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Top Articles

#TitleJournalYearCitations
1CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor GrowthCancer Cell20111,062
2Insights into Land Plant Evolution Garnered from the Marchantia polymorpha GenomeCell20171,048
3Understanding Oxidative Stress and Antioxidant Functions to Enhance PhotosynthesisPlant Physiology20111,009
4Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatmentProceedings of the National Academy of Sciences of the United States of America2013687
5Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody CetuximabScience Translational Medicine2011557
6A carbonic anhydrase from the nacreous layer in oyster pearls.Proceedings of the National Academy of Sciences of the United States of America1996514
7Animal‐cell culture media: History, characteristics, and current issuesReproductive Medicine and Biology2017340
8Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cellNature Communications2012333
9Analysis and experimental assessment of the sensitivity of stimulated Raman scattering microscopyOptics Express2009281
10Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisiteCarcinogenesis2002278
11Probing Conformational Fluctuation of Proteins by Pressure PerturbationChemical Reviews2006271
12Electrolyzed Water as a Disinfectant for Fresh-cut VegetablesJournal of Food Science1999270
13Establishment of embryonic stem cell lines from cynomolgus monkey blastocysts produced by IVF or ICSIDevelopmental Dynamics2001265
14Tumor immune microenvironment and nivolumab efficacy in EGFR mutation-positive non-small-cell lung cancer based on T790M status after disease progression during EGFR-TKI treatmentAnnals of Oncology2017250
15Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2Proceedings of the National Academy of Sciences of the United States of America2006248
16Antibody‐dependent cellular cytotoxicity of cetuximab against tumor cells with wild‐type or mutant epidermal growth factor receptorCancer Science2007240
17A plastidial sodium-dependent pyruvate transporterNature2011230
18Mobilization of a transposon in the rice genomeNature2003229
19Intravenous Infusion of Syngeneic Apoptotic Cells by Photopheresis Induces Antigen-Specific Regulatory T CellsJournal of Immunology2005217
20Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenanceJournal of Experimental Medicine2016204
21Molecular Genetic Tools and Techniques forMarchantia polymorphaResearchPlant and Cell Physiology2016204
22Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA)British Journal of Cancer2007199
23A transient pool of nuclear F-actin at mitotic exit controls chromatin organizationNature Cell Biology2017184
24The Carbonic Anhydrase Domain Protein Nacrein is Expressed in the Epithelial Cells of the Mantle and Acts as a Negative Regulator in Calcification in the Mollusc Pinctada fucataZoological Science2005174
25FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor GrowthCancer Research2010172
26Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive HeterochromatinCurrent Biology2020172
27EGFR Exon 18 Mutations in Lung Cancer: Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First- or Third-Generation TKIsClinical Cancer Research2015171
28xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell CarcinomaCancer Research2013166
29Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiPJournal of Biological Chemistry2008165
30FcγR2A and 3A polymorphisms predict clinical outcome of trastuzumab in both neoadjuvant and metastatic settings in patients with HER2-positive breast cancerAnnals of Oncology2011163
31FGFR2 gene amplification and clinicopathological features in gastric cancerBritish Journal of Cancer2012163
32Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancerBritish Journal of Cancer2011156
33Activation of HER Family Signaling as a Mechanism of Acquired Resistance to ALK Inhibitors in EML4-ALK–Positive Non–Small Cell Lung CancerClinical Cancer Research2012150
34Auraptene, a Citrus Coumarin, Inhibits 12-0-Tetradecanoylphorbol-13-acetate-induced Tumor Promotion in ICR Mouse Skin, Possibly through Suppression of Superoxide Generation in LeukocytesJapanese Journal of Cancer Research1997149
35Induction of Prophages of Enterohemorrhagic Escherichia coli O157:H7 with NorfloxacinJournal of Bacteriology1999146
36Impact of Pretreatment Interstitial Lung Disease on Radiation Pneumonitis and Survival after Stereotactic Body Radiation Therapy for Lung CancerJournal of Thoracic Oncology2015144
37Bivalve-specific gene expansion in the pearl oyster genome: implications of adaptation to a sessile lifestyleZoological Letters2016140
38Complementary DNA Cloning and Characterization of Pearlin, a New Class of Matrix Protein in the Nacreous Layer of Oyster PearlsMarine Biotechnology2000138
39mTOR Signal and Hypoxia-Inducible Factor-1α Regulate CD133 Expression in Cancer CellsCancer Research2009137
40DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's diseaseScientific Reports2014136
41From The Cover: Functional expression of a  12 fatty acid desaturase gene from spinach in transgenic pigsProceedings of the National Academy of Sciences of the United States of America2004134
42FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinomaHepatology2013133
43CD44+ slow‐cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesisCancer Science2010132
44Role of ERK-BIM and STAT3-Survivin Signaling Pathways in ALK Inhibitor–Induced Apoptosis in EML4-ALK–Positive Lung CancerClinical Cancer Research2011132
45Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colonNature Communications2021130
46Clock and ATF4 transcription system regulates drug resistance in human cancer cell linesOncogene2007127
47Anti-tumor Promotion with Food Phytochemicals: A Strategy for Cancer ChemopreventionBioscience, Biotechnology and Biochemistry1996126
48DS‐8201a, a new HER2‐targeting antibody–drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2‐positive gastric cancer T‐DM1 resistanceInternational Journal of Cancer2017126
49Emerging ethnic differences in lung cancer therapyBritish Journal of Cancer2008124
502-Antiplasmin Gene Deficiency in Mice Is Associated With Enhanced Fibrinolytic Potential Without Overt BleedingBlood1999121