| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Principles of nanoparticle design for overcoming biological barriers to drug delivery | Nature Biotechnology | 2015 | 5,199 |
| 2 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,886 |
| 3 | Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET | Nature Medicine | 2012 | 3,189 |
| 4 | Integrative Clinical Genomics of Advanced Prostate Cancer | Cell | 2015 | 2,809 |
| 5 | Points of control in inflammation | Nature | 2002 | 2,296 |
| 6 | Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver | Nature Cell Biology | 2015 | 2,155 |
| 7 | Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors | Blood | 2000 | 2,101 |
| 8 | Evidence for Circulating Bone Marrow-Derived Endothelial Cells | Blood | 1998 | 1,587 |
| 9 | Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis | ELife | 2013 | 1,575 |
| 10 | A comparative encyclopedia of DNA elements in the mouse genome | Nature | 2014 | 1,546 |
| 11 | Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis | Cancer Cell | 2016 | 1,489 |
| 12 | Evolution of antibody immunity to SARS-CoV-2 | Nature | 2021 | 1,455 |
| 13 | Pre-metastatic niches: organ-specific homes for metastases | Nature Reviews Cancer | 2017 | 1,356 |
| 14 | Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages | Journal of Experimental Medicine | 2003 | 1,336 |
| 15 | Double-stranded DNA in exosomes: a novel biomarker in cancer detection | Cell Research | 2014 | 1,332 |
| 16 | Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent | Cell | 1997 | 1,327 |
| 17 | XRCC3 promotes homology-directed repair of DNA damage in mammalian cells | Genes and Development | 1999 | 1,199 |
| 18 | Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation | Nature Cell Biology | 2018 | 1,177 |
| 19 | High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor | Nature | 1991 | 1,176 |
| 20 | Brca1 Controls Homology-Directed DNA Repair | Molecular Cell | 1999 | 1,146 |
| 21 | The metastatic niche: adapting the foreign soil | Nature Reviews Cancer | 2009 | 1,105 |
| 22 | Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study | Blood | 2002 | 1,100 |
| 23 | Histone deacetylase inhibitor selectively induces p21 WAF1 expression and gene-associated histone acetylation | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 1,057 |
| 24 | Cancer metabolism: fatty acid oxidation in the limelight | Nature Reviews Cancer | 2013 | 1,016 |
| 25 | ADAMs: key components in EGFR signalling and development | Nature Reviews Molecular Cell Biology | 2005 | 1,002 |
| 26 | Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright | Journal of Molecular Biology | 2001 | 998 |
| 27 | Epithelial Mesenchymal Transition in Tumor Metastasis | Annual Review of Pathology: Mechanisms of Disease | 2018 | 984 |
| 28 | The perivascular niche regulates breast tumour dormancy | Nature Cell Biology | 2013 | 973 |
| 29 | CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism | Journal of Clinical Investigation | 2001 | 968 |
| 30 | Derivation of midbrain dopamine neurons from human embryonic stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 932 |
| 31 | Identification of erythroferrone as an erythroid regulator of iron metabolism | Nature Genetics | 2014 | 928 |
| 32 | From The Cover: Training, maturation, and genetic influences on the development of executive attention | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 924 |
| 33 | Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination | Science | 2004 | 913 |
| 34 | Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation | Cell Reports | 2014 | 894 |
| 35 | Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer | Journal of Clinical Oncology | 2005 | 877 |
| 36 | Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice | Journal of Clinical Investigation | 2000 | 875 |
| 37 | Exosome-Mediated Metastasis: Communication from a Distance | Developmental Cell | 2019 | 871 |
| 38 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers | Cell | 2020 | 787 |
| 39 | Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine | Cancer Discovery | 2017 | 769 |
| 40 | Molecular Characterization of Neuroendocrine Prostate Cancer and Identification of New Drug Targets | Cancer Discovery | 2011 | 762 |
| 41 | The lung microenvironment: an important regulator of tumour growth and metastasis | Nature Reviews Cancer | 2019 | 751 |
| 42 | Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 | Nature | 1996 | 749 |
| 43 | Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells | Nature Biotechnology | 2013 | 741 |
| 44 | Phase I Trial of the Proteasome Inhibitor PS-341 in Patients With Refractory Hematologic Malignancies | Journal of Clinical Oncology | 2002 | 727 |
| 45 | Neurotrophin receptors: A window into neuronal differentiation | Neuron | 1992 | 717 |
| 46 | Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 697 |
| 47 | Chromatin states define tumour-specific T cell dysfunction and reprogramming | Nature | 2017 | 697 |
| 48 | A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism | Journal of Biological Chemistry | 1999 | 684 |
| 49 | XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway | Nature | 2014 | 679 |
| 50 | Connecting copper and cancer: from transition metal signalling to metalloplasia | Nature Reviews Cancer | 2022 | 648 |
