| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 9,284 |
| 2 | Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles | Journal of Extracellular Vesicles | 2014 | 2,438 |
| 3 | Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper | Journal of Extracellular Vesicles | 2017 | 657 |
| 4 | Wnt5a regulates distinct signalling pathways by binding to Frizzled2 | EMBO Journal | 2010 | 301 |
| 5 | Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility | Journal of Extracellular Vesicles | 2017 | 204 |
| 6 | Efficient TALEN construction and evaluation methods for human cell and animal applications | Genes To Cells | 2013 | 199 |
| 7 | Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation is Associated with a Reduced Risk of Relapse in Patients with Acute Myeloid Leukemia Who Survived to Day 100 after Transplantation: The Japan Society for Hematopoietic Cell Transplantation Transplantation-related Complication Working Group | Biology of Blood and Marrow Transplantation | 2015 | 181 |
| 8 | Dose—response of a Radiation Induction of a Germline Mutation at a Hypervariable Mouse Minisatellite Locus | International Journal of Radiation Biology | 1995 | 122 |
| 9 | Depletion of Uric Acid Due to SLC22A12 (URAT1) Loss-of-Function Mutation Causes Endothelial Dysfunction in Hypouricemia | Circulation Journal | 2015 | 111 |
| 10 | Development of miRNA‐based therapeutic approaches for cancer patients | Cancer Science | 2019 | 110 |
| 11 | Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD‐J (Flow‐Mediated Dilation Japan) Study A | Journal of the American Heart Association | 2018 | 103 |
| 12 | Diagnostic Criteria of Flow‐Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin‐Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery | Journal of the American Heart Association | 2020 | 102 |
| 13 | Ribosomal proteins of bacterial cells: Strain- and species-specificity | Journal of Molecular Biology | 1968 | 100 |
| 14 | Isolation of <i>Nitrospira</i> belonging to Sublineage II from a Wastewater Treatment Plant | Microbes and Environments | 2013 | 93 |
| 15 | Optineurin suppression causes neuronal cell death via NF‐κB pathway | Journal of Neurochemistry | 2013 | 88 |
| 16 | Ribosomes from erythromycin-resistant mutants of Escherichia coli Q13 | Journal of Molecular Biology | 1970 | 71 |
| 17 | Evolution of 5sRNA | Journal of Molecular Evolution | 1975 | 68 |
| 18 | Release of ribosomal proteins from Escherichia coli ribosomes with high concentrations of lithium chloride | Journal of Molecular Biology | 1968 | 64 |
| 19 | Isolation of sublineage I Nitrospira by a novel cultivation strategy | Environmental Microbiology | 2014 | 64 |
| 20 | A randomized Phase III trial of lobe-specific vs. systematic nodal dissection for clinical Stage I–II non-small cell lung cancer (JCOG1413) | Japanese Journal of Clinical Oncology | 2018 | 63 |
| 21 | Telomerase Expression in Noncancerous Bronchial Epithelia Is a Possible Marker of Early Development of Lung Cancer | Cancer Research | 2005 | 62 |
| 22 | Stem cell‐derived conditioned media from human exfoliated deciduous teeth promote bone regeneration | Oral Diseases | 2020 | 62 |
| 23 | OCCUPATIONAL FACTORS IN THE EPIDEMIOLOGY OF LEUKEMIA IN HIROSHIMA AND NAGASAKI1 | American Journal of Epidemiology | 1971 | 60 |
| 24 | Genome‐wide association study in musician's dystonia: A risk variant at the arylsulfatase G locus? | Movement Disorders | 2014 | 58 |
| 25 | TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of
BUB1B
as causative of PCS (MVA) syndrome | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 55 |
| 26 | Association of Insulin Resistance, Plasma Glucose Level, and Serum Insulin Level With Hypertension in a Population With Different Stages of Impaired Glucose Metabolism | Journal of the American Heart Association | 2020 | 53 |
| 27 | Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration | Aging Cell | 2020 | 50 |
| 28 | Generation of albino Xenopus tropicalis using zinc‐finger nucleases | Development Growth and Differentiation | 2012 | 49 |
| 29 | Predicting the presence of breast cancer using circulating small RNAs, including those in the extracellular vesicles | Cancer Science | 2020 | 49 |
| 30 | Optineurin and amyotrophic lateral sclerosis | Geriatrics and Gerontology International | 2013 | 47 |
| 31 | Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis | Stem Cells Translational Medicine | 2018 | 47 |
| 32 | Robust molecular phylogeny and palaeodistribution modelling resolve a complex evolutionary history: glacial cycling drove recurrent mtDNA introgression among Pelophylax frogs in East Asia | Journal of Biogeography | 2015 | 46 |
| 33 | Clinicopathologic features of autosomal recessive amyotrophic lateral sclerosis associated with optineurin mutation | Neuropathology | 2014 | 43 |
| 34 | Effects of the masticatory demand on the rat mandibular development | Journal of Oral Rehabilitation | 2014 | 43 |
| 35 | Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome | EMBO Journal | 2020 | 43 |
| 36 | Copy number variation in DRC1 is the major cause of primary ciliary dyskinesia in the Japanese population | Molecular Genetics & Genomic Medicine | 2020 | 42 |
| 37 | Hyperuricemia is independently associated with endothelial dysfunction in postmenopausal women but not in premenopausal women | BMJ Open | 2013 | 41 |
| 38 | Selective Enrichment of Two Different Types of <i>Nitrospira</i>-like Nitrite-oxidizing Bacteria from a Wastewater Treatment Plant | Microbes and Environments | 2013 | 41 |
| 39 | Treatment Outcomes and Prognostic Factors After Recurrence of Esophageal Squamous Cell carcinoma | World Journal of Surgery | 2017 | 38 |
| 40 | The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation | Oncogene | 2015 | 36 |
| 41 | Saturated fatty acids accelerate linear motility through mitochondrial ATP production in bull sperm | Reproductive Medicine and Biology | 2021 | 36 |
| 42 | Individual and joint impact of family history and Helicobacter pylori infection on the risk of stomach cancer: a nested case–control study | British Journal of Cancer | 2004 | 35 |
| 43 | Tyrosine kinase inhibitor prophylaxis after transplant for Philadelphia chromosome‐positive acute lymphoblastic leukemia | Cancer Science | 2019 | 35 |
| 44 | Inhibition of PAI‐1 limits chemotherapy resistance in lung cancer through suppressing myofibroblast characteristics of cancer‐associated fibroblasts | Journal of Cellular and Molecular Medicine | 2019 | 35 |
| 45 | Regulation of thyroid hormone sensitivity by differential expression of the thyroid hormone receptor during Xenopus metamorphosis | Genes To Cells | 2012 | 34 |
| 46 | Emergence of resistant variants detected by ultra‐deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1 | Journal of Viral Hepatitis | 2015 | 34 |
| 47 | Novel oral transforming growth factor‐β signaling inhibitor EW‐7197 eradicates CML‐initiating cells | Cancer Science | 2016 | 34 |
| 48 | Role of Postoperative C‐Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer | World Journal of Surgery | 2017 | 34 |
| 49 | Utility and pitfalls of immunohistochemistry in the differential diagnosis between epithelioid mesothelioma and poorly differentiated lung squamous cell carcinoma | Histopathology | 2017 | 32 |
| 50 | Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress | Cell Biology International | 2020 | 32 |
