| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Crystal structure of the β2 adrenergic receptor–Gs protein complex | Nature | 2011 | 2,783 |
| 2 | Glial and neuronal control of brain blood flow | Nature | 2010 | 2,068 |
| 3 | Trends in GPCR drug discovery: new agents, targets and indications | Nature Reviews Drug Discovery | 2017 | 1,922 |
| 4 | Structure of a nanobody-stabilized active state of the β2 adrenoceptor | Nature | 2011 | 1,542 |
| 5 | Capillary pericytes regulate cerebral blood flow in health and disease | Nature | 2014 | 1,534 |
| 6 | Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants | Molecular Microbiology | 2003 | 912 |
| 7 | FXR is a molecular target for the effects of vertical sleeve gastrectomy | Nature | 2014 | 828 |
| 8 | Cancer risk and oxidative DNA damage in man | Journal of Molecular Medicine | 1996 | 822 |
| 9 | Conformational biosensors reveal GPCR signalling from endosomes | Nature | 2013 | 741 |
| 10 | Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise | Experimental Physiology | 2009 | 731 |
| 11 | SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation | Pharmacological Reviews | 2011 | 730 |
| 12 | Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury | Journal of Cerebral Blood Flow and Metabolism | 2011 | 672 |
| 13 | Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index | Carcinogenesis | 1992 | 619 |
| 14 | Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase | Diabetologia | 2009 | 558 |
| 15 | GPCRdb: an information system for G protein-coupled receptors | Nucleic Acids Research | 2016 | 494 |
| 16 | Pharmacogenomics of GPCR Drug Targets | Cell | 2018 | 490 |
| 17 | Glial cells in (patho)physiology | Journal of Neurochemistry | 2012 | 467 |
| 18 | Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study | Lancet, The | 2014 | 461 |
| 19 | High Constitutive Signaling of the Ghrelin Receptor—Identification of a Potent Inverse Agonist | Molecular Endocrinology | 2003 | 460 |
| 20 | GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes | Endocrinology | 2013 | 455 |
| 21 | Correlation between Genetic and Geographic Structure in Europe | Current Biology | 2008 | 452 |
| 22 | Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature | Physiological Reviews | 2015 | 449 |
| 23 | GPCRdb in 2018: adding GPCR structure models and ligands | Nucleic Acids Research | 2018 | 449 |
| 24 | GPCR-Mediated Signaling of Metabolites | Cell Metabolism | 2017 | 437 |
| 25 | Computing the Local Field Potential (LFP) from Integrate-and-Fire Network Models | PLoS Computational Biology | 2015 | 413 |
| 26 | Generic GPCR residue numbers – aligning topology maps while minding the gaps | Trends in Pharmacological Sciences | 2015 | 411 |
| 27 | Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins | Nature Methods | 2010 | 406 |
| 28 | Modeling type 2 diabetes in rats using high fat diet and streptozotocin | Journal of Diabetes Investigation | 2014 | 406 |
| 29 | MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL | Annual Review of Pharmacology and Toxicology | 2006 | 388 |
| 30 | Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors | Nature Communications | 2012 | 386 |
| 31 | GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin | Endocrinology | 2007 | 374 |
| 32 | Iron trafficking inside the brain | Journal of Neurochemistry | 2007 | 372 |
| 33 | Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch | Science | 2004 | 364 |
| 34 | How curved membranes recruit amphipathic helices and protein anchoring motifs | Nature Chemical Biology | 2009 | 364 |
| 35 | The Hamilton Depression Scale | Acta Psychiatrica Scandinavica | 1981 | 359 |
| 36 | The effects of cardiovascular exercise on human memory: A review with meta-analysis | Neuroscience and Biobehavioral Reviews | 2013 | 359 |
| 37 | Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia | Science Advances | 2019 | 355 |
| 38 | Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression | Circulation | 2003 | 352 |
| 39 | Exercise Promotes Healthy Aging of Skeletal Muscle | Cell Metabolism | 2016 | 352 |
| 40 | Influence of Phasic and Tonic Dopamine Release on Receptor Activation | Journal of Neuroscience | 2010 | 350 |
| 41 | Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 | Nature Communications | 2017 | 349 |
| 42 | Conformational changes in the G protein Gs induced by the β2 adrenergic receptor | Nature | 2011 | 348 |
| 43 | High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring | Molecular Metabolism | 2016 | 331 |
| 44 | Systematic Review of the Incidence and Characteristics of Preventable Adverse Drug Events in Ambulatory Care | Annals of Pharmacotherapy | 2007 | 329 |
| 45 | Selectivity determinants of GPCR–G-protein binding | Nature | 2017 | 325 |
| 46 | The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy | Journal of Cerebral Blood Flow and Metabolism | 2017 | 324 |
| 47 | Ligand binding and micro-switches in 7TM receptor structures | Trends in Pharmacological Sciences | 2009 | 314 |
| 48 | Glycine transporters: essential regulators of neurotransmission | Trends in Biochemical Sciences | 2005 | 310 |
| 49 | The binding sites for cocaine and dopamine in the dopamine transporter overlap | Nature Neuroscience | 2008 | 308 |
| 50 | Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study | BMJ, The | 2021 | 307 |
