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| 2 | International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors | Pharmacological Reviews | 2006 | 917 |
| 3 | Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport | Science | 2003 | 666 |
| 4 | PPARs at the crossroads of lipid signaling and inflammation | Trends in Endocrinology and Metabolism | 2012 | 607 |
| 5 | Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome | Nature Genetics | 2012 | 573 |
| 6 | β-Catenin hits chromatin: regulation of Wnt target gene activation | Nature Reviews Molecular Cell Biology | 2009 | 558 |
| 7 | Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 | American Journal of Medical Genetics, Part A | 2015 | 558 |
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| 9 | Oculocutaneous albinism | Orphanet Journal of Rare Diseases | 2007 | 483 |
| 10 | The rise and fall of Hox gene clusters | Development (Cambridge) | 2007 | 456 |
| 11 | A Switch Between Topological Domains Underlies
HoxD
Genes Collinearity in Mouse Limbs | Science | 2013 | 426 |
| 12 | The role of Hox genes during vertebrate limb development | Current Opinion in Genetics and Development | 2007 | 394 |
| 13 | The genomes of two key bumblebee species with primitive eusocial organization | Genome Biology | 2015 | 374 |
| 14 | Parafibromin/Hyrax Activates Wnt/Wg Target Gene Transcription by Direct Association with β-catenin/Armadillo | Cell | 2006 | 306 |
| 15 | Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function | Nature | 2005 | 256 |
| 16 | Mechanisms of the Anti-Obesity Effects of Oxytocin in Diet-Induced Obese Rats | PLoS ONE | 2011 | 240 |
| 17 | Structural and Functional Differences in the Long Non-Coding RNA Hotair in Mouse and Human | PLoS Genetics | 2011 | 220 |
| 18 | Control of Hoxd Genes' Collinearity during Early Limb Development | Developmental Cell | 2006 | 212 |
| 19 | Involvement of PPAR nuclear receptors in tissue injury and wound repair | Journal of Clinical Investigation | 2006 | 208 |
| 20 | Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH | Science | 2006 | 201 |
| 21 | The ABC of the BX-C: the bithorax complex explained | Development (Cambridge) | 2006 | 187 |
| 22 | Differentiation of Trophoblast Giant Cells and Their Metabolic Functions Are Dependent on Peroxisome Proliferator-Activated Receptor β/δ | Molecular and Cellular Biology | 2006 | 186 |
| 23 | Changes in Hox genes’ structure and function during the evolution of the squamate body plan | Nature | 2010 | 172 |
| 24 | Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease | Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids | 2007 | 161 |
| 25 | Altered aggregation properties of mutant γ-crystallins cause inherited cataract | EMBO Journal | 2002 | 154 |
| 26 | Histone Chaperones ASF1 and NAP1 Differentially Modulate Removal of Active Histone Marks by LID-RPD3 Complexes during NOTCH Silencing | Molecular Cell | 2009 | 150 |
| 27 | Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness | Genes and Development | 2008 | 142 |
| 28 | Interference of pollutants with PPARs: endocrine disruption meets metabolism | International Journal of Obesity | 2008 | 141 |
| 29 | The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms | Environmental Health Perspectives | 2010 | 141 |
| 30 | Loss of Egg Yolk Genes in Mammals and the Origin of Lactation and Placentation | PLoS Biology | 2008 | 140 |
| 31 | Fat poetry: a kingdom for PPARγ | Cell Research | 2007 | 139 |
| 32 | Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet | Diabetes | 2011 | 137 |
| 33 | Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes | Nature Genetics | 2005 | 130 |
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| 35 | Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification | Nature Genetics | 2006 | 120 |
| 36 | The Origin of Digits: Expression Patterns versus Regulatory Mechanisms | Developmental Cell | 2010 | 120 |
| 37 | Loss of tubulin deglutamylase
CCP
1 causes infantile‐onset neurodegeneration | EMBO Journal | 2018 | 115 |
| 38 | Regulatory constraints in the evolution of the tetrapod limb anterior–posterior polarity | Nature | 2006 | 114 |
| 39 | Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2 | Diabetes | 2008 | 113 |
| 40 | Major Depression: One Brain, One Disease, One Set of Intertwined Processes | Cells | 2021 | 113 |
| 41 | Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice | Journal of Clinical Investigation | 2009 | 112 |
| 42 | A mouse model for human short-stature syndromes identifies
Shox2
as an upstream regulator of
Runx2
during long-bone development | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 108 |
| 43 | Regulation of epithelial–mesenchymal IL-1 signaling by PPARβ/δ is essential for skin homeostasis and wound healing | Journal of Cell Biology | 2009 | 105 |
| 44 | PPARβ/δ Regulates Paneth Cell Differentiation Via Controlling the Hedgehog Signaling Pathway | Gastroenterology | 2006 | 103 |
| 45 | PPARs Mediate Lipid Signaling in Inflammation and Cancer | PPAR Research | 2008 | 102 |
| 46 | Cytogenetic analysis of 531 Chinese women with premature ovarian failure | Human Reproduction | 2012 | 102 |
| 47 | ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia | Blood | 2012 | 100 |
| 48 | Sucrose Preference Test as a Measure of Anhedonic Behavior in a Chronic Unpredictable Mild Stress Model of Depression: Outstanding Issues | Brain Sciences | 2022 | 99 |
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| 50 | PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism | Diabetologia | 2014 | 93 |
