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Top Articles

#TitleJournalYearCitations
1CHARMM: The biomolecular simulation programJournal of Computational Chemistry20097,384
2Cloning of a novel receptor expressed in rat prostate and ovary.Proceedings of the National Academy of Sciences of the United States of America19964,385
3Host–microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseNature20124,158
4Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and βEndocrinology19974,039
5Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor βEndocrinology19983,781
6RNA velocity of single cellsNature20182,913
7Premature ageing in mice expressing defective mitochondrial DNA polymeraseNature20042,378
8An atlas of active enhancers across human cell types and tissuesNature20142,342
9Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility lociNature Genetics20102,320
10Physical fitness in childhood and adolescence: a powerful marker of healthInternational Journal of Obesity20081,905
11The gut microbiota influences blood-brain barrier permeability in miceScience Translational Medicine20141,710
12Mechanisms of Estrogen ActionPhysiological Reviews20011,695
13Generation and reproductive phenotypes of mice lacking estrogen receptor βProceedings of the National Academy of Sciences of the United States of America19981,548
14Estrogen Receptors: How Do They Signal and What Are Their TargetsPhysiological Reviews20071,520
15The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validityPublic Health Nutrition20061,413
16Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors   and  Endocrinology19971,410
17The Norway spruce genome sequence and conifer genome evolutionNature20131,339
18Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon NanotubesChemical Research in Toxicology20081,262
19Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 DiabetesCell Metabolism20161,245
20Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47Nature Genetics20111,224
21Accelerometer Data Collection and Processing Criteria to Assess Physical Activity and Other Outcomes: A Systematic Review and Practical ConsiderationsSports Medicine20171,209
22Analysis of shared heritability in common disorders of the brainScience20181,165
23DNA-Binding Specificities of Human Transcription FactorsCell20131,123
24Sex-specific, male-line transgenerational responses in humansEuropean Journal of Human Genetics20061,084
25Quantitative single-cell RNA-seq with unique molecular identifiersNature Methods20141,074
26Principles for modulation of the nuclear receptor superfamilyNature Reviews Drug Discovery20041,034
27Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndromeProceedings of the National Academy of Sciences of the United States of America20041,001
28An atlas of human long non-coding RNAs with accurate 5′ endsNature2017930
29Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritisNature Biotechnology2013894
30Counting absolute numbers of molecules using unique molecular identifiersNature Methods2012893
31Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease SusceptibilityPLoS ONE2012884
32Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunityNature Genetics2012881
33Dynamics of the human gut microbiome in inflammatory bowel diseaseNature Microbiology2017878
34Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout MouseEndocrinology1997864
35Lgr5 marks cycling, yet long-lived, hair follicle stem cellsNature Genetics2008862
36Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonistEMBO Journal1999843
37Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer sizeToxicology Letters2009839
38Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.Proceedings of the National Academy of Sciences of the United States of America1992805
39Autophagy in major human diseasesEMBO Journal2021760
40Mitochondrial transcription factor A regulates mtDNA copy number in mammalsHuman Molecular Genetics2004748
41DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysisAmerican Journal of Human Genetics2016741
42Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonistsProceedings of the National Academy of Sciences of the United States of America2007733
43The role of the human homologue of Drosophila patched in sporadic basal cell carcinomasNature Genetics1996716
44Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel diseaseNature Genetics2011713
45Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature agingProceedings of the National Academy of Sciences of the United States of America2006694
46Role of Physical Activity and Sedentary Behavior in the Mental Health of Preschoolers, Children and Adolescents: A Systematic Review and Meta-AnalysisSports Medicine2019689
47The International Prevalence Study on Physical Activity: results from 20 countriesInternational Journal of Behavioral Nutrition and Physical Activity2009669
48Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared lociNature Genetics2016648
49Association between muscular strength and mortality in men: prospective cohort studyBMJ: British Medical Journal2008633
50Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosusNature Genetics2007612