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Top Articles

#TitleJournalYearCitations
1Stem cell ageing: does it happen and can we intervene?Expert Reviews in Molecular Medicine20071,506
2Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IVJournal of Human Hypertension20041,075
3Dendrimers in gene deliveryAdvanced Drug Delivery Reviews2005941
4The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligandsNucleic Acids Research2014832
5PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationBiochemical Journal2003730
6Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancerProceedings of the National Academy of Sciences of the United States of America2010551
7Behavioral Phenotypes of Disc1 Missense Mutations in MiceNeuron2007503
8mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleEMBO Journal2001441
9Association of Maternal Weight Gain in Pregnancy With Offspring Obesity and Metabolic and Vascular Traits in ChildhoodCirculation2010436
10Check your cultures! A list of cross‐contaminated or misidentified cell linesInternational Journal of Cancer2010419
11Underpinning compartmentalised cAMP signalling through targeted cAMP breakdownTrends in Biochemical Sciences2010401
12Contact guidance of CNS neurites on grooved quartz: influence of groove dimensions, neuronal age and cell typeJournal of Cell Science1997395
13Activation of two signal-transduction systems in hepatocytes by glucagonNature1986388
14Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1Nature Neuroscience2010376
15Human Atrial Action Potential and Ca 2+ ModelCirculation Research2011374
16Sleep deprivation impairs cAMP signalling in the hippocampusNature2009359
17 -Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates  -adrenoceptor switching from Gs to GiProceedings of the National Academy of Sciences of the United States of America2003358
18G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 ReceptorCirculation2005357
19Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized PhosphodiesterasesCirculation Research2004347
20The RACK1 Scaffold Protein: A Dynamic Cog in Cell Response MechanismsMolecular Pharmacology2002345
21The benzimidazole anthelmintic agents‐a reviewJournal of Veterinary Pharmacology and Therapeutics1990326
22The role of infiltrating immune cells in dysfunctional adipose tissueCardiovascular Research2017323
23Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteinsBiochemical Journal1988308
24The experimental power of FR900359 to study Gq-regulated biological processesNature Communications2015296
25cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular SystemCirculation Research2007285
26Disruption of the LOV−Jα Helix Interaction Activates Phototropin Kinase Activity†Biochemistry2004278
27Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approachPain2010276
28Regulating gene transcription in response to cyclic AMP elevationCellular Signalling2008272
29Human CRP Gene Polymorphism Influences CRP LevelsArteriosclerosis, Thrombosis, and Vascular Biology2003271
30The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579EMBO Journal1999270
31The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 IsoformJournal of Biological Chemistry1999269
32Compartmentalized Phosphodiesterase-2 Activity Blunts β-Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent PathwayCirculation Research2006254
33Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurementsNature Biotechnology2010250
34Avermectins and milbemycinsJournal of Veterinary Pharmacology and Therapeutics1996249
35Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological LandscapesPharmacological Reviews2010249
36Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetesNature1987248
37δ-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2Biochemical Journal1990248
38Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart FailurePharmacological Reviews2019245
39Downregulation of Multiple Stress Defense Mechanisms During Differentiation of Human Embryonic Stem CellsStem Cells2008242
40Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid ProductionCell Reports2020240
41Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm BirthJAMA - Journal of the American Medical Association2019238
42Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled ReceptorJournal of Biological Chemistry2000234
43Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmiasNature1981233
44Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy TransferJournal of Biological Chemistry2001230
45Complex Pharmacology of Free Fatty Acid ReceptorsChemical Reviews2017229
46Do antiepileptic drugs or generalized tonic–clonic seizure frequency increase SUDEP risk? A combined analysisEpilepsia2012228
47Genetic and Molecular Aspects of HypertensionCirculation Research2015228
48Treatment of Active Crohn’s Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral NutritionGastroenterology2019226
49Phase I and Pharmacodynamic Trial of the DNA Methyltransferase Inhibitor Decitabine and Carboplatin in Solid TumorsJournal of Clinical Oncology2007225
50The Pharmacology and Function of Receptors for Short-Chain Fatty AcidsMolecular Pharmacology2016221