| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 2 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,872 |
| 3 | JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain | Cell | 1994 | 3,210 |
| 4 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 2,145 |
| 5 | Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells | Science | 2002 | 2,127 |
| 6 | Lack of Exercise Is a Major Cause of Chronic Diseases | | 2012 | 1,790 |
| 7 | Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology | Cell | 2020 | 1,268 |
| 8 | Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia | Annals of Neurology | 1994 | 1,063 |
| 9 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 981 |
| 10 | ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA | Brain | 1991 | 969 |
| 11 | New Biarsenical Ligands and Tetracysteine Motifs for Protein Labeling in Vitro and in Vivo: Synthesis and Biological Applications | Journal of the American Chemical Society | 2002 | 884 |
| 12 | p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes | Nature | 1994 | 869 |
| 13 | The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands | Nucleic Acids Research | 2014 | 832 |
| 14 | Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds | Cell | 2015 | 828 |
| 15 | TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway | Molecular and Cellular Biology | 2008 | 822 |
| 16 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 818 |
| 17 | Evidence for a mental health crisis in graduate education | Nature Biotechnology | 2018 | 766 |
| 18 | Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway | Nature Cell Biology | 2015 | 738 |
| 19 | ATP Signaling Is Crucial for Communication from Taste Buds to Gustatory Nerves | Science | 2005 | 714 |
| 20 | Apocynin Is Not an Inhibitor of Vascular NADPH Oxidases but an Antioxidant | Hypertension | 2008 | 681 |
| 21 | Endothelial dysfunction and vascular disease - a 30th anniversary update | Acta Physiologica | 2017 | 670 |
| 22 | Sphingosine 1-phosphate signalling in mammalian cells | Biochemical Journal | 2000 | 644 |
| 23 | NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential | Nature Reviews Drug Discovery | 2006 | 630 |
| 24 | A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes | Neurochemistry International | 2009 | 622 |
| 25 | Proteasomal function is impaired in substantia nigra in Parkinson's disease | Neuroscience Letters | 2001 | 609 |
| 26 | Ischemia/Reperfusion | Comprehensive Physiology | 2016 | 580 |
| 27 | Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity | Cell | 2021 | 562 |
| 28 | The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 554 |
| 29 | A gp130–Src–YAP module links inflammation to epithelial regeneration | Nature | 2015 | 543 |
| 30 | The future challenges facing the development of new antimicrobial drugs | Nature Reviews Drug Discovery | 2002 | 541 |
| 31 | TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8 + T cell exhaustion | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 529 |
| 32 | The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism | Cell Metabolism | 2012 | 520 |
| 33 | Meta-Analysis of Wine and Beer Consumption in Relation to Vascular Risk | Circulation | 2002 | 519 |
| 34 | Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities | CNS and Neurological Disorders - Drug Targets | 2013 | 507 |
| 35 | PSD-95 Assembles a Ternary Complex with theN-Methyl-d-aspartic Acid Receptor and a Bivalent Neuronal NO Synthase PDZ Domain | Journal of Biological Chemistry | 1999 | 505 |
| 36 | International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors | Pharmacological Reviews | 2010 | 499 |
| 37 | Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials | Lancet, The | 2009 | 496 |
| 38 | TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition | Journal of Biological Chemistry | 2009 | 490 |
| 39 | Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling | Nature Medicine | 2004 | 487 |
| 40 | Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS | EMBO Reports | 2011 | 483 |
| 41 | DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation | Annual Review of Pathology: Mechanisms of Disease | 2020 | 482 |
| 42 | Clusterin | International Journal of Biochemistry and Cell Biology | 2002 | 481 |
| 43 | Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental lewy body disease | Annals of Neurology | 1992 | 477 |
| 44 | Paracetamol: New Vistas of an Old Drug | CNS Neuroscience & Therapeutics | 2006 | 477 |
| 45 | Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice | Cell Metabolism | 2010 | 476 |
| 46 | Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex | Development (Cambridge) | 1996 | 475 |
| 47 | Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway | Cell | 1994 | 470 |
| 48 | Low-Level Laser Therapy in Acute Pain: A Systematic Review of Possible Mechanisms of Action and Clinical Effects in Randomized Placebo-Controlled Trials | Photomedicine and Laser Surgery | 2006 | 469 |
| 49 | Sphingosine 1-phosphate signalling in mammalian cells | Biochemical Journal | 2000 | 466 |
| 50 | Targeting cells with single vectors using multiple-feature Boolean logic | Nature Methods | 2014 | 465 |
