| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion | Nature | 2012 | 1,593 |
| 2 | COT drives resistance to RAF inhibition through MAP kinase pathway reactivation | Nature | 2010 | 1,338 |
| 3 | Chemotherapy Regimen Predicts Steatohepatitis and an Increase in 90-Day Mortality After Surgery for Hepatic Colorectal Metastases | Journal of Clinical Oncology | 2006 | 1,211 |
| 4 | Lumpectomy plus Tamoxifen with or without Irradiation in Women 70 Years of Age or Older with Early Breast Cancer | New England Journal of Medicine | 2004 | 978 |
| 5 | BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma | Clinical Cancer Research | 2013 | 851 |
| 6 | Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery: International standards guideline statement | Laryngoscope | 2011 | 814 |
| 7 | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death | | 2020 | 677 |
| 8 | Selective BRAFV600E Inhibition Enhances T-Cell Recognition of Melanoma without Affecting Lymphocyte Function | Cancer Research | 2010 | 669 |
| 9 | Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping | Oncologist | 2012 | 642 |
| 10 | Simplified Staging for Hepatocellular Carcinoma | Journal of Clinical Oncology | 2002 | 624 |
| 11 | Toward Minimal Residual Disease-Directed Therapy in Melanoma | Cell | 2018 | 552 |
| 12 | PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition | Cancer Discovery | 2012 | 523 |
| 13 | BRCAPRO Validation, Sensitivity of Genetic Testing of BRCA1/BRCA2, and Prevalence of Other Breast Cancer Susceptibility Genes | Journal of Clinical Oncology | 2002 | 484 |
| 14 | The Activation of MAPK in Melanoma Cells Resistant to BRAF Inhibition Promotes PD-L1 Expression That Is Reversible by MEK and PI3K Inhibition | Clinical Cancer Research | 2013 | 426 |
| 15 | A melanocyte lineage program confers resistance to MAP kinase pathway inhibition | Nature | 2013 | 407 |
| 16 | p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis | Cancer Cell | 2006 | 404 |
| 17 | Presurgical Chemotherapy Compared With Immediate Surgery and Adjuvant Chemotherapy for Nonmetastatic Osteosarcoma: Pediatric Oncology Group Study POG-8651 | Journal of Clinical Oncology | 2003 | 372 |
| 18 | Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq | Nature Communications | 2018 | 363 |
| 19 | BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice | Clinical Cancer Research | 2013 | 349 |
| 20 | Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1 | Nature | 2009 | 346 |
| 21 | Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma | Nature Medicine | 2012 | 338 |
| 22 | Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy | Cancer Discovery | 2016 | 336 |
| 23 | Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma | Hepatology | 2014 | 298 |
| 24 | Prognostic and Therapeutic Implications of Microvascular Invasion in Hepatocellular Carcinoma | Annals of Surgical Oncology | 2019 | 289 |
| 25 | The Effect of Surgery and Grade on Outcome of Gastrointestinal Stromal Tumors | Archives of Surgery | 2001 | 285 |
| 26 | Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism | PLoS ONE | 2014 | 285 |
| 27 | Treatment and Outcome of 82 Patients with Angiosarcoma | Annals of Surgical Oncology | 2007 | 280 |
| 28 | American Association of Clinical Endocrinologists and American College of Endocrinology Disease State Clinical Review: The Increasing Incidence of Thyroid Cancer | Endocrine Practice | 2015 | 271 |
| 29 | Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma | Cell Metabolism | 2019 | 271 |
| 30 | Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma | Clinical Cancer Research | 2012 | 268 |
| 31 | External branch of the superior laryngeal nerve monitoring during thyroid and parathyroid surgery: International Neural Monitoring Study Group standards guideline statement | Laryngoscope | 2013 | 266 |
| 32 | FOLFIRINOX in Locally Advanced Pancreatic Cancer: The Massachusetts General Hospital Cancer Center Experience | Oncologist | 2013 | 265 |
| 33 | Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas | PLoS Medicine | 2015 | 253 |
| 34 | Phase II Study of High-Dose Photon/Proton Radiotherapy in the Management of Spine Sarcomas | International Journal of Radiation Oncology Biology Physics | 2009 | 252 |
| 35 | Elucidating Distinct Roles for NF1 in Melanomagenesis | Cancer Discovery | 2013 | 219 |
| 36 | Long-term results of intraoperative electron beam radiotherapy for primary and recurrent retroperitoneal soft tissue sarcoma | International Journal of Radiation Oncology Biology Physics | 2001 | 218 |
| 37 | The importance of preoperative laryngoscopy in patients undergoing thyroidectomy: Voice, vocal cord function, and the preoperative detection of invasive thyroid malignancy | Surgery | 2006 | 218 |
| 38 | Protocol for the Examination of Specimens From Patients With Invasive Carcinoma of the Breast | Archives of Pathology and Laboratory Medicine | 2009 | 215 |
| 39 | The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: A comprehensive and evidence‐based comparison and review | Cancer | 2014 | 214 |
| 40 | The Impact of Radiation Therapy on the Risk of Lymphedema After Treatment for Breast Cancer: A Prospective Cohort Study | International Journal of Radiation Oncology Biology Physics | 2014 | 212 |
| 41 | Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver | BMC Cancer | 2014 | 208 |
| 42 | Consensus Guidelines on Genetic` Testing for Hereditary Breast Cancer from the American Society of Breast Surgeons | Annals of Surgical Oncology | 2019 | 203 |
| 43 | Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer | Clinical Cancer Research | 2021 | 200 |
| 44 | Outcome of patients with fibrolamellar hepatocellular carcinoma | Cancer | 2006 | 198 |
| 45 | HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response | Gastroenterology | 2019 | 197 |
| 46 | Detection of microscopic melanoma metastases in sentinel lymph nodes | Cancer | 1999 | 192 |
| 47 | Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas | Journal of Surgical Oncology | 2014 | 191 |
| 48 | Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy | Journal of the National Cancer Institute | 2016 | 191 |
| 49 | Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma | Journal of Hepatology | 2014 | 190 |
| 50 | The effect of surgery and radiotherapy on outcome of anaplastic thyroid carcinoma | Annals of Surgical Oncology | 2002 | 184 |
