Tracking cancer drugs in living cells by thermal profiling of the proteome | Science | 2014 | 526 |
Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 282 |
Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes | EMBO Journal | 1998 | 147 |
Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1 | Journal of Biological Chemistry | 2009 | 146 |
Adsorption of surfactant lipids by single-walled carbon nanotubes in mouse lung upon pharyngeal aspiration | ACS Nano | 2012 | 145 |
Current developments in Coot for macromolecular model building of Electron Cryo-microscopy and Crystallographic Data | Protein Science | 2020 | 130 |
The enzymes of oxalate metabolism: unexpected structures and mechanisms | Archives of Biochemistry and Biophysics | 2005 | 125 |
Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 111 |
Intrinsic conformational energetics associated with the glycosyl torsion in DNA: a quantum mechanical study | Biophysical Journal | 2002 | 98 |
The X-ray crystal structure of beta-ketoacyl [acyl carrier protein] synthase I | FEBS Letters | 1999 | 93 |
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil | EMBO Journal | 2001 | 91 |
Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5'-phosphate-dependent enzymes | Journal of Molecular Biology | 1999 | 89 |
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution | Journal of Molecular Biology | 1998 | 80 |
Crystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family | Structure | 1996 | 78 |
Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition | Journal of Biological Chemistry | 2007 | 72 |
Crystal structure of decameric fructose-6-phosphate aldolase from Escherichia coli reveals inter-subunit helix swapping as a structural basis for assembly differences in the transaldolase family | Journal of Molecular Biology | 2002 | 67 |
Identification of catalytically important residues in yeast transketolase | Biochemistry | 1997 | 65 |
Ab initio conformational analysis of nucleic acid components: intrinsic energetic contributions to nucleic acid structure and dynamics | Biopolymers | 2001 | 65 |
Crystal structure of the carbohydrate recognition domain of p58/ERGIC-53, a protein involved in glycoprotein export from the endoplasmic reticulum | Journal of Biological Chemistry | 2002 | 63 |
Crystal structure of the reduced Schiff-base intermediate complex of transaldolase B from Escherichia coli: mechanistic implications for class I aldolases | Protein Science | 1997 | 60 |
Potential of mean force calculations of the stacking-unstacking process in single-stranded deoxyribodinucleoside monophosphates | Biophysical Journal | 1995 | 57 |
Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 54 |
Crystal structure analysis of a pentameric fungal and an icosahedral plant lumazine synthase reveals the structural basis for differences in assembly | Protein Science | 1999 | 53 |
Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid | FEBS Journal | 2003 | 52 |
Remote control of regioselectivity in acyl-acyl carrier protein-desaturases | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 51 |