# | Title | Journal | Year | Citations |
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|
1 | CHARMM: The biomolecular simulation program | Journal of Computational Chemistry | 2009 | 7,384 |
2 | Cloning of a novel receptor expressed in rat prostate and ovary. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 4,385 |
3 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,158 |
4 | Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β | Endocrinology | 1997 | 4,039 |
5 | Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β | Endocrinology | 1998 | 3,781 |
6 | RNA velocity of single cells | Nature | 2018 | 2,913 |
7 | Premature ageing in mice expressing defective mitochondrial DNA polymerase | Nature | 2004 | 2,378 |
8 | An atlas of active enhancers across human cell types and tissues | Nature | 2014 | 2,342 |
9 | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci | Nature Genetics | 2010 | 2,320 |
10 | Physical fitness in childhood and adolescence: a powerful marker of health | International Journal of Obesity | 2008 | 1,905 |
11 | The gut microbiota influences blood-brain barrier permeability in mice | Science Translational Medicine | 2014 | 1,710 |
12 | Mechanisms of Estrogen Action | Physiological Reviews | 2001 | 1,695 |
13 | Generation and reproductive phenotypes of mice lacking estrogen receptor β | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 1,548 |
14 | Estrogen Receptors: How Do They Signal and What Are Their Targets | Physiological Reviews | 2007 | 1,520 |
15 | The International Physical Activity Questionnaire (IPAQ): a study of concurrent and construct validity | Public Health Nutrition | 2006 | 1,413 |
16 | Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors and | Endocrinology | 1997 | 1,410 |
17 | The Norway spruce genome sequence and conifer genome evolution | Nature | 2013 | 1,339 |
18 | Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes | Chemical Research in Toxicology | 2008 | 1,262 |
19 | Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes | Cell Metabolism | 2016 | 1,245 |
20 | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 | Nature Genetics | 2011 | 1,224 |
21 | Accelerometer Data Collection and Processing Criteria to Assess Physical Activity and Other Outcomes: A Systematic Review and Practical Considerations | Sports Medicine | 2017 | 1,209 |
22 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,165 |
23 | DNA-Binding Specificities of Human Transcription Factors | Cell | 2013 | 1,123 |
24 | Sex-specific, male-line transgenerational responses in humans | European Journal of Human Genetics | 2006 | 1,084 |
25 | Quantitative single-cell RNA-seq with unique molecular identifiers | Nature Methods | 2014 | 1,074 |
26 | Principles for modulation of the nuclear receptor superfamily | Nature Reviews Drug Discovery | 2004 | 1,034 |
27 | Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 1,001 |
28 | An atlas of human long non-coding RNAs with accurate 5′ ends | Nature | 2017 | 930 |
29 | Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis | Nature Biotechnology | 2013 | 894 |
30 | Counting absolute numbers of molecules using unique molecular identifiers | Nature Methods | 2012 | 893 |
31 | Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility | PLoS ONE | 2012 | 884 |
32 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 881 |
33 | Dynamics of the human gut microbiome in inflammatory bowel disease | Nature Microbiology | 2017 | 878 |
34 | Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse | Endocrinology | 1997 | 864 |
35 | Lgr5 marks cycling, yet long-lived, hair follicle stem cells | Nature Genetics | 2008 | 862 |
36 | Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist | EMBO Journal | 1999 | 843 |
37 | Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size | Toxicology Letters | 2009 | 839 |
38 | Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 805 |
39 | Autophagy in major human diseases | EMBO Journal | 2021 | 760 |
40 | Mitochondrial transcription factor A regulates mtDNA copy number in mammals | Human Molecular Genetics | 2004 | 748 |
41 | DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis | American Journal of Human Genetics | 2016 | 741 |
42 | Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 733 |
43 | The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas | Nature Genetics | 1996 | 716 |
44 | Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease | Nature Genetics | 2011 | 713 |
45 | Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 694 |
46 | Role of Physical Activity and Sedentary Behavior in the Mental Health of Preschoolers, Children and Adolescents: A Systematic Review and Meta-Analysis | Sports Medicine | 2019 | 689 |
47 | The International Prevalence Study on Physical Activity: results from 20 countries | International Journal of Behavioral Nutrition and Physical Activity | 2009 | 669 |
48 | Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci | Nature Genetics | 2016 | 648 |
49 | Association between muscular strength and mortality in men: prospective cohort study | BMJ: British Medical Journal | 2008 | 633 |
50 | Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus | Nature Genetics | 2007 | 612 |