| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Analysis of protein-coding genetic variation in 60,706 humans | Nature | 2016 | 9,271 |
| 2 | In vitro selection of RNA molecules that bind specific ligands | Nature | 1990 | 8,835 |
| 3 | PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes | Nature Genetics | 2003 | 8,581 |
| 4 | The Structure of Haplotype Blocks in the Human Genome | Science | 2002 | 5,355 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 6 | Biopython: freely available Python tools for computational molecular biology and bioinformatics | Bioinformatics | 2009 | 4,410 |
| 7 | The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans | Nature | 2000 | 4,365 |
| 8 | Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans | Cell | 1993 | 3,712 |
| 9 | Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation | Physiological Reviews | 2001 | 3,042 |
| 10 | PPAR-γ agonists inhibit production of monocyte inflammatory cytokines | Nature | 1998 | 2,847 |
| 11 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,676 |
| 12 | Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels | Science | 2007 | 2,645 |
| 13 | MAP kinase signalling cascade in Arabidopsis innate immunity | Nature | 2002 | 2,447 |
| 14 | Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA | Nature | 2000 | 2,193 |
| 15 | daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans | Science | 1997 | 2,095 |
| 16 | Isochorismate synthase is required to synthesize salicylic acid for plant defence | Nature | 2001 | 2,088 |
| 17 | SUGAR SENSING AND SIGNALING IN PLANTS: Conserved and Novel Mechanisms | Annual Review of Plant Biology | 2006 | 1,960 |
| 18 | Detecting recent positive selection in the human genome from haplotype structure | Nature | 2002 | 1,915 |
| 19 | The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans | Nature | 1997 | 1,833 |
| 20 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,804 |
| 21 | Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing | Cell | 2001 | 1,746 |
| 22 | Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease | Nature Genetics | 2011 | 1,724 |
| 23 | Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes | Nature Genetics | 2008 | 1,694 |
| 24 | Long Noncoding RNAs: Past, Present, and Future | Genetics | 2013 | 1,693 |
| 25 | Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action | Cell | 2002 | 1,636 |
| 26 | Synthesizing life | Nature | 2001 | 1,582 |
| 27 | Antibiotics for Emerging Pathogens | Science | 2009 | 1,579 |
| 28 | Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2 | Cell | 1993 | 1,568 |
| 29 | Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans | Nature | 2009 | 1,437 |
| 30 | Plants have a sensitive perception system for the most conserved domain of bacterial flagellin | Plant Journal | 1999 | 1,417 |
| 31 | Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 | Nature | 1993 | 1,414 |
| 32 | Cooperation between Complexes that Regulate Chromatin Structure and Transcription | Cell | 2002 | 1,375 |
| 33 | Engineered GFP as a vital reporter in plants | Current Biology | 1996 | 1,326 |
| 34 | Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 | Nature Biotechnology | 2013 | 1,324 |
| 35 | A central integrator of transcription networks in plant stress and energy signalling | Nature | 2007 | 1,308 |
| 36 | The microglial sensome revealed by direct RNA sequencing | Nature Neuroscience | 2013 | 1,305 |
| 37 | Genetic Mapping in Human Disease | Science | 2008 | 1,300 |
| 38 | Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans | Nature Genetics | 2008 | 1,295 |
| 39 | Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor | Science | 2003 | 1,284 |
| 40 | Common variants at 30 loci contribute to polygenic dyslipidemia | Nature Genetics | 2009 | 1,249 |
| 41 | Targeting virulence: a new paradigm for antimicrobial therapy | Nature Chemical Biology | 2007 | 1,195 |
| 42 | MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins | Nucleic Acids Research | 2016 | 1,195 |
| 43 | Mechanisms of Polycomb gene silencing: knowns and unknowns | Nature Reviews Molecular Cell Biology | 2009 | 1,193 |
| 44 | Epigenetic Regulation by Long Noncoding RNAs | Science | 2012 | 1,181 |
| 45 | A DNA Aptamer That Binds Adenosine and ATP | Biochemistry | 1995 | 1,170 |
| 46 | Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update | Physiological Reviews | 2012 | 1,157 |
| 47 | In vitro reconstitution of an abscisic acid signalling pathway | Nature | 2009 | 1,149 |
| 48 | The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction | Biochemistry | 1999 | 1,105 |
| 49 | Directed evolution of APEX2 for electron microscopy and proximity labeling | Nature Methods | 2015 | 1,085 |
| 50 | A simple phase-extraction assay for chloramphenicol acyltransferase activity | Gene | 1988 | 1,069 |
