日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
アルコール代謝とアンタブス作用の研究 第2報
藤原 榮一
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ジャーナル フリー

1954 年 50 巻 4 号 p. 402-409,en28

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The results of experiments with rabbits are as following : (1) Three per cent alcohol was injected in doses of 100 cc/ kg intraperitoneally to rabbits two weeks or more in succession until they became habituated to alcohol and the variation of the concentration of alcohol in blood was pursuited. In the habituated rabbits the *concentration of alcohol in blood became more rapidly high and decreased more quickly than that in the non-habituated rabbits. Its maximum concentration was higher in the habituated rabbits than that in the non-habituated ones. (2) The injection of alcohol subsequent to the administration of antabuse resulted in the very high concentration of alcohol in blood and the delay of alcohol metabolism in both the habituated and non-habituated rabbits. The concentration of alcohol in blood in the habituated rabbits, as compared with the one in the non-habituated ones lowered more quickly after it had once become high. (3) By the injection of alcohol only, the concentration of acetaldehyde in blood in the habituated rabbits, as compared to the one in the non-habituated ones, was more higher and fell off more quickly after it had gotten high. (4) When alcohol was injected-subsequently to the administration of antabuse into both the nonhabituated and the habituated rabbits, in the former the variation of the concentration, of acetaldehyde in blood scarcely differed with the one when only alcohol was given, but in the latter the concentration of acetaldehyde in blood increased remarkably, and acetaldehyde metabolism was delayed. (5) In the brain wave of the non-habituated rabbits the injection of alcohol induced disappearance of the fast wave and appearance of the prominent slow wave, this indicating the inhibitory effect of alcohol. The fast wave was apt to increase by the injection of alcohol as habituation of rabbits to alcohol proceeded. The brain wave of the nonhabituated rabbits which was obtained by the injection of alcohol subsequent to the administration of antabuse hardly differed with the one by the injection of alcohol only. In the brain wave of the habituated rabbits, on the contrary, the injection of alcohol after the administration of antabuse resulted in appearance of the fast wave in succession with intermittent spikes, to say the convulsive wave properly, this showing the significant effect of antabuse.

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