Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens | Cell | 2016 | 675 |
Activation of proto-oncogenes by disruption of chromosome neighborhoods | Science | 2016 | 600 |
The 3D Genome as Moderator of Chromosomal Communication | Cell | 2016 | 558 |
A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response | Cell | 2016 | 518 |
Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution | Cell | 2016 | 444 |
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria | Cell | 2016 | 367 |
CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs | Cell Stem Cell | 2016 | 271 |
Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression | Molecular Cell | 2016 | 207 |
TAD disruption as oncogenic driver | Current Opinion in Genetics and Development | 2016 | 127 |
Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode | Nature | 2016 | 110 |
CRISPR Immunological Memory Requires a Host Factor for Specificity | Molecular Cell | 2016 | 101 |
Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming | Cell Stem Cell | 2016 | 92 |
Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus | American Journal of Human Genetics | 2016 | 91 |
Zika Virus Infection Induces Cranial Neural Crest Cells to Produce Cytokines at Levels Detrimental for Neurogenesis | Cell Host and Microbe | 2016 | 79 |
Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 76 |
Architecture of retinal projections to the central circadian pacemaker | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 76 |
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering | ACS Chemical Biology | 2016 | 72 |
A bacterial Argonaute with noncanonical guide RNA specificity | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 67 |
SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells | Genome Research | 2016 | 64 |
RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells | Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms | 2016 | 43 |
Mapping the 3D genome: Aiming for consilience | Nature Reviews Molecular Cell Biology | 2016 | 40 |
Dynamic translation regulation in Caulobacter cell cycle control | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 33 |
Encoding four gene expression programs in the activation dynamics of a single transcription factor | Current Biology | 2016 | 31 |
An automated workflow for parallel processing of large multiview SPIM recordings | Bioinformatics | 2016 | 28 |
Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development | Journal of Visualized Experiments | 2016 | 21 |