| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,789 |
| 2 | Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics | Nature Reviews Gastroenterology and Hepatology | 2017 | 3,493 |
| 3 | Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood | Nature Medicine | 2007 | 1,972 |
| 4 | Stress granules and processing bodies are dynamically linked sites of mRNP remodeling | Journal of Cell Biology | 2005 | 1,269 |
| 5 | Placental development: Lessons from mouse mutants | Nature Reviews Genetics | 2001 | 1,155 |
| 6 | Placental-specific IGF-II is a major modulator of placental and fetal growth | Nature | 2002 | 978 |
| 7 | The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics | Nature Reviews Gastroenterology and Hepatology | 2020 | 935 |
| 8 | Quorum sensing in Escherichia coli , Salmonella typhimurium , and Vibrio harveyi : A new family of genes responsible for autoinducer production | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 870 |
| 9 | The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response | Nature | 2008 | 849 |
| 10 | Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs | PLoS ONE | 2014 | 823 |
| 11 | Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial | Lancet Respiratory Medicine,the | 2016 | 811 |
| 12 | Structures and metal-ion-binding properties of the Ca2+-binding helix–loop–helix EF-hand motifs | Biochemical Journal | 2007 | 765 |
| 13 | Communication in bacteria: an ecological and evolutionary perspective | Nature Reviews Microbiology | 2006 | 695 |
| 14 | Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults | American Journal of Clinical Nutrition | 2009 | 598 |
| 15 | Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining | Biochemical Journal | 2009 | 593 |
| 16 | 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial | Lancet, The | 2017 | 543 |
| 17 | Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo | Blood | 2002 | 532 |
| 18 | Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments | Nature Methods | 2019 | 514 |
| 19 | Gridlock signalling pathway fashions the first embryonic artery | Nature | 2001 | 506 |
| 20 | Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication | Molecular Microbiology | 2003 | 472 |
| 21 | Development of Structures and Transport Functions in the Mouse Placenta | Physiology | 2005 | 472 |
| 22 | 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults | Canadian Journal of Cardiology | 2021 | 462 |
| 23 | Regulation of Protein Kinase B/Akt-Serine 473 Phosphorylation by Integrin-linked Kinase | Journal of Biological Chemistry | 2001 | 435 |
| 24 | The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 424 |
| 25 | Disruption of GW bodies impairs mammalian RNA interference | Nature Cell Biology | 2005 | 423 |
| 26 | Expanding antigen-specific regulatory networks to treat autoimmunity | Nature | 2016 | 423 |
| 27 | Nanoparticle-Based Immunotherapy for Cancer | ACS Nano | 2015 | 413 |
| 28 | DNA damage-induced activation of ATM and ATM-dependent signaling pathways | DNA Repair | 2004 | 411 |
| 29 | Gender and telomere length: Systematic review and meta-analysis | Experimental Gerontology | 2014 | 410 |
| 30 | REAP: A two minute cell fractionation method | BMC Research Notes | 2010 | 405 |
| 31 | Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis | Circulation Research | 2011 | 403 |
| 32 | The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta | Nature Genetics | 2000 | 392 |
| 33 | Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis | Nature Medicine | 2012 | 385 |
| 34 | The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase | Nature | 2003 | 380 |
| 35 | Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity | Gastroenterology | 2017 | 378 |
| 36 | The effect of thick fibers and large pores of electrospun poly(ε-caprolactone) vascular grafts on macrophage polarization and arterial regeneration | Biomaterials | 2014 | 375 |
| 37 | Extra-embryonic function of Rb is essential for embryonic development and viability | Nature | 2003 | 373 |
| 38 | Differential Activation of Innate Immune Responses by Adenovirus and Adeno-Associated Virus Vectors | Journal of Virology | 2002 | 370 |
| 39 | Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport | Biochemical Journal | 2007 | 361 |
| 40 | Selected glimpses into the activation and function of Src kinase | Oncogene | 2000 | 359 |
| 41 | Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta | Developmental Biology | 2007 | 356 |
| 42 | Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature | Developmental Cell | 2004 | 353 |
| 43 | Multi-omics profiling of mouse gastrulation at single-cell resolution | Nature | 2019 | 344 |
| 44 | Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain | Science | 2004 | 343 |
| 45 | Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type | Nature Genetics | 2006 | 338 |
| 46 | Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy | Nature | 2017 | 336 |
| 47 | Disruption ofacvrl1increases endothelial cell number in zebrafish cranial vessels | Development (Cambridge) | 2002 | 335 |
| 48 | Repair of DNA double strand breaks by non-homologous end joining | Biochimie | 2003 | 334 |
| 49 | Rescue of cleft palate inMsx1-deficient mice by transgenicBmp4reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis | Development (Cambridge) | 2002 | 332 |
| 50 | Molecular mechanisms underlying cell fate specification in the developing telencephalon | Current Opinion in Neurobiology | 2002 | 327 |
