| Reduced number of hypocretin neurons in human narcolepsy | Neuron | 2000 | 1.6K |
| The eyes have it: the neuroethology, function and evolution of social gaze | Neuroscience and Biobehavioral Reviews | 2000 | 1.3K |
| Patterns of brain activation in people at risk for Alzheimer's disease | New England Journal of Medicine | 2000 | 1K |
| Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life | Journal of Clinical Oncology | 2000 | 814 |
| Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 610 |
| Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD | Nature Neuroscience | 2000 | 605 |
| Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder | Psychiatric Clinics of North America | 2000 | 595 |
| Origin and molecular specification of striatal interneurons | Journal of Neuroscience | 2000 | 513 |
| New insights into sympathetic regulation of glucose and fat metabolism | Diabetologia | 2000 | 401 |
| Controlled family study of anorexia nervosa and bulimia nervosa: evidence of shared liability and transmission of partial syndromes | American Journal of Psychiatry | 2000 | 371 |
| Neurocognitive Functioning of Adolescents: Effects of Protracted Alcohol Use | Alcoholism: Clinical and Experimental Research | 2000 | 354 |
| Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon | Behavioural Pharmacology | 2000 | 347 |
| Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 327 |
| Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits | American Journal of Psychiatry | 2000 | 311 |
| Methadone maintenance vs 180-day psychosocially enriched detoxification for treatment of opioid dependence: a randomized controlled trial | JAMA - Journal of the American Medical Association | 2000 | 281 |
| Two personalities, one relationship: Both partners' personality traits shape the quality of their relationship. | Journal of Personality and Social Psychology | 2000 | 276 |
| Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction | Neurology | 2000 | 275 |
| Gender differences in susceptibility to posttraumatic stress disorder | Behaviour Research and Therapy | 2000 | 272 |
| Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice | Endocrinology | 2000 | 250 |
| Subnucleus-specific loss of neurons in medial thalamus of schizophrenics | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 243 |
| Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain | Journal of Neurochemistry | 2000 | 242 |
| Posttraumatic stress disorder in the primary care medical setting | General Hospital Psychiatry | 2000 | 236 |
| Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo | European Journal of Haematology | 2000 | 229 |
| Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review | European Psychiatry | 2000 | 223 |
| Local protein synthesis and its role in synapse-specific plasticity | Current Opinion in Neurobiology | 2000 | 212 |
