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1Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancerScience20156,756
2Tumor mutational load predicts survival after immunotherapy across multiple cancer typesNature Genetics20192,702
3Long Noncoding RNAs in Cancer PathwaysCancer Cell20162,584
4Genes that mediate breast cancer metastasis to lungNature20052,581
5Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patientsNature Medicine20172,473
6Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosisNature19961,789
7Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid CarcinomaThyroid20151,738
8CD8+ T cells regulate tumour ferroptosis during cancer immunotherapyNature20191,528
9Tumor and Microenvironment Evolution during Immunotherapy with NivolumabCell20171,515
10Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in MiceScience20011,194
11INT 0123 (Radiation Therapy Oncology Group 94-05) Phase III Trial of Combined-Modality Therapy for Esophageal Cancer: High-Dose Versus Standard-Dose Radiation TherapyJournal of Clinical Oncology20021,153
12Chromosomal instability drives metastasis through a cytosolic DNA responseNature20181,002
13INT 0123 (Radiation Therapy Oncology Group 94-05) Phase III Trial of Combined-Modality Therapy for Esophageal Cancer: High-Dose Versus Standard-Dose Radiation TherapyJournal of Clinical Oncology2002981
14Comprehensive QA for radiation oncology: Report of AAPM Radiation Therapy Committee Task Group 40Medical Physics1994974
15Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformalityInternational Journal of Radiation Oncology Biology Physics2000885
16Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancerInternational Journal of Radiation Oncology Biology Physics1998876
17Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.Journal of Experimental Medicine1994853
18Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regenerationNature2015818
19Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced ApoptosisCell1996780
20Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signaturesGenome Biology2016746
21A novel response of cancer cells to radiation involves autophagy and formation of acidic vesiclesCancer Research2001739
22High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patientsInternational Journal of Radiation Oncology Biology Physics2002727
23Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytomaInternational Journal of Radiation Oncology Biology Physics1989724
25Incidence of Late Rectal and Urinary Toxicities After Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Localized Prostate CancerInternational Journal of Radiation Oncology Biology Physics2008622
26The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesotheliomaNature Genetics2011617
27ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approachAnnals of Oncology2019614
28Intensity-Modulated Radiation Therapy With or Without Chemotherapy for Nasopharyngeal Carcinoma: Radiation Therapy Oncology Group Phase II Trial 0225Journal of Clinical Oncology2009607
29Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumorsJournal of Clinical Investigation2005606
30The NOMS Framework: Approach to the Treatment of Spinal Metastatic TumorsOncologist2013570
31Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapyNature Medicine2000552
32Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalationInternational Journal of Radiation Oncology Biology Physics1999545
33A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapyNature2017532
34An Integrated Metabolic Atlas of Clear Cell Renal Cell CarcinomaCancer Cell2016531
35High-Dose, Single-Fraction Image-Guided Intensity-Modulated Radiotherapy for Metastatic Spinal LesionsInternational Journal of Radiation Oncology Biology Physics2008513
36Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host DiseaseImmunity2012509
37Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancerRadiotherapy and Oncology2000490
38Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging TherapiesCancer Discovery2017490
39Modern Radiation Therapy for Hodgkin Lymphoma: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group (ILROG)International Journal of Radiation Oncology Biology Physics2014479
40PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumorsNature Genetics2014472
41Radiation and ceramide-induced apoptosisOncogene2003460
42International Spine Radiosurgery Consortium Consensus Guidelines for Target Volume Definition in Spinal Stereotactic RadiosurgeryInternational Journal of Radiation Oncology Biology Physics2012457
43Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinomaCancer2015447
44Improved Clinical Outcomes With High-Dose Image Guided Radiotherapy Compared With Non-IGRT for the Treatment of Clinically Localized Prostate CancerInternational Journal of Radiation Oncology Biology Physics2012445
45Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non–Small-Cell Lung CancerJournal of Clinical Oncology2022445
46Multi-institutional analysis of long-term outcome for stages T1–T2 prostate cancer treated with permanent seed implantationInternational Journal of Radiation Oncology Biology Physics2007440
47Long-Term Outcome of High Dose Intensity Modulated Radiation Therapy for Patients With Clinically Localized Prostate CancerJournal of Urology2006422
48Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinomaCancer2003418
49Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide GenerationJournal of Experimental Medicine1997412
50Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal CancerJAMA Oncology2018404