842
Articles
45.2K
Citations
6.6
avg. Impact Factor
96
h-index

Most Cited Articles of Cell and Systems Biology

TitleJournalYearCitations
Topological domains in mammalian genomes identified by analysis of chromatin interactionsNature20124.1K
Genome-Scale CRISPR-Mediated Control of Gene Repression and ActivationCell20141.6K
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas systemCell20131.3K
Chromatin architecture reorganization during stem cell differentiationNature2015988
Assembly of long, error-prone reads using repeat graphsNature Biotechnology2019897
A protein-tagging system for signal amplification in gene expression and fluorescence imagingCell2014874
A high-resolution map of the three-dimensional chromatin interactome in human cellsNature2013861
Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resourcesCell2014802
A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011Molecular Systems Biology2011726
Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome EngineeringCell2016715
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic ScreensCell2016675
Diet dominates host genotype in shaping the murine gut microbiotaCell Host and Microbe2015658
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffoldsCell2015648
Mechanisms and Regulation of Alternative Pre-mRNA SplicingAnnual Review of Biochemistry2015646
Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methodsNature Reviews Microbiology2012571
Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivoNature2014560
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein ResponseCell2016518
Moving in the Anthropocene: Global reductions in terrestrial mammalian movementsScience2018474
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2Cell2020454
A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human GenomeCell Reports2016453
Using Genome-scale Models to Predict Biological CapabilitiesCell2015433
Ribosome profiling reveals pervasive translation outside of annotated protein-coding genesCell Reports2014416
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cellsScience2017404
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen productionBlood2005385
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0Nature Protocols2019385