| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease | Neurology | 1993 | 3,695 |
| 2 | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology | Canadian Journal of Gastroenterology and Hepatology | 2005 | 2,790 |
| 3 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 2,028 |
| 4 | Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma | Thyroid | 2015 | 1,832 |
| 5 | Dysphagia After Stroke | Stroke | 2005 | 1,612 |
| 6 | International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study | Lancet, The | 2018 | 1,570 |
| 7 | The Results of Radical Nephrectomy for Renal Cell Carcinoma | Journal of Urology | 1969 | 1,435 |
| 8 | Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety | American Journal of Clinical Nutrition | 1999 | 1,320 |
| 9 | Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice | Nature Medicine | 1997 | 1,276 |
| 10 | The prevalence of pituitary adenomas | Cancer | 2004 | 1,169 |
| 11 | PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project | Journal of Thoracic Oncology | 2017 | 1,100 |
| 12 | Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors | Hepatology | 1990 | 1,078 |
| 13 | The Database of Genomic Variants: a curated collection of structural variation in the human genome | Nucleic Acids Research | 2014 | 1,068 |
| 14 | Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration | Acta Neuropathologica | 2007 | 998 |
| 15 | Myocardial infarction accelerates atherosclerosis | Nature | 2012 | 898 |
| 16 | The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism | JAMA Surgery | 2016 | 895 |
| 17 | Preparation of Suspensions of Washed Platelets from Humans | British Journal of Haematology | 1972 | 845 |
| 18 | Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans | CRC Critical Reviews in Toxicology | 1983 | 839 |
| 19 | Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: A synopsis of the National Cancer Institute Thyroid Fine‐Needle Aspiration State of the Science Conference | Diagnostic Cytopathology | 2008 | 834 |
| 20 | New principle for the analysis of chemical carcinogenesis | Nature | 1976 | 831 |
| 21 | Pathogenetic mechanisms in thyroid follicular-cell neoplasia | Nature Reviews Cancer | 2006 | 808 |
| 22 | Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study | Journal of Clinical Oncology | 2002 | 806 |
| 23 | Complex N-Glycan Number and Degree of Branching Cooperate to Regulate Cell Proliferation and Differentiation | Cell | 2007 | 795 |
| 24 | Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source | New England Journal of Medicine | 2018 | 778 |
| 25 | High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Current Biology | 1998 | 763 |
| 26 | Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients | Science Immunology | 2020 | 745 |
| 27 | Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer | Cancer Discovery | 2018 | 729 |
| 28 | Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 | Modern Pathology | 2017 | 718 |
| 29 | EGFR Mutations and Lung Cancer | Annual Review of Pathology: Mechanisms of Disease | 2011 | 686 |
| 30 | Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21 | Journal of Clinical Oncology | 2008 | 676 |
| 31 | Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells | Nature Genetics | 2010 | 660 |
| 32 | Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme | Journal of Experimental Medicine | 2011 | 656 |
| 33 | The NINCDS‐ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease | Neurology | 1988 | 631 |
| 34 | PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project | Journal of Thoracic Oncology | 2018 | 630 |
| 35 | On the pathogenesis of focal nodular hyperplasia of the liver | Hepatology | 1985 | 623 |
| 36 | Acute Kidney Injury After Cardiac Surgery | Circulation | 2009 | 623 |
| 37 | Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial | Circulation | 2014 | 605 |
| 38 | Parathyroid Hormone Stimulates the Bone Apposition Rate Independently of Its Resorptive Action: Differential Effects of Intermittent and Continuous Administration* | Endocrinology | 1982 | 601 |
| 39 | micronodular transpormation (nodular regenerative hyperplasia) of the liver: A report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules | Hepatology | 1990 | 601 |
| 40 | Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum | Nature | 1998 | 601 |
| 41 | Disentangling Interactions in the Microbiome: A Network Perspective | Trends in Microbiology | 2017 | 598 |
| 42 | The urgent need to recommend an intake of vitamin D that is effective | American Journal of Clinical Nutrition | 2007 | 591 |
| 43 | Patterns of Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 Expression in Rabbit and Mouse Atherosclerotic Lesions and at Sites Predisposed to Lesion Formation | Circulation Research | 1999 | 582 |
| 44 | Mass Spectrometry as a Diagnostic and a Cancer Biomarker Discovery Tool | Molecular and Cellular Proteomics | 2004 | 573 |
| 45 | Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma | Cancer Cell | 2017 | 571 |
| 46 | Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level | American Journal of Clinical Nutrition | 2001 | 549 |
| 47 | Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations | Nature Genetics | 2014 | 549 |
| 48 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers | Clinical Chemistry | 2008 | 546 |
| 49 | The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 523 |
| 50 | The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease* | Endocrine Reviews | 2001 | 522 |
