| # | Title | Journal | Year | Citations |
|---|
|
| 1 | International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study | Lancet, The | 2018 | 1,570 |
| 2 | Targeting renal cell carcinoma with a HIF-2 antagonist | Nature | 2016 | 545 |
| 3 | Exosomal circRNAs: biogenesis, effect and application in human diseases | Molecular Cancer | 2019 | 465 |
| 4 | Endogenous toll‐like receptor ligands and their biological significance | Journal of Cellular and Molecular Medicine | 2010 | 463 |
| 5 | LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1 | Cancer Research | 2016 | 442 |
| 6 | Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression | Molecular Cancer | 2019 | 425 |
| 7 | Roles of F-box proteins in cancer | Nature Reviews Cancer | 2014 | 418 |
| 8 | PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma | Oncotarget | 2016 | 415 |
| 9 | Cytokine storm intervention in the early stages of COVID-19 pneumonia | Cytokine and Growth Factor Reviews | 2020 | 404 |
| 10 | PC3 is a cell line characteristic of prostatic small cell carcinoma | Prostate | 2011 | 381 |
| 11 | Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma | Cancer Discovery | 2012 | 350 |
| 12 | Overexpression of yes‐associated protein contributes to progression and poor prognosis of non‐small‐cell lung cancer | Cancer Science | 2010 | 310 |
| 13 | Effects of exosomes on pre-metastatic niche formation in tumors | Molecular Cancer | 2019 | 298 |
| 14 | Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus | Nature | 2014 | 297 |
| 15 | The emerging problem of linezolid-resistant Staphylococcus | Journal of Antimicrobial Chemotherapy | 2013 | 293 |
| 16 | circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a | Journal of Experimental and Clinical Cancer Research | 2017 | 284 |
| 17 | Boron delivery agents for neutron capture therapy of cancer | Cancer Communications | 2018 | 284 |
| 18 | Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16 | Molecular Cancer | 2015 | 281 |
| 19 | Dual-responsive biohybrid neutrobots for active target delivery | Science Robotics | 2021 | 280 |
| 20 | Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1 | Molecular Cancer | 2017 | 278 |
| 21 | Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis | Gut | 2019 | 268 |
| 22 | Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation | Theranostics | 2020 | 248 |
| 23 | A circRNA–miRNA–mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma | Journal of Translational Medicine | 2018 | 242 |
| 24 | Pancreatic cancer: A review of epidemiology, trend, and risk factors | World Journal of Gastroenterology | 2021 | 237 |
| 25 | Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma | Hepatology | 2013 | 236 |
| 26 | CD155T/TIGIT Signaling Regulates CD8+ T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer | Cancer Research | 2017 | 235 |
| 27 | miR-146a Inhibits Cell Growth, Cell Migration and Induces Apoptosis in Non-Small Cell Lung Cancer Cells | PLoS ONE | 2013 | 233 |
| 28 | Upregulation of p53 Expression in Patients with Colorectal Cancer by Administration of Curcumin | Cancer Investigation | 2011 | 232 |
| 29 | Novel lignin–chitosan–PVA composite hydrogel for wound dressing | Materials Science and Engineering C | 2019 | 221 |
| 30 | A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1 | Molecular Cancer | 2019 | 221 |
| 31 | Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling | Nature Cell Biology | 2021 | 214 |
| 32 | Association of Vimentin overexpression and hepatocellular carcinoma metastasis | Oncogene | 2004 | 208 |
| 33 | Nanostructure Embedded Microchips for Detection, Isolation, and Characterization of Circulating Tumor Cells | Accounts of Chemical Research | 2014 | 205 |
| 34 | Identification of miRs-143 and -145 that Is Associated with Bone Metastasis of Prostate Cancer and Involved in the Regulation of EMT | PLoS ONE | 2011 | 201 |
| 35 | Anti-malarial agent artesunate inhibits TNF- -induced production of proinflammatory cytokines via inhibition of NF- B and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes | Rheumatology | 2007 | 199 |
| 36 | Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells | BMC Cancer | 2010 | 194 |
| 37 | Machine learning-based analysis of MR radiomics can help to improve the diagnostic performance of PI-RADS v2 in clinically relevant prostate cancer | European Radiology | 2017 | 194 |
| 38 | Pathologist-level interpretable whole-slide cancer diagnosis with deep learning | Nature Machine Intelligence | 2019 | 194 |
| 39 | LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling | Cell Death and Disease | 2018 | 193 |
| 40 | lncRNA DANCR promotes tumor progression and cancer stemness features in osteosarcoma by upregulating AXL via miR-33a-5p inhibition | Cancer Letters | 2017 | 191 |
| 41 | LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer | Cell Death and Disease | 2015 | 184 |
| 42 | Bone marrow stem cells‐derived microvesicles protect against renal injury in the mouse remnant kidney model | Nephrology | 2012 | 182 |
| 43 | Increased expression of programmed death (PD)‐1 and its ligand PD‐L1 correlates with impaired cell‐mediated immunity in high‐risk human papillomavirus‐related cervical intraepithelial neoplasia | Immunology | 2013 | 179 |
| 44 | Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy | Frontiers in Immunology | 2020 | 176 |
| 45 | The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression | Cancer Cell | 2014 | 174 |
| 46 | The Glycolytic Switch in Tumors: How Many Players Are Involved? | Journal of Cancer | 2017 | 171 |
| 47 | MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1 | Cardiovascular Research | 2011 | 169 |
| 48 | Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations | Nature Genetics | 2012 | 168 |
| 49 | Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer | Medical Oncology | 2014 | 166 |
| 50 | Convolutional neural network for the diagnosis of early gastric cancer based on magnifying narrow band imaging | Gastric Cancer | 2020 | 165 |
