Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 2.8K |
Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy | Nature Biotechnology | 2012 | 446 |
Atomic view of a toxic amyloid small oligomer | Science | 2012 | 440 |
Α-synuclein misfolding and Parkinson's disease | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2012 | 406 |
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study | Journal of Neuroinflammation | 2012 | 307 |
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β | Nature | 2012 | 305 |
Functionalized cyclopropenes as bioorthogonal chemical reporters | Journal of the American Chemical Society | 2012 | 258 |
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo | Journal of Neuroscience | 2012 | 230 |
Radical SAM-dependent carbon insertion into the nitrogenase M-cluster | Science | 2012 | 212 |
Single-molecule lysozyme dynamics monitored by an electronic circuit | Science | 2012 | 182 |
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances | Biochemical Journal | 2012 | 168 |
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells | Journal of Immunology | 2012 | 158 |
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 149 |
Akt and mTOR in B Cell Activation and Differentiation | Frontiers in Immunology | 2012 | 127 |
Cowchock syndrome is associated with a mutation in apoptosis-inducing factor | American Journal of Human Genetics | 2012 | 101 |
Molecular determinants of scouting behavior in honey bees | Science | 2012 | 100 |
Vanadium nitrogenase: a two-hit wonder? | Dalton Transactions | 2012 | 96 |
Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection | PLoS ONE | 2012 | 96 |
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment | Blood | 2012 | 95 |
Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia | Journal of Neuroscience | 2012 | 94 |
Structural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligand | Journal of Biological Chemistry | 2012 | 93 |
Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 93 |
Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections | Journal of Virology | 2012 | 91 |
Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella | PLoS Biology | 2012 | 90 |
Before and after endosomal escape: roles of stimuli-converting siRNA/polymer interactions in determining gene silencing efficiency | Accounts of Chemical Research | 2012 | 88 |