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| 2 | Gene Therapy Using Adeno-Associated Virus Vectors | Clinical Microbiology Reviews | 2008 | 812 |
| 3 | Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers | Nature Genetics | 2015 | 687 |
| 4 | Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 540 |
| 5 | Pyrene‐Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids | Angewandte Chemie - International Edition | 2011 | 507 |
| 6 | Polygenic control of susceptibility to murine systemic lupus erythematosus | Immunity | 1994 | 486 |
| 7 | Aptamer/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins | Angewandte Chemie - International Edition | 2017 | 464 |
| 8 | High-throughput gene and SNP discovery in Eucalyptus grandis, an uncharacterized genome | BMC Genomics | 2008 | 431 |
| 9 | Obsessive-Compulsive Disorder | JAMA - Journal of the American Medical Association | 2017 | 420 |
| 10 | Accuracy of Genomic Selection Methods in a Standard Data Set of Loblolly Pine (Pinus taedaL.) | Genetics | 2012 | 409 |
| 11 | Cancer Risks Associated With GermlinePALB2Pathogenic Variants: An International Study of 524 Families | Journal of Clinical Oncology | 2020 | 376 |
| 12 | The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance | EMBO Molecular Medicine | 2013 | 371 |
| 13 | Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives | Angewandte Chemie - International Edition | 2021 | 362 |
| 14 | DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3B | Molecular and Cellular Biology | 2008 | 352 |
| 15 | Diversification of Rosaceae since the Late Cretaceous based on plastid phylogenomics | New Phytologist | 2017 | 351 |
| 16 | Light-switching excimer probes for rapid protein monitoring in complex biological fluids | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 342 |
| 17 | DNA aptamer–micelle as an efficient detection/delivery vehicle toward cancer cells | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 338 |
| 18 | Methylation changes atNR3C1in newborns associate with maternal prenatal stress exposure and newborn birth weight | Epigenetics | 2012 | 324 |
| 19 | Noncovalent Assembly of Carbon Nanotubes and Single-Stranded DNA: An Effective Sensing Platform for Probing Biomolecular Interactions | Analytical Chemistry | 2008 | 309 |
| 20 | Pyrene Excimer Signaling Molecular Beacons for Probing Nucleic Acids | Journal of the American Chemical Society | 2008 | 308 |
| 21 | In vitro selection with artificial expanded genetic information systems | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 308 |
| 22 | Speed congenics: a classic technique in the fast lane (relatively speaking) | Trends in Immunology | 1997 | 304 |
| 23 | Aluminum tolerance in maize is associated with higherMATE1gene copy number | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 293 |
| 24 | Plastid phylogenomic analysis of green plants: A billion years of evolutionary history | American Journal of Botany | 2018 | 279 |
| 25 | Splicing biomarkers of disease severity in myotonic dystrophy | Annals of Neurology | 2013 | 267 |
| 26 | Aptamer Directly Evolved from Live Cells Recognizes Membrane Bound Immunoglobin Heavy Mu Chain in Burkitt's Lymphoma Cells | Molecular and Cellular Proteomics | 2007 | 260 |
| 27 | Cortisol and DHEA in development and psychopathology | Hormones and Behavior | 2017 | 256 |
| 28 | Accelerating the domestication of trees using genomic selection: accuracy of prediction models across ages and environments | New Phytologist | 2012 | 247 |
| 29 | Dissecting Molecular Evolution in the Highly Diverse Plant Clade Caryophyllales Using Transcriptome Sequencing | Molecular Biology and Evolution | 2015 | 220 |
| 30 | Eucalyptus applied genomics: from gene sequences to breeding tools | New Phytologist | 2008 | 216 |
| 31 | Myosin IIb Regulates Actin Dynamics during Synaptic Plasticity and Memory Formation | Neuron | 2010 | 210 |
| 32 | LPS induces KH‐type splicing regulatory protein‐dependent processing of microRNA‐155 precursors in macrophages | FASEB Journal | 2009 | 197 |
| 33 | Pure polyploidy: Closing the gaps in autopolyploid research | Journal of Systematics and Evolution | 2017 | 188 |
| 34 | Compound loss of muscleblind‐like function in myotonic dystrophy | EMBO Molecular Medicine | 2013 | 185 |
| 35 | Gold‐Coated Fe3O4 Nanoroses with Five Unique Functions for Cancer Cell Targeting, Imaging, and Therapy | Advanced Functional Materials | 2014 | 185 |
| 36 | Molecular assembly for high-performance bivalent nucleic acid inhibitor | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 184 |
| 37 | Unraveling Additive from Nonadditive Effects Using Genomic Relationship Matrices | Genetics | 2014 | 178 |
| 38 | The evolutionary history of ferns inferred from 25 low‐copy nuclear genes | American Journal of Botany | 2015 | 178 |
| 39 | Deep learning versus parametric and ensemble methods for genomic prediction of complex phenotypes | Genetics Selection Evolution | 2020 | 178 |
| 40 | New prospects in the detection and comparative analysis of hybridization in the tree of life | American Journal of Botany | 2018 | 174 |
| 41 | High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype–Phenotype Correlation | Human Mutation | 2015 | 172 |
| 42 | Are polyploids really evolutionary dead‐ends (again)? A critical reappraisal of Mayroseet al. (2011) | New Phytologist | 2014 | 167 |
| 43 | Metabolic engineering of sugarcane to accumulate energy‐dense triacylglycerols in vegetative biomass | Plant Biotechnology Journal | 2016 | 167 |
| 44 | Molecular Breeding to Enhance Ethanol Production from Corn and Sorghum Stover | Crop Science | 2007 | 163 |
| 45 | Insights into the historical assembly of East Asian subtropical evergreen broadleaved forests revealed by the temporal history of the tea family | New Phytologist | 2017 | 161 |
| 46 | Epigenomic Profiling Reveals Novel and Frequent Targets of Aberrant DNA Methylation-Mediated Silencing in Malignant Glioma | Cancer Research | 2006 | 160 |
| 47 | Evolution of Animal and Plant Dicers: Early Parallel Duplications and Recurrent Adaptation of Antiviral RNA Binding in Plants | Molecular Biology and Evolution | 2013 | 160 |
| 48 | RNAi suppression of lignin biosynthesis in sugarcane reduces recalcitrance for biofuel production from lignocellulosic biomass | Plant Biotechnology Journal | 2012 | 159 |
| 49 | Recent developments in polymers derived from industrial lignin | Journal of Applied Polymer Science | 2015 | 158 |
| 50 | Patterns of abiotic niche shifts in allopolyploids relative to their progenitors | New Phytologist | 2016 | 156 |
