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Top Articles

#TitleJournalYearCitations
1The 2021 WHO Classification of Tumors of the Central Nervous System: a summaryNeuro-Oncology20216,209
2Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic ModalitiesCell20173,073
3DNA methylation-based classification of central nervous system tumoursNature20182,005
4The Human Cell AtlasELife01,396
5The landscape of genomic alterations across childhood cancersNature20181,074
6Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancersNature Medicine2020866
7A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposalModern Pathology2018791
8Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor OrganoidsCell2018734
9Mutational signature in colorectal cancer caused by genotoxic pks+ E. coliNature2020678
10Long‐term expanding human airway organoids for disease modelingEMBO Journal2019645
11Disease Modeling in Stem Cell-Derived 3D Organoid SystemsTrends in Molecular Medicine2017603
12WHO 2016 Classification of gliomasNeuropathology and Applied Neurobiology2018592
13Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D OrganoidsCell2018554
14An organoid platform for ovarian cancer captures intra- and interpatient heterogeneityNature Medicine2019532
15Interrogating open issues in cancer precision medicine with patient-derived xenograftsNature Reviews Cancer2017518
16A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic ScreeningCell Stem Cell2018498
17cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and gradingBrain Pathology2020394
18Longitudinal molecular trajectories of diffuse glioma in adultsNature2019350
19Neuroblastoma is composed of two super-enhancer-associated differentiation statesNature Genetics2017344
20Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid cultureNature Communications2019339
21Human Organoids: Tools for Understanding Biology and Treating DiseasesAnnual Review of Pathology: Mechanisms of Disease2020320
22Sarcoma classification by DNA methylation profilingNature Communications2021316
23EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumoursAnnals of Oncology2021315
24TERT rearrangements are frequent in neuroblastoma and identify aggressive tumorsNature Genetics2015309
25Tubuloids derived from human adult kidney and urine for personalized disease modelingNature Biotechnology2019301
26cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutantActa Neuropathologica2018294
27Xenograft and organoid model systems in cancer researchEMBO Journal2019285
28Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocolNature Reviews Urology2017281
29Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-upAnnals of Oncology2020270
30MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer ImmunotherapyCancers2020259
31Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysisNature Human Behaviour2020257
32Fasting-mimicking diet and hormone therapy induce breast cancer regressionNature2020243
33In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levelsNature Biotechnology2021243
34Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III StudyJournal of Clinical Oncology2021226
35Organoids in immunological researchNature Reviews Immunology2019224
36Glioma: experimental models and realityActa Neuropathologica2017214
37Differentiated human airway organoids to assess infectivity of emerging influenza virusProceedings of the National Academy of Sciences of the United States of America2018214
38Glioma progression is shaped by genetic evolution and microenvironment interactionsCell2022211
39Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized StudyJournal of Clinical Oncology2019209
40Human germ cell tumours from a developmental perspectiveNature Reviews Cancer2019203
41Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 studyLancet Oncology, The2021202
42An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneityNature Communications2020195
43Chemotherapy Side-Effects: Not All DNA Damage Is EqualCancers2022193
44Overview of the 2022 WHO Classification of Paragangliomas and PheochromocytomasEndocrine Pathology2022192
45The mutational landscape of human somatic and germline cellsNature2021185
46Retinoblastoma and Neuroblastoma Predisposition and SurveillanceClinical Cancer Research2017184
47Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trialLancet Oncology, The2019177
48Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoidsCell Stem Cell2021176
49Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivationHaematologica2016172
50Healthy play, better coping: The importance of play for the development of children in health and diseaseNeuroscience and Biobehavioral Reviews2018170