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Top Articles

#TitleJournalYearCitations
1Robust enumeration of cell subsets from tissue expression profilesNature Methods201511,708
2Dermatologist-level classification of skin cancer with deep neural networksNature201711,530
3The Immune Landscape of CancerImmunity20184,904
4Determining cell type abundance and expression from bulk tissues with digital cytometryNature Biotechnology20193,850
5The prognostic landscape of genes and infiltrating immune cells across human cancersNature Medicine20153,014
6Direct conversion of fibroblasts to functional neurons by defined factorsNature20102,921
7Association of reactive oxygen species levels and radioresistance in cancer stem cellsNature20092,407
8Epigenetic memory in induced pluripotent stem cellsNature20102,139
9Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinomaProceedings of the National Academy of Sciences of the United States of America20072,070
10Phenotypic characterization of human colorectal cancer stem cellsProceedings of the National Academy of Sciences of the United States of America20072,052
11An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverageNature Medicine20142,035
12PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunityNature20172,003
13CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem CellsCell20091,646
14Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem CellsNeuron20131,570
15The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumorsProceedings of the National Academy of Sciences of the United States of America20121,527
16A molecular cell atlas of the human lung from single-cell RNA sequencingNature20201,520
17Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in CultureScience20101,501
18CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid PhagocytosisCell20091,494
19Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian BrainScience20141,315
20Single-cell transcriptional diversity is a hallmark of developmental potentialScience20201,281
21An integral program for tissue renewal and regeneration: Wnt signaling and stem cell controlScience20141,250
22Induction of human neuronal cells by defined transcription factorsNature20111,238
23Cancer Stem Cells: Models and ConceptsAnnual Review of Medicine20071,217
24CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapyNature20191,203
25m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem CellsCell Stem Cell20141,184
26Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem CellsCell20091,165
27Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolutionNature Genetics20161,155
28A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse FibroblastsCell Stem Cell20101,097
29Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with ageNature20071,068
30Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin LymphomaCell20101,025
31Integrated digital error suppression for improved detection of circulating tumor DNANature Biotechnology20161,001
32Mechanisms of bone development and repairNature Reviews Molecular Cell Biology2020999
33Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA SequencingNeuron2019991
34The Biology of Cancer Stem CellsAnnual Review of Cell and Developmental Biology2007983
35Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem CellsCell Stem Cell2010930
36Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA ProfilingCancer Discovery2017918
37Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with ageProceedings of the National Academy of Sciences of the United States of America2011905
38Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell CarcinomaCell2020889
39Stem Cells and Cancer: Two Faces of EveCell2006879
40Stems Cells and the Pathways to Aging and CancerCell2008857
41CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cellsNature2016842
42Phagocytosis checkpoints as new targets for cancer immunotherapyNature Reviews Cancer2019828
43Neuronal Activity Promotes Glioma Growth through Neuroligin-3 SecretionCell2015817
44Undulating changes in human plasma proteome profiles across the lifespanNature Medicine2019801
45Reprogramming human T cell function and specificity with non-viral genome targetingNature2018794
46Hematopoietic stem cell: self‐renewal versus differentiationWiley Interdisciplinary Reviews: Systems Biology and Medicine2010788
47Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular DiseaseCell Stem Cell2012757
48Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stageNature Biotechnology2010756
49Quantitative assessment of single-cell RNA-sequencing methodsNature Methods2013726
50Nuclear reprogramming to a pluripotent state by three approachesNature2010725