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Top Articles

#TitleJournalYearCitations
1Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiotaNature20151,586
2Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compoundsJournal of Virological Methods19881,472
3The neuroactive potential of the human gut microbiota in quality of life and depressionNature Microbiology20191,455
4An index of substitution saturation and its applicationMolecular Phylogenetics and Evolution20031,278
5Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell ActivationJournal of Biological Chemistry20031,269
6Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathwaysNature Neuroscience20131,105
7Approved Antiviral Drugs over the Past 50 YearsClinical Microbiology Reviews20161,064
8CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicityNature Neuroscience2001844
9Clades of Adeno-Associated Viruses Are Widely Disseminated in Human TissuesJournal of Virology2004790
10Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG)Archives of Virology2011776
11Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1Nature Medicine2002770
12Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 UpdatePLoS ONE2009753
13Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)Critical Reviews in Biochemistry and Molecular Biology2002743
14Full Genome-Based Classification of Rotaviruses Reveals a Common Origin between Human Wa-Like and Porcine Rotavirus Strains and Human DS-1-Like and Bovine Rotavirus StrainsJournal of Virology2008739
15Antiviral drugs in current clinical useJournal of Clinical Virology2004715
16Further additions to MolScript version 1.4, including reading and contouring of electron-density mapsActa Crystallographica Section D: Biological Crystallography1999684
17N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2Cell2021650
18Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivativesNature1990648
19A novel selective broad-spectrum anti-DNA virus agentNature1986641
20Toward Improved Anti-HIV Chemotherapy: Therapeutic Strategies for Intervention with HIV InfectionsJournal of Medicinal Chemistry1995630
21The CC chemokine CCL20 and its receptor CCR6Cytokine and Growth Factor Reviews2003618
22Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decadeCritical Reviews in Biochemistry and Molecular Biology2013617
23Response of Serum Interleukin-6 in Patients Undergoing Elective Surgery of Varying SeverityClinical Science1990599
24Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseasesNature Reviews Drug Discovery2007587
25AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptorNature Medicine1998565
26Macrophage inflammatory protein-1Cytokine and Growth Factor Reviews2002543
27Therapeutic strategies for COVID-19: progress and lessons learnedNature Reviews Drug Discovery2023543
28Antiviral agents active against influenza A virusesNature Reviews Drug Discovery2006541
29Acyclic nucleoside phosphonates: a key class of antiviral drugsNature Reviews Drug Discovery2005540
30HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human CellsJournal of Biological Chemistry2003521
31Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intactBlood2000514
32Angiogenesis: regulators and clinical applicationsBiochemical Pharmacology2001505
33Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell CultureAntimicrobial Agents and Chemotherapy2014502
34Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical DevelopmentProcesses2021498
35Strategies in the design of antiviral drugsNature Reviews Drug Discovery2002496
36Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculatureNature Communications2015480
37Pyrimidine as Constituent of Natural Biologically Active CompoundsChemistry and Biodiversity2005459
38The role of CXC chemokines and their receptors in cancerCancer Letters2008455
39Human T-lymphotropic virus 1: recent knowledge about an ancient infectionLancet Infectious Diseases, The2007451
40Zoonotic aspects of rotavirusesVeterinary Microbiology2010449
41Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazideEuropean Journal of Pharmaceutical Sciences1999447
42Theranostic Fluorescent ProbesChemical Reviews2024446
43Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapyBritish Journal of Pharmacology2006438
44Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratioEMBO Journal2010438
45Sulfated polysaccharides are potent and selective inhibitors of various enveloped viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus, and human immunodeficiency virusAntimicrobial Agents and Chemotherapy1988435
46Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in HumansFrontiers in Public Health2018434
47SPREAD: spatial phylogenetic reconstruction of evolutionary dynamicsBioinformatics2011431
48Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitisJournal of Experimental Medicine2006429
49α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity AssessmentJournal of Medicinal Chemistry2020429
50The early spread and epidemic ignition of HIV-1 in human populationsScience2014428