| 1 | Model-based Analysis of ChIP-Seq (MACS) | Genome Biology | 2008 | 13,539 |
| 2 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,286 |
| 3 | The biology, function, and biomedical applications of exosomes | Science | 2020 | 9,176 |
| 4 | Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine | New England Journal of Medicine | 2021 | 7,955 |
| 5 | Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease | New England Journal of Medicine | 2017 | 7,440 |
| 6 | A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping | Cell | 2014 | 7,014 |
| 7 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 5,746 |
| 8 | feature articles\(\def\hfill{\hskip 5em}\def\hfil{\hskip 3em}\def\eqno#1{\hfil {#1}}\) | Acta Crystallographica Section D: Structural Biology | 2019 | 5,709 |
| 9 | Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform. | Applied and Environmental Microbiology | 2013 | 5,617 |
| 10 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 5,598 |
| 11 | Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results† | Movement Disorders | 2008 | 5,564 |
| 12 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 5,333 |
| 13 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 4,484 |
| 14 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. | Cell | 1993 | 4,409 |
| 15 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 4,283 |
| 16 | Genome-wide atlas of gene expression in the adult mouse brain | Nature | 2006 | 4,141 |
| 17 | UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses | Neoplasia | 2017 | 4,133 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,122 |
| 19 | Sequencing technologies — the next generation | Nature Reviews Genetics | 2009 | 4,090 |
| 20 | Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis | Gastroenterology | 2007 | 3,881 |
| 21 | The Somatic Genomic Landscape of Glioblastoma | Cell | 2013 | 3,781 |
| 22 | Parkinson’s disease: clinical features and diagnosis | Journal of Neurology, Neurosurgery and Psychiatry | 2008 | 3,647 |
| 23 | Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 | Nature Genetics | 1999 | 3,503 |
| 24 | Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours | Nature | 1992 | 3,401 |
| 25 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,280 |
| 26 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 3,184 |
| 27 | National Sleep Foundation’s sleep time duration recommendations: methodology and results summary | Sleep Health | 2015 | 3,174 |
| 28 | Silver staining of proteins in polyacrylamide gels | Analytical Biochemistry | 1981 | 3,139 |
| 29 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 3,088 |
| 30 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin | Nature | 2000 | 3,060 |
| 31 | The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. | Journal of Clinical Endocrinology and Metabolism | 2011 | 2,838 |
| 32 | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion | Cell | 2005 | 2,746 |
| 33 | Hepatocellular Carcinoma | New England Journal of Medicine | 2011 | 2,730 |
| 34 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 2,726 |
| 35 | Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. | Journal of the American College of Cardiology | 2017 | 2,723 |
| 36 | Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy | Cell | 2005 | 2,700 |
| 37 | Genomic analyses identify molecular subtypes of pancreatic cancer | Nature | 2016 | 2,680 |
| 38 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 2,654 |
| 39 | Regulation of p53 stability by Mdm2 | Nature | 1997 | 2,608 |
| 40 | Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome | Cell | 1991 | 2,597 |
| 41 | Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments | Cell Systems | 2016 | 2,553 |
| 42 | Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. | Clinical Infectious Diseases | 2011 | 2,531 |
| 43 | The repertoire of mutational signatures in human cancer | Nature | 2020 | 2,514 |
| 44 | Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients | Nature Medicine | 2017 | 2,513 |
| 45 | Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders | Cell | 2013 | 2,427 |
| 46 | Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases | Nature | 2019 | 2,421 |
| 47 | Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes. | Nucleic Acids Research | 1991 | 2,415 |
| 48 | EMAN2: An extensible image processing suite for electron microscopy | Journal of Structural Biology | 2007 | 2,365 |
| 49 | Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis | Gastroenterology | 2017 | 2,360 |
| 50 | Oncogenic Signaling Pathways in The Cancer Genome Atlas | Cell | 2018 | 2,328 |