092 A Comparison of Baseline Erectile Function after On-Demand 20 mg Tadalafil vs Daily 5 mg Tadalafil in Men with Erectile Dysfunction and Diabetes: A Prospective, Observational 2-year Study

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Objectives

We studied whether long-term use of 5 mg tadalafil once daily improved baseline erectile function or prevented erectile dysfunction (ED) in men with diabetes.

Material and Methods

Men with ED and diabetes who were naïve to PDE5 inhibitors were assigned to 20 mg tadalafil on-demand or 5 mg tadalafil once daily and asked to provide information about erectile function at the start of treatment and after 2 years. When men completed the questionnaire after 2 years of treatment, they also stopped the medication for 4 weeks to check their baseline erectile function. The primary efficacy variable was the IIEF-EF score. Secondary efficacy variables included a change in the scores

Results

The study enrolled 118 men (mean age: 56.2yrs) and most had mild to moderate ED (57.6%): 65 patients (55.1%) were prescribed 20 mg tadalafil on demand and 53 patients (44.9%) took 5 mg tadalafil once daily. After 2 years of treatment, the daily treatment group had a significantly greater change in the IIEF-EF domain score from baseline compared with the on-demand group (7.3 vs 2.4, P < 0.0001). The changes in IIEF from baseline on Q3 (1.4 vs 0.4, P < 0.0001) and Q4 (1.4 vs 0.3, P < 0.0001) were

Conclusion

Long-term use of 5 mg tadalafil once daily was more beneficial for improving baseline erectile function or preventing ED than the on-demand pattern in men with ED and diabetes.

Disclosure

Work supported by industry: no.

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