Abstract
Tadalafil is one of the approved phosphodiesterase type 5 inhibitors, which are used in the treatment of erectile dysfunction. Few cases of intracerebral hemorrhage have been reported in the English literature, post-ingestion of PDE-5 inhibitor. We present a case of a previously healthy 35-year-old man, presenting for acute onset of severe headache post-ingestion of tadalafil to enhance his sexual performance. CT brain showed the presence of subarachnoid hemorrhage, and angiography eliminated the presence of vascular malformation. We believe that this is the 5th and youngest case of intracerebral hemorrhage post-tadalafil ingestion.
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Abbreviations
- Angio:
-
angiography
- AVM:
-
arteriovenous malformation
- Ca:
-
cancer
- cGMP:
-
cyclic guanosine monophosphate
- CT:
-
computed tomography
- ED:
-
erectile dysfunction
- FDA:
-
Food and Drug Administration
- HTN:
-
hypertension
- IC:
-
intracranial
- INR:
-
international normalized ratio
- M:
-
male
- NO:
-
nitric oxide
- N/A:
-
not available
- PDE-5:
-
phosphodiesterase type 5
- SH:
-
subarachnoid hemorrhage
References
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El-Helou, E., Naccour, J. Subarachnoid Hemorrhage After Precoital Tadalafil Use: a Case Report. SN Compr. Clin. Med. 3, 1445–1448 (2021). https://doi.org/10.1007/s42399-021-00848-w
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DOI: https://doi.org/10.1007/s42399-021-00848-w