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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Characterizing the Functional Similarity of Enzymes with High Co-Citation in Interaction Networks

Author(s): Lilla Tothmeresz and Vince Grolmusz

Volume 20, Issue 10, 2013

Page: [1181 - 1187] Pages: 7

DOI: 10.2174/0929866511320100013

Price: $65

Abstract

New methods for reliable quantitative analysis of biological network data are in high demand in today’s bioinformatics and systems biology. Here we demonstrate the applicability of the co-citation, developed earlier for the analysis of scientific literature for finding functionally similar nodes in protein-protein interaction networks in several model organisms. We prove the power of our approach in a novel way: the predicted closely related enzymes are compared to the closeness of their enzyme commission (EC) numbers, therefore we can numerically evaluate our prediction method. We have found clear correspondence between related enzymatic functions and high co-citation of proteins in interaction networks.

Keywords: Co-citation, protein interaction networks, vertex similarity.

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