| # | Title | Journal | Year | Citations |
|---|
|
| 1 | COVID-19: Melatonin as a potential adjuvant treatment | Life Sciences | 2020 | 502 |
| 2 | Melatonin Synthesis and Function: Evolutionary History in Animals and Plants | Frontiers in Endocrinology | 2019 | 449 |
| 3 | Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas | Cellular and Molecular Life Sciences | 2017 | 399 |
| 4 | The mammalian pineal gland: Structure and function | American Journal of Anatomy | 1981 | 272 |
| 5 | Cross-talk among writers, readers, and erasers of m 6 A regulates cancer growth and progression | Science Advances | 2018 | 259 |
| 6 | Nocturnal Elevation of Plasma Melatonin and Urinary 5-Hydroxyindoleacetic Acid in Young Men: Attempts at Modification by Brief Changes in Environmental Lighting and Sleep and by Autonomic Drugs | Journal of Clinical Endocrinology and Metabolism | 1976 | 191 |
| 7 | Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease | Nature Communications | 2020 | 166 |
| 8 | Melatonin and sirtuins: A “not‐so unexpected” relationship | Journal of Pineal Research | 2017 | 155 |
| 9 | Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland | Molecules | 2018 | 146 |
| 10 | Melatonin protects against maternal obesity‐associated oxidative stress and meiotic defects in oocytes via the SIRT3‐SOD2‐dependent pathway | Journal of Pineal Research | 2017 | 140 |
| 11 | Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation | Journal of Pineal Research | 2018 | 140 |
| 12 | The Suppression of Pineal Melatonin Content andN-AcetyItransferase Activity by Different Light Irradiances in the Syrian Hamster: A Dose-Response Relationship* | Endocrinology | 1983 | 138 |
| 13 | An evolutionary view of melatonin synthesis and metabolism related to its biological functions in plants | Journal of Experimental Botany | 2020 | 138 |
| 14 | Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells | Melatonin Research | 2019 | 134 |
| 15 | Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis | Nature Communications | 2017 | 129 |
| 16 | HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice | Cancer Cell | 2019 | 128 |
| 17 | Phytomelatonin: An Emerging Regulator of Plant Biotic Stress Resistance | Trends in Plant Science | 2021 | 120 |
| 18 | Pineal Melatonin Concentrations in the Syrian Hamster* | Endocrinology | 1979 | 118 |
| 19 | Quantification of Daily Melatonin Synthesis in the Hamster Pineal Gland* | Endocrinology | 1980 | 118 |
| 20 | Exogenous and endogenous control of the annual reproductive cycle in the male golden hamster: Participation of the pineal gland | The Journal of Experimental Zoology | 1975 | 117 |
| 21 | Role of melatonin in controlling angiogenesis under physiological and pathological conditions | Angiogenesis | 2020 | 117 |
| 22 | Neurogenesis in the aging brain | Biochemical Pharmacology | 2017 | 114 |
| 23 | Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response | Cancer Research | 2018 | 97 |
| 24 | Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19 | Life Sciences | 2020 | 96 |
| 25 | A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer | Molecular Cell | 2019 | 93 |
| 26 | Daily rhythms of phytomelatonin signaling modulate diurnal stomatal closure via regulating reactive oxygen species dynamics in Arabidopsis | Journal of Pineal Research | 2020 | 91 |
| 27 | Melatonin administration to wild‐type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis | Journal of Pineal Research | 2017 | 90 |
| 28 | Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance | Nature Cell Biology | 2020 | 90 |
| 29 | Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3 | International Journal of Molecular Sciences | 2018 | 87 |
| 30 | Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19 | Frontiers in Medicine | 2020 | 84 |
| 31 | Melatonin and its derivatives counteract the ultraviolet B radiation‐induced damage in human and porcine skin ex vivo | Journal of Pineal Research | 2018 | 82 |
| 32 | Androgen Receptors in the Brain: What Are We Measuring?* | Endocrine Reviews | 1983 | 81 |
| 33 | Melatonin inhibits seed germination by crosstalk with abscisic acid, gibberellin, and auxin in Arabidopsis | Journal of Pineal Research | 2021 | 81 |
| 34 | A GABAergic Influence on the Light-Induced Increase in Dopamine Turnover in the Dark-Adapted Rat Retina In Vivo | Journal of Neurochemistry | 1980 | 80 |
| 35 | Histophysiological evidence for the secretion of polypeptides by the pineal gland | American Journal of Anatomy | 1975 | 78 |
| 36 | Neurobiological perspective of 22q11.2 deletion syndrome | Lancet Psychiatry,the | 2019 | 76 |
| 37 | Localization of antisera to LH? and FSH? in the rat pituitary gland | American Journal of Anatomy | 1975 | 72 |
| 38 | Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival | Scientific Reports | 2019 | 70 |
| 39 | The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation | Genome Biology | 2020 | 67 |
| 40 | Cell proliferation in injured spinal cord. An electron microscopic study | Journal of Comparative Neurology | 1973 | 65 |
| 41 | miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer | Cell Death and Disease | 2018 | 65 |
| 42 | Melatonin Inhibits COVID-19-induced Cytokine Storm by Reversing Aerobic Glycolysis in Immune Cells: A Mechanistic Analysis | Medicine in Drug Discovery | 2020 | 64 |
| 43 | Melatonin as a promising agent to treat ovarian cancer: molecular mechanisms | Carcinogenesis | 2017 | 61 |
| 44 | A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection | PLoS Pathogens | 2018 | 59 |
| 45 | Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children's Oncology Group Phase 1 Consortium study (ADVL1411) | Pediatric Blood and Cancer | 2020 | 58 |
| 46 | HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia | Molecular Cell | 2022 | 58 |
| 47 | MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma | Nature Communications | 2018 | 57 |
| 48 | Interval and continuous exercise overcome memory deficits related to β-Amyloid accumulation through modulating mitochondrial dynamics | Behavioural Brain Research | 2019 | 57 |
| 49 | Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis | Cellular and Molecular Life Sciences | 2020 | 56 |
| 50 | Treatment of ebola and other infectious diseases: melatonin “goes viral” | Melatonin Research | 2020 | 56 |
