519 |
| 32 | A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution | Nature Genetics | 2016 | 515 |
| 33 | Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci | Nature Genetics | 2011 | 507 |
| 34 | Metagenomic species profiling using universal phylogenetic marker genes | Nature Methods | 2013 | 501 |
| 35 | TreeFam: a curated database of phylogenetic trees of animal gene families | Nucleic Acids Research | 2006 | 488 |
| 36 | Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism | Nature Genetics | 2015 | 485 |
| 37 | The
Symbiodinium kawagutii
genome illuminates dinoflagellate gene expression and coral symbiosis | Science | 2015 | 482 |
| 38 | Coding and noncoding landscape of extracellular RNA released by human glioma stem cells | Nature Communications | 2017 | 478 |
| 39 | A catalog of the mouse gut metagenome | Nature Biotechnology | 2015 | 475 |
| 40 | Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome | Genome Research | 2010 | 460 |
| 41 | A genome triplication associated with early diversification of the core eudicots | Genome Biology | 2012 | 453 |
| 42 | Alterations of the Gut Microbiome in Hypertension | Frontiers in Cellular and Infection Microbiology | 2017 | 439 |
| 43 | Exploring genetic variation in the tomato (Solanum section Lycopersicon) clade by whole‐genome sequencing | Plant Journal | 2014 | 422 |
| 44 | Historical variations in mutation rate in an epidemic pathogen,
Yersinia pestis | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 417 |
| 45 | A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms | Nature | 2004 | 409 |
| 46 | Streptococcal Toxic Shock Syndrome Caused by Streptococcus suis Serotype 2 | PLoS Medicine | 2006 | 380 |
| 47 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings | Cell Research | 2012 | 374 |
| 48 | Insight into the evolution of the Solanaceae from the parental genomes of Petunia hybrida | Nature Plants | 2016 | 361 |
| 49 | Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies | PLoS ONE | 2008 | 342 |
| 50 | Algal ancestor of land plants was preadapted for symbiosis | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 336 |
