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Top Articles

#TitleJournalYearCitations
153BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancersNature Structural and Molecular Biology2010939
2Glyconanoparticles allow pre-symptomatic in vivo imaging of brain diseaseProceedings of the National Academy of Sciences of the United States of America2009508
3miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP InhibitorsMolecular Cell2011425
4Motor Skill Learning Induces Changes in White Matter Microstructure and MyelinationJournal of Neuroscience2013410
5Regulation of autophagy by ATF4 in response to severe hypoxiaOncogene2010354
6The Vascular Basement Membrane as “Soil” in Brain MetastasisPLoS ONE2009291
7A method for estimating the oxygen consumption rate in multicellular tumour spheroidsJournal of the Royal Society Interface2014284
8PCNA on the crossroad of cancerBiochemical Society Transactions2009277
9Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?Radiation Research2013272
10RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesisSeminars in Cell and Developmental Biology2011262
11Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sitesNature Cell Biology2010237
12ATM Activation and Signaling under Hypoxic ConditionsMolecular and Cellular Biology2009222
13The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the ClinicClinical Oncology2014204
14Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through β1-Integrin SignalingCancer Research2011193
15Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic InstabilityCancer Research2010190
16Phase II Study of Conformal Hypofractionated Radiotherapy With Concurrent Gemcitabine in Muscle-Invasive Bladder CancerJournal of Clinical Oncology2011175
17Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vesselsNature Communications2012163
18Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phaseJournal of Cell Biology2010157
19BRCA2 acts as a RAD51 loader to facilitate telomere replication and cappingNature Structural and Molecular Biology2010149
20Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)PLoS ONE2011144
21PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNAJournal of Biological Chemistry2010140
22A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ KnockdownCancer Research2010139
23Molecular MRI enables early and sensitive detection of brain metastasesProceedings of the National Academy of Sciences of the United States of America2012139
24Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain LigandsJournal of Medicinal Chemistry2013131
25Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor VasculatureCancer Research2012128
26TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in MiceDevelopmental Cell2010126
27Tumor Vascular Changes Mediated by Inhibition of Oncogenic SignalingCancer Research2009124
28Coagulation and metastasis: what does the experimental literature tell us?British Journal of Haematology2013119
29Functional role of endothelial adhesion molecules in the early stages of brain metastasisNeuro-Oncology2014115
30Targeting the Nucleus: An Overview of Auger-Electron Radionuclide TherapyCurrent Drug Discovery Technologies2010113
31Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trialLancet Oncology, The2014112
32Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA ReplicationMolecular Cell2013110
33DNA double-strand break repair pathways, chromosomal rearrangements and cancerSeminars in Cell and Developmental Biology2011109
34Targeting Hypoxic Cells through the DNA Damage ResponseClinical Cancer Research2010102
35Neuroprotection by Dimethyloxalylglycine following Permanent and Transient Focal Cerebral Ischemia in RatsJournal of Cerebral Blood Flow and Metabolism201194
36A meta-analysis of CXCL12 expression for cancer prognosisBritish Journal of Cancer201794
37Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRSNMR in Biomedicine201193
38ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeresEMBO Journal201288
39Nanographene oxide-based radioimmunoconstructs for in vivo targeting and SPECT imaging of HER2-positive tumorsBiomaterials201387
40Proteomic Analyses Reveal High Expression of Decorin and Endoplasmin (HSP90B1) Are Associated with Breast Cancer Metastasis and Decreased SurvivalPLoS ONE201286
41Detector density and small field dosimetry: Integral versus point dose measurement schemesMedical Physics201382
42RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationJournal of Cell Biology200981
43Contextual regulation of pancreatic cancer stem cell phenotype and radioresistance by pancreatic stellate cellsRadiotherapy and Oncology201477
44Radiotherapy for Node Positive Penile Cancer: Experience of The Leeds Teaching HospitalsJournal of Urology201176
45Molecular Magnetic Resonance Imaging of Acute Vascular Cell Adhesion Molecule-1 Expression in a Mouse Model of Cerebral IschemiaJournal of Cerebral Blood Flow and Metabolism201073
46A Comparison of the Behavior of 64Cu-Acetate and 64Cu-ATSM In Vitro and In VivoJournal of Nuclear Medicine201471
47VCAM‐1‐targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosisFASEB Journal201170
48Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damageNucleic Acids Research201067
49The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesionsProceedings of the National Academy of Sciences of the United States of America201567
50Potent Fluoro‐oligosaccharide Probes of Adhesion in ToxoplasmosisChemBioChem200965