| # | Title | Journal | Year | Citations |
|---|
|
| 1 | The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises | Pain | 2020 | 2,288 |
| 2 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,255 |
| 3 | Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council | Journal of Pain | 2016 | 2,157 |
| 4 | Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America | Clinical Infectious Diseases | 2016 | 2,150 |
| 5 | Improving long-term outcomes after discharge from intensive care unit | Critical Care Medicine | 2012 | 1,921 |
| 6 | The Epidemiology of Adult Obstructive Sleep Apnea | Proceedings of the American Thoracic Society | 2008 | 1,804 |
| 7 | A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 | Nature Genetics | 2005 | 1,584 |
| 8 | Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1 | Cell | 2011 | 1,350 |
| 9 | Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome | Nature Genetics | 2003 | 1,313 |
| 10 | The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material | Intensive Care Medicine | 2012 | 1,148 |
| 11 | International Guidelines for the Selection of Lung Transplant Candidates: 2006 Update—A Consensus Report From the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation | Journal of Heart and Lung Transplantation | 2006 | 1,086 |
| 12 | Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI | Nature Medicine | 2003 | 1,021 |
| 13 | Tricuspid Annular Displacement Predicts Survival in Pulmonary Hypertension | American Journal of Respiratory and Critical Care Medicine | 2006 | 962 |
| 14 | Sleep-Disordered Breathing, Glucose Intolerance, and Insulin Resistance: The Sleep Heart Health Study | American Journal of Epidemiology | 2004 | 937 |
| 15 | Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer | PLoS Medicine | 2006 | 912 |
| 16 | Cytoskeletal regulation of pulmonary vascular permeability | Journal of Applied Physiology | 2001 | 899 |
| 17 | Accuracy of Doppler Echocardiography in the Hemodynamic Assessment of Pulmonary Hypertension | American Journal of Respiratory and Critical Care Medicine | 2009 | 877 |
| 18 | Efficacy of Postoperative Epidural Analgesia | JAMA - Journal of the American Medical Association | 2003 | 867 |
| 19 | Sleep-disordered Breathing and Insulin Resistance in Middle-aged and Overweight Men | American Journal of Respiratory and Critical Care Medicine | 2002 | 853 |
| 20 | SEIPS 2.0: a human factors framework for studying and improving the work of healthcare professionals and patients | Ergonomics | 2013 | 843 |
| 21 | Multiple-laboratory comparison of microarray platforms | Nature Methods | 2005 | 816 |
| 22 | Right Heart Adaptation to Pulmonary Arterial Hypertension | Journal of the American College of Cardiology | 2013 | 789 |
| 23 | Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement | Journal of Clinical Investigation | 2001 | 785 |
| 24 | Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids | Science | 2000 | 772 |
| 25 | Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms | Nature | 2002 | 726 |
| 26 | Gender-Linked Brain Injury in Experimental Stroke | Stroke | 1998 | 703 |
| 27 | Outcome of delirium in critically ill patients: systematic review and meta-analysis | BMJ, The | 2015 | 701 |
| 28 | Diagnosis and Management of Obstructive Sleep Apnea | JAMA - Journal of the American Medical Association | 2020 | 701 |
| 29 | Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus | Cell | 2009 | 695 |
| 30 | Endothelial Dysfunction in Pulmonary Hypertension | Circulation | 2004 | 670 |
| 31 | Teamwork in healthcare: Key discoveries enabling safer, high-quality care. | American Psychologist | 2018 | 670 |
| 32 | Aging in COVID-19: Vulnerability, immunity and intervention | Ageing Research Reviews | 2021 | 663 |
| 33 | The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis | Nature Medicine | 2012 | 660 |
| 34 | The Control of Pain in Peripheral Tissue by Opioids | New England Journal of Medicine | 1995 | 657 |
| 35 | Does Continuous Peripheral Nerve Block Provide Superior Pain Control to Opioids? A Meta-Analysis | Anesthesia and Analgesia | 2006 | 646 |
| 36 | Perspective: Physician Leadership in Quality | Academic Medicine | 2009 | 646 |
| 37 | The IASP classification of chronic pain for ICD-11: chronic neuropathic pain | Pain | 2019 | 635 |
| 38 | In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1 | Biochemical and Biophysical Research Communications | 1996 | 632 |
| 39 | Inflammation, Growth Factors, and Pulmonary Vascular Remodeling | Journal of the American College of Cardiology | 2009 | 622 |
| 40 | Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome* | Critical Care Medicine | 2007 | 621 |
| 41 | Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2 | Journal of Immunology | 2006 | 617 |
| 42 | Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2019 | 612 |
| 43 | Organizational Characteristics of Intensive Care Units Related to Outcomes of Abdominal Aortic Surgery | JAMA - Journal of the American Medical Association | 1999 | 609 |
| 44 | Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation | Journal of Pediatrics | 2017 | 608 |
| 45 | Modulators of microglial activation and polarization after intracerebral haemorrhage | Nature Reviews Neurology | 2017 | 601 |
| 46 | Improving communication in the ICU using daily goals | Journal of Critical Care | 2003 | 599 |
| 47 | Inflammation after Intracerebral Hemorrhage | Journal of Cerebral Blood Flow and Metabolism | 2007 | 597 |
| 48 | Three-dimensional (3D) printed scaffold and material selection for bone repair | Acta Biomaterialia | 2019 | 596 |
| 49 | Hypoxic Pulmonary Vasoconstriction | Physiological Reviews | 2012 | 594 |
| 50 | Patient-Nurse Interrater Reliability and Agreement of the Richards-Campbell Sleep Questionnaire | American Journal of Critical Care | 2012 | 590 |
