| 1 | A simulation study of the number of events per variable in logistic regression analysis | Journal of Clinical Epidemiology | 1996 | 6,736 |
| 2 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 3,453 |
| 3 | Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 Studies | American Journal of Human Genetics | 2003 | 2,499 |
| 4 | Qualitative Data Analysis for Health Services Research: Developing Taxonomy, Themes, and Theory | Health Services Research | 2007 | 2,411 |
| 5 | Metabolomics: beyond biomarkers and towards mechanisms | Nature Reviews Molecular Cell Biology | 2016 | 2,124 |
| 6 | A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury | New England Journal of Medicine | 1990 | 1,877 |
| 7 | Importance of events per independent variable in proportional hazards regression analysis II. Accuracy and precision of regression estimates | Journal of Clinical Epidemiology | 1995 | 1,639 |
| 8 | Longitudinal analyses reveal immunological misfiring in severe COVID-19 | Nature | 2020 | 1,476 |
| 9 | Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease | Nature Genetics | 1994 | 1,434 |
| 10 | Recognition of single-stranded RNA viruses by Toll-like receptor 7 | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 1,283 |
| 11 | Transgender stigma and health: A critical review of stigma determinants, mechanisms, and interventions | Social Science and Medicine | 2015 | 1,196 |
| 12 | Stereotype Embodiment | Current Directions in Psychological Science | 2009 | 1,191 |
| 13 | Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG Adherence Instruments | AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV | 2000 | 1,131 |
| 14 | Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society | Movement Disorders | 2018 | 1,105 |
| 15 | Phylogeny and PCR–based classification of Wolbachia strains using wsp gene sequences | Proceedings of the Royal Society B: Biological Sciences | 1998 | 1,018 |
| 16 | Nurturing care: promoting early childhood development | Lancet, The | 2017 | 1,014 |
| 17 | Bats: Important Reservoir Hosts of Emerging Viruses | Clinical Microbiology Reviews | 2006 | 979 |
| 18 | Designing for a green chemistry future | Science | 2020 | 977 |
| 19 | Sex differences in immune responses that underlie COVID-19 disease outcomes | Nature | 2020 | 974 |
| 20 | MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment | Nature Medicine | 2007 | 970 |
| 21 | Sex-Based Differences in Early Mortality after Myocardial Infarction | New England Journal of Medicine | 1999 | 911 |
| 22 | Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study | Diabetologia | 1999 | 870 |
| 23 | Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma | Nature Genetics | 2012 | 866 |
| 24 | How to increase value and reduce waste when research priorities are set | Lancet, The | 2014 | 864 |
| 25 | Epidemiology and etiology of meningioma | Journal of Neuro-Oncology | 2010 | 849 |
| 26 | The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs | Molecular Cell | 2013 | 820 |
| 27 | Analysis of Transcription Factor HY5 Genomic Binding Sites Revealed Its Hierarchical Role in Light Regulation of Development | Plant Cell | 2007 | 812 |
| 28 | The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms | Lancet, The | 2023 | 773 |
| 29 | Immunity-Related Genes and Gene Families inAnopheles gambiae | Science | 2002 | 761 |
| 30 | Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size | Annals of Thoracic Surgery | 2002 | 756 |
| 31 | Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics | Nature Biotechnology | 2020 | 754 |
| 32 | A Comparison of Linkage Disequilibrium Measures for Fine-Scale Mapping | Genomics | 1995 | 743 |
| 33 | The Role of Social Relations in Health Promotion | Psychosomatic Medicine | 1995 | 728 |
| 34 | Release of Infectious Epstein-Barr Virus by Transformed Marmoset Leukocytes | Proceedings of the National Academy of Sciences of the United States of America | 1973 | 714 |
| 35 | Prevalence and Penetrance of Germline BRCA1 and BRCA2 Mutations in a Population Series of 649 Women with Ovarian Cancer | American Journal of Human Genetics | 2001 | 710 |
| 36 | Fear of Falling and Fall-Related Efficacy in Relationship to Functioning Among Community-Living Elders | Journal of Gerontology | 1994 | 684 |
| 37 | Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges | Blood Reviews | 2019 | 684 |
| 38 | Diverse functional autoantibodies in patients with COVID-19 | Nature | 2021 | 678 |
| 39 | Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women | JAMA - Journal of the American Medical Association | 2001 | 677 |
| 40 | De novo mutations in histone-modifying genes in congenital heart disease | Nature | 2013 | 675 |
| 41 | Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies | Lancet Oncology, The | 2012 | 669 |
| 42 | Health Perceptions and Survival: Do Global Evaluations of Health Status Really Predict Mortality? | Journal of Gerontology | 1991 | 665 |
| 43 | The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis | Neuropsychopharmacology | 2004 | 659 |
| 44 | The Impact of Food Prices on Consumption: A Systematic Review of Research on the Price Elasticity of Demand for Food | American Journal of Public Health | 2010 | 656 |
| 45 | Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung Cancer | JAMA Oncology | 2016 | 650 |
| 46 | Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence | JAMA - Journal of the American Medical Association | 2015 | 649 |
| 47 | Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction | Cancer | 1994 | 647 |
| 48 | DEPRESSIVE SYMPTOMS IN RELATION TO PHYSICAL HEALTH AND FUNCTIONING IN THE ELDERLY | American Journal of Epidemiology | 1986 | 646 |
| 49 | Text Messaging as a Tool for Behavior Change in Disease Prevention and Management | Epidemiologic Reviews | 2010 | 646 |
| 50 | Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure | Journal of the American College of Cardiology | 2004 | 645 |