| 1 | The CRISPR/Cas9 system for plant genome editing and beyond | Biotechnology Advances | 2015 | 1,107 |
| 2 | The production of recombinant pharmaceutical proteins in plants | Nature Reviews Genetics | 2003 | 868 |
| 3 | TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells | Life Science Alliance | 2020 | 738 |
| 4 | Molecular farming in plants: host systems and expression technology | Trends in Biotechnology | 2003 | 655 |
| 5 | Nrf2, the Master Regulator of Anti-Oxidative Responses | International Journal of Molecular Sciences | 2017 | 639 |
| 6 | Plant-based production of biopharmaceuticals | Current Opinion in Plant Biology | 2004 | 589 |
| 7 | Ecotoxic Effect of Photocatalytic Active Nanoparticles (TiO2) on Algae and Daphnids (8 pp) | Environmental Science and Pollution Research | 2006 | 563 |
| 8 | Plant cell cultures for the production of recombinant proteins | Nature Biotechnology | 2004 | 542 |
| 9 | Pesticide soil sorption parameters: theory, measurement, uses, limitations and reliability | Pest Management Science | 2002 | 479 |
| 10 | Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis | Redox Biology | 2020 | 339 |
| 11 | Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project | Ecotoxicology and Environmental Safety | 2003 | 323 |
| 12 | Sowing the seeds of success: pharmaceutical proteins from plants | Current Opinion in Biotechnology | 2005 | 323 |
| 13 | Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases | Biotechnology Advances | 2017 | 322 |
| 14 | Molecular farming for new drugs and vaccines | EMBO Reports | 2005 | 297 |
| 15 | Endosperm-Specific Co-Expression of Recombinant Soybean Ferritin and Aspergillus Phytase in Maize Results in Significant Increases in the Levels of Bioavailable Iron | Plant Molecular Biology | 2005 | 261 |
| 16 | Nutritional immunology: Diversification and diet-dependent expression of antimicrobial peptides in the black soldier fly Hermetia illucens | Developmental and Comparative Immunology | 2018 | 254 |
| 17 | Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro | Toxicology in Vitro | 2019 | 246 |
| 18 | Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins | Frontiers in Plant Science | 2019 | 222 |
| 19 | GMP issues for recombinant plant-derived pharmaceutical proteins | Biotechnology Advances | 2012 | 220 |
| 20 | Case study: bioavailability of tin and tin compounds | Ecotoxicology and Environmental Safety | 2003 | 213 |
| 21 | Making sense of big data in health research: Towards an EU action plan | Genome Medicine | 2016 | 211 |
| 22 | Progress in plant metabolic engineering | Current Opinion in Biotechnology | 2004 | 210 |
| 23 | The early research and development of ebselen | Biochemical Pharmacology | 2013 | 210 |
| 24 | Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy | Nature Communications | 2019 | 203 |
| 25 | Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials | Cancers | 2019 | 190 |
| 26 | Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE2and Cytokines | Mediators of Inflammation | 2017 | 187 |
| 27 | Taraxacum officinale and related species—An ethnopharmacological review and its potential as a commercial medicinal plant | Journal of Ethnopharmacology | 2015 | 186 |
| 28 | Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays | Journal of Clinical Virology | 2020 | 185 |
| 29 | Plants as sources of natural and recombinant anti-cancer agents | Biotechnology Advances | 2018 | 184 |
| 30 | Challenges and advances in the heterologous expression of cellulolytic enzymes: a review | Biotechnology for Biofuels | 2014 | 177 |
| 31 | Human biomonitoring of per- and polyfluoroalkyl substances in German blood plasma samples from 1982 to 2019 | Environment International | 2020 | 175 |
| 32 | Adapting OECD Aquatic Toxicity Tests for Use with Manufactured Nanomaterials: Key Issues and Consensus Recommendations | Environmental Science & Technology | 2015 | 174 |
| 33 | Improving target assessment in biomedical research: the GOT-IT recommendations | Nature Reviews Drug Discovery | 2020 | 174 |
| 34 | Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta | Insect Biochemistry and Molecular Biology | 2016 | 173 |
| 35 | THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro | Molecular Immunology | 2017 | 170 |
| 36 | Patterns of CRISPR/Cas9 activity in plants, animals and microbes | Plant Biotechnology Journal | 2016 | 168 |
| 37 | Ceramides as Novel Disease Biomarkers | Trends in Molecular Medicine | 2019 | 168 |
| 38 | Plant Molecular Pharming for the Treatment of Chronic and Infectious Diseases | Annual Review of Plant Biology | 2014 | 167 |
| 39 | Machine learning in pain research | Pain | 2018 | 165 |
| 40 | Very-large-scale production of antibodies in plants: The biologization of manufacturing | Biotechnology Advances | 2017 | 154 |
| 41 | Molecular farming – The slope of enlightenment | Biotechnology Advances | 2020 | 153 |
| 42 | Extraction and downstream processing of plant-derived recombinant proteins | Biotechnology Advances | 2015 | 149 |
| 43 | Silencing the expression of the salivary sheath protein causes transgenerational feeding suppression in the aphid Sitobion avenae | Plant Biotechnology Journal | 2015 | 148 |
| 44 | Characteristics of Genome Editing Mutations in Cereal Crops | Trends in Plant Science | 2017 | 145 |
| 45 | Scrapie Agent (Strain 263K) Can Transmit Disease via the Oral Route after Persistence in Soil over Years | PLoS ONE | 2007 | 143 |
| 46 | The digestive and defensive basis of carcass utilization by the burying beetle and its microbiota | Nature Communications | 2017 | 141 |
| 47 | Plant Molecular Farming – Integration and Exploitation of Side Streams to Achieve Sustainable Biomanufacturing | Frontiers in Plant Science | 2019 | 140 |
| 48 | Biotransformation Changes Bioaccumulation and Toxicity of Diclofenac in Aquatic Organisms | Environmental Science & Technology | 2020 | 138 |
| 49 | Nanomaterials: certain aspects of application, risk assessment and risk communication | Archives of Toxicology | 2017 | 136 |
| 50 | Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes. | Journal of Immunology | 1994 | 136 |