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Top Articles

#TitleJournalYearCitations
1Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProceedings of the National Academy of Sciences of the United States of America200541,381
2The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer's and Dementia201113,319
3Analysis of protein-coding genetic variation in 60,706 humansNature20169,271
4Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelinesJournal of Extracellular Vesicles20187,596
5Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseAlzheimer's and Dementia20115,740
6Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,789
7Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersNature Cell Biology20084,400
8Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseNature19953,923
9Pathobiology of ischaemic stroke: an integrated viewTrends in Neurosciences19993,533
10International consensus diagnostic criteria for neuromyelitis optica spectrum disordersNeurology20153,463
11Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working GroupJournal of Clinical Oncology20103,320
12Guidelines for the use and interpretation of assays for monitoring autophagyAutophagy20123,158
13Neuronal ensemble control of prosthetic devices by a human with tetraplegiaNature20063,019
14The cerebellar cognitive affective syndromeBrain19982,710
15The Alzheimer's disease neuroimaging initiative (ADNI): MRI methodsJournal of Magnetic Resonance Imaging20082,655
16Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in BrainScience19972,593
17Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseNature Medicine19962,573
18Neuropathological Alterations in Alzheimer DiseaseCold Spring Harbor Perspectives in Medicine20112,482
19A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 ProfilesCell20172,457
20The World Health Organization adult ADHD self-report scale (ASRS): a short screening scale for use in the general populationPsychological Medicine20052,415
21Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral SclerosisScience20092,349
22A polymorphic DNA marker genetically linked to Huntington's diseaseNature19832,307
23Neuropathological Classification of Huntingtonʼs DiseaseJournal of Neuropathology and Experimental Neurology19852,302
24Reach and grasp by people with tetraplegia using a neurally controlled robotic armNature20122,250
25Prediction of central nervous system embryonal tumour outcome based on gene expressionNature20022,167
26Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processingNature Genetics20192,145
27Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD MutationCell19972,121
28National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approachActa Neuropathologica20122,114
29National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's diseaseAlzheimer's and Dementia20122,089
30Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-TetrahydropyridineJournal of Neuroscience20002,033
31A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's diseaseAlzheimer's and Dementia20142,006
32The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functionsJournal of Experimental Medicine20071,999
33Hypertension in mice lacking the gene for endothelial nitric oxide synthaseNature19951,945
34The brain basis of emotion: A meta-analytic reviewBehavioral and Brain Sciences20121,848
35Functional topography in the human cerebellum: A meta-analysis of neuroimaging studiesNeuroImage20091,840
36Tau Suppression in a Neurodegenerative Mouse Model Improves Memory FunctionScience20051,803
37Temporal Relations of Atrial Fibrillation and Congestive Heart Failure and Their Joint Influence on MortalityCirculation20031,758
38Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's diseaseNature Genetics20111,719
39AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma PatientsCancer Cell20071,687
40The Science of Stroke: Mechanisms in Search of TreatmentsNeuron20101,674
41Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic PerspectiveCell20051,671
42Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the LiteratureJournal of Neuropathology and Experimental Neurology20121,663
43Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene databaseNature Genetics20071,645
44Mechanisms, challenges and opportunities in strokeNature Reviews Neuroscience20031,613
45An Integrative Model of Cellular States, Plasticity, and Genetics for GlioblastomaCell20191,588
46Cerebral microbleeds: a guide to detection and interpretationLancet Neurology, The20091,532
47Neuronal subtype specification in the cerebral cortexNature Reviews Neuroscience20071,470
48Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic MiceNeuron20011,433
49Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivoProceedings of the National Academy of Sciences of the United States of America20031,345
50The epidemiology of Parkinson's disease: risk factors and preventionLancet Neurology, The20161,332