| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 9,050 |
| 2 | Zebrafish: An Emerging Model System for Human Disease and Drug Discovery | Clinical Pharmacology and Therapeutics | 2007 | 438 |
| 3 | The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices | Biochemical Journal | 1994 | 371 |
| 4 | Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis | Development (Cambridge) | 1994 | 334 |
| 5 | Molecular mechanisms of biological aging in intervertebral discs | Journal of Orthopaedic Research | 2016 | 328 |
| 6 | Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms | Annual Review of Pathology: Mechanisms of Disease | 2012 | 263 |
| 7 | Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting | Journal of Orthopaedic Research | 2015 | 247 |
| 8 | Biological interplay between proteoglycans and their innate immune receptors in inflammation | FEBS Journal | 2013 | 239 |
| 9 | The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore | Aging Cell | 2017 | 230 |
| 10 | Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment | International Journal of Biochemistry and Cell Biology | 2011 | 225 |
| 11 | Updating the diagnosis, classification and assessment of rosacea: recommendations from the global
ROS
acea
CO
nsensus (
ROSCO
) panel | British Journal of Dermatology | 2017 | 222 |
| 12 | Tendon Functional Extracellular Matrix | Journal of Orthopaedic Research | 2015 | 221 |
| 13 | Identification of Incidental Sequence Polymorphisms and Absence of the db/db Mouse and fa/fa Rat Mutations | Diabetes | 1996 | 214 |
| 14 | Decorin Binds to a Narrow Region of the Epidermal Growth Factor (EGF) Receptor, Partially Overlapping but Distinct from the EGF-binding Epitope | Journal of Biological Chemistry | 2002 | 210 |
| 15 | Human keratin diseases:. Hereditary fragility of specific epithelial tissues | Experimental Dermatology | 1996 | 209 |
| 16 | Asynchrony among local communities stabilises ecosystem function of metacommunities | Ecology Letters | 2017 | 195 |
| 17 | Understanding the "lethal" drivers of tumor-stroma co-evolution | Cancer Biology and Therapy | 2010 | 192 |
| 18 | Colchicine: an ancient drug with novel applications | British Journal of Dermatology | 2018 | 189 |
| 19 | Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin | Nature Genetics | 2001 | 175 |
| 20 | Recommendations for rosacea diagnosis, classification and management: update from the global
ROS
acea
CO
nsensus 2019 panel | British Journal of Dermatology | 2020 | 174 |
| 21 | Klippel–Trenaunay syndrome belongs to the PIK3CA‐related overgrowth spectrum (PROS) | Experimental Dermatology | 2016 | 172 |
| 22 | FOXA1: master of steroid receptor function in cancer | EMBO Journal | 2011 | 171 |
| 23 | The autophagic tumor stroma model of cancer or “battery-operated tumor growth” | Cell Cycle | 2010 | 168 |
| 24 | Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels | Cell | 2018 | 167 |
| 25 | Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment | Breast Cancer Research | 2011 | 164 |
| 26 | Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells | Cancer Biology and Therapy | 2011 | 161 |
| 27 | Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells | Cancer Biology and Therapy | 2011 | 157 |
| 28 | The Spectrum of Pathogenic Mutations in SPINK5 in 19 Families with Netherton Syndrome: Implications for Mutation Detection and First Case of Prenatal Diagnosis | Journal of Investigative Dermatology | 2001 | 153 |
| 29 | Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate | Neuron | 1994 | 151 |
| 30 | Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria | Cell Metabolism | 2012 | 148 |
| 31 | Perlecan: A gem of a proteoglycan | Matrix Biology | 1994 | 141 |
| 32 | Proteoglycan neofunctions: regulation of inflammation and autophagy in cancer biology | FEBS Journal | 2017 | 141 |
| 33 | Rosacea treatment update: recommendations from the global
ROS
acea
CO
nsensus (
ROSCO
) panel | British Journal of Dermatology | 2017 | 140 |
| 34 | 2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections | Journal of Orthopaedic Research | 2019 | 132 |
| 35 | Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration | Matrix Biology | 2018 | 131 |
| 36 | Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention? | BMC Medicine | 2011 | 129 |
| 37 | Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth | Oncotarget | 2012 | 129 |
| 38 | Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment | Cancer Biology and Therapy | 2011 | 127 |
| 39 | Evidence for Novel Functions of the Keratin Tail Emerging from a Mutation Causing Ichthyosis Hystrix | Journal of Investigative Dermatology | 2001 | 123 |
| 40 | Mechanism of growth inhibition by MicroRNA 145: The role of the IGF‐I receptor signaling pathway | Journal of Cellular Physiology | 2009 | 122 |
| 41 | Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases | Experimental Dermatology | 2021 | 116 |
| 42 | Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1α–BNIP3 Axis | Journal of Bone and Mineral Research | 2020 | 115 |
| 43 | The Human Decorin Gene: Intron-Exon Organization, Discovery of Two Alternatively Spliced Exons in the 5′ Untranslated Region, and Mapping of the Gene to Chromosome 12q23 | Genomics | 1993 | 113 |
| 44 | Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth | Cancer Biology and Therapy | 2011 | 113 |
| 45 | Genetic Heterogeneity of KID Syndrome: Identification of a Cx30 Gene (GJB6) Mutation in a Patient with KID Syndrome and Congenital Atrichia | Journal of Investigative Dermatology | 2004 | 106 |
| 46 | Probing nanoparticle interactions in cell culture media | Colloids and Surfaces B: Biointerfaces | 2012 | 106 |
| 47 | Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne | Journal of the American Academy of Dermatology | 2019 | 98 |
| 48 | Adjuvant antibiotic‐loaded bone cement: Concerns with current use and research to make it work | Journal of Orthopaedic Research | 2021 | 97 |
| 49 | Nuclear Factor-κB Mediates TNF-α Inhibitory Effect on α2(I) Collagen (COL1A2) Gene Transcription in Human Dermal Fibroblasts | Journal of Immunology | 1999 | 95 |
| 50 | Stretch-induced Calcium Release in Smooth Muscle | Journal of General Physiology | 2002 | 93 |
