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Top Articles

#TitleJournalYearCitations
1TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue PhysiologyCold Spring Harbor Perspectives in Biology20161,070
2Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumorsNature Medicine2014778
3Navigating metabolic pathways to enhance antitumour immunity and immunotherapyNature Reviews Clinical Oncology2019545
4T memory stem cells in health and diseaseNature Medicine2017508
5Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometryNature Communications2016505
6Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patientsProceedings of the National Academy of Sciences of the United States of America2015465
7Regulatory circuits of T cell function in cancerNature Reviews Immunology2016409
8Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to ImmunotherapyCancer Discovery2022366
9Chromothripsis drives the evolution of gene amplification in cancerNature2020333
10T cell–induced CSF1 promotes melanoma resistance to PD1 blockadeScience Translational Medicine2018247
11Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cellsJournal of Clinical Investigation2018234
12Macrophage-derived glutamine boosts satellite cells and muscle regenerationNature2020224
13T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?Nature Reviews Immunology2014219
14Mechanisms of TGFβ-Induced Epithelial–Mesenchymal TransitionJournal of Clinical Medicine2016215
15Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanomaScience Translational Medicine2017189
16Metabolic Control of CD8+ T Cell Fate Decisions and Antitumor ImmunityTrends in Molecular Medicine2018187
17Inhibitory Receptors Beyond T Cell ExhaustionFrontiers in Immunology2015177
18Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunityCellular and Molecular Immunology2020161
19Transforming machine translation: a deep learning system reaches news translation quality comparable to human professionalsNature Communications2020144
20A generic strategy for CRISPR-Cas9-mediated gene taggingNature Communications2015141
21Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterationsNature Communications2016122
22Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivoScience Translational Medicine2015121
23Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive ImmunotherapyACS Nano2015117
24The cytokine-serum amyloid A-chemokine networkCytokine and Growth Factor Reviews2016116
25Molecular profiling of CD 8 T cells in autochthonous melanoma identifies Maf as driver of exhaustionEMBO Journal2015103
26Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patientsJournal of Experimental Medicine2019103
27Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell TransplantationCell Stem Cell2017102
28Mutational signature distribution varies with DNA replication timing and strand asymmetryGenome Biology2018100
29JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasionNucleic Acids Research201889
30Very Late Antigen-1 Marks Functional Tumor-Resident CD8 T Cells and Correlates with Survival of Melanoma PatientsFrontiers in Immunology201688
31Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T CellsEBioMedicine201688
32ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic CellsFrontiers in Immunology201787
33CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancerNature201583
34The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosomeNature Communications201981
35Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients—Report of a Phase I/IIa Clinical TrialClinical Cancer Research201676
36The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island ChromatinCell Reports201774
37The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of GranzymesCell Reports201774
38A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiencyClinical and Experimental Immunology201471
39Estimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome*Molecular and Cellular Proteomics201870
40Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich’s “magic (nano)bullet” for cancer theranostics?Cancer Treatment Reviews201668
41‘Hotspots’ of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen PrioritizationFrontiers in Immunology201767
42Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycleNature Immunology201962
43Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeysNature Communications202062
44Autocrine Adenosine Regulates Tumor Polyfunctional CD73+CD4+ Effector T Cells Devoid of Immune CheckpointsCancer Research201860
45Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeatsNature202360
46Transient genomic instability drives tumorigenesis through accelerated clonal evolutionGenes and Development202159
47Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanomaOncoImmunology053
48The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors201552
49The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28–Costimulated T Cells Prepared for Adoptive TherapyClinical Cancer Research201552
50Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients201952