| # | Title | Journal | Year | Citations |
|---|
|
| 1 | The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data | Cancer Discovery | 2012 | 13,521 |
| 2 | The Cancer Genome Atlas Pan-Cancer analysis project | Nature Genetics | 2013 | 6,646 |
| 3 | Microenvironmental regulation of tumor progression and metastasis | Nature Medicine | 2013 | 6,059 |
| 4 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus | Cell | 2003 | 5,370 |
| 5 | TGF-β SIGNAL TRANSDUCTION | Annual Review of Biochemistry | 1998 | 4,634 |
| 6 | Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease | Cell | 2017 | 4,514 |
| 7 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,451 |
| 8 | The Emerging Hallmarks of Cancer Metabolism | Cell Metabolism | 2016 | 4,213 |
| 9 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 4,133 |
| 10 | EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 4,131 |
| 11 | Cancer Metastasis: Building a Framework | Cell | 2006 | 3,773 |
| 12 | Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation | Nature | 2013 | 3,599 |
| 13 | A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing | Cell | 2007 | 3,428 |
| 14 | TGFβ in Cancer | Cell | 2008 | 3,385 |
| 15 | Human MicroRNA Targets | PLoS Biology | 2004 | 3,311 |
| 16 | Integrative Genomic Profiling of Human Prostate Cancer | Cancer Cell | 2010 | 3,221 |
| 17 | Microenvironmental regulation of metastasis | Nature Reviews Cancer | 2009 | 3,204 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,158 |
| 19 | Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling | Nature Biotechnology | 2009 | 3,144 |
| 20 | MicroRNA targets in Drosophila | Genome Biology | 2003 | 3,134 |
| 21 | Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain | PLoS Medicine | 2005 | 3,046 |
| 22 | Ferroptosis: mechanisms, biology and role in disease | Nature Reviews Molecular Cell Biology | 2021 | 2,862 |
| 23 | TGFβ signalling in context | Nature Reviews Molecular Cell Biology | 2012 | 2,723 |
| 24 | Somatic mutations affect key pathways in lung adenocarcinoma | Nature | 2008 | 2,718 |
| 25 | mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery | Cell | 2002 | 2,717 |
| 26 | Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate | Cancer Cell | 2012 | 2,700 |
| 27 | Genes that mediate breast cancer metastasis to lung | Nature | 2005 | 2,611 |
| 28 | Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton | Current Biology | 2004 | 2,402 |
| 29 | A multigenic program mediating breast cancer metastasis to bone | Cancer Cell | 2003 | 2,356 |
| 30 | Metastasis: from dissemination to organ-specific colonization | Nature Reviews Cancer | 2009 | 2,328 |
| 31 | The microRNA.org resource: targets and expression | Nucleic Acids Research | 2007 | 2,317 |
| 32 | Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes | Nature | 1985 | 2,315 |
| 33 | TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders | Cell | 2000 | 2,267 |
| 34 | Mechanism of activation of the TGF-β receptor | Nature | 1994 | 2,252 |
| 35 | Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver | Nature Cell Biology | 2015 | 2,155 |
| 36 | Smad transcription factors | Genes and Development | 2005 | 2,104 |
| 37 | Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors | Blood | 2000 | 2,101 |
| 38 | Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals | Cell | 1994 | 2,073 |
| 39 | CSF-1R inhibition alters macrophage polarization and blocks glioma progression | Nature Medicine | 2013 | 1,907 |
| 40 | Histone demethylation by a family of JmjC domain-containing proteins | Nature | 2006 | 1,884 |
| 41 | T cell exclusion, immune privilege, and the tumor microenvironment | Science | 2015 | 1,829 |
| 42 | OpenMM 7: Rapid development of high performance algorithms for molecular dynamics | PLoS Computational Biology | 2017 | 1,798 |
| 43 | Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth | Nature Medicine | 2001 | 1,794 |
| 44 | NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system | EMBO Journal | 2000 | 1,791 |
| 45 | Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis | Nature | 2005 | 1,788 |
| 46 | Dicer is essential for mouse development | Nature Genetics | 2003 | 1,773 |
| 47 | How cells read TGF-β signals | Nature Reviews Molecular Cell Biology | 2000 | 1,761 |
| 48 | Endogenous human microRNAs that suppress breast cancer metastasis | Nature | 2008 | 1,756 |
| 49 | p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. | Genes and Development | 1994 | 1,739 |
| 50 | IDH mutation impairs histone demethylation and results in a block to cell differentiation | Nature | 2012 | 1,739 |
