Skip to main content

Advertisement

SpringerLink
Log in

Serum bisphenol A and progression of type 2 diabetic nephropathy: a 6-year prospective study

  • Original Article
  • Published:
Acta Diabetologica Aims and scope Submit manuscript

Abstract

Aims

Bisphenol A (BPA) is associated with diabetes and cardiovascular diseases. The aim of our study was to evaluate whether serum BPA could predict the progression of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D).

Methods

In this prospective study, a total of 121 patients with T2D and estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 were followed up for 6 years. The baseline values of serum BPA were measured. Renal function was measured as eGFR calculated by the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation. Development of CKD was defined as eGFR < 60 mL/min/1.73 m2 at the last follow-up. Regression models were used to analyze the associations of serum BPA with the change in eGFR and the risk of CKD development.

Results

Baseline serum BPA concentration was 0.40 (0.17, 1.40) ng/mL. Duration of T2D, baseline waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, and serum BPA level were significantly negatively associated with the annual change and percentage change in eGFR. After adjusting for clinical factors, baseline serum BPA level had a significant negative association with the annual change in eGFR (β = −0.371, P < 0.001) and percentage change in eGFR (β = −0.391, P = <0.001). Multivariate logistic regression analysis showed that patients with high levels of serum BPA exhibited about a sevenfold increased risk of developing CKD compared to patients with low levels of serum BPA [odds ratio (OR) 6.65 (95 % CI 1.47, 30.04), P = 0.014].

Conclusion

Serum BPA may be a predictor of CKD in patients with T2D.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Pugliese G (2014) Updating the natural history of diabetic nephropathy. Acta Diabetol 51(6):905–915

    Article  CAS  PubMed  Google Scholar 

  2. Rashid K, Sinha K, Sil PC (2013) An update on oxidative stress-mediated organ pathophysiology. Food Chem Toxicol 62:584–600

    Article  CAS  PubMed  Google Scholar 

  3. vom Saal FS, Welshons WV (2014) Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure. Mol Cell Endocrinol 398(1–2):101–113

    Article  CAS  PubMed  Google Scholar 

  4. You L, Zhu X, Shrubsole MJ, Fan H, Chen J, Dong J, Hao CM, Dai Q (2011) Renal function, bisphenol A, and alkylphenols: results from the National Health and Nutrition Examination Survey (NHANES 2003–2006). Environ Health Perspect 119(4):527–533

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Li M, Bi Y, Qi L, Wang T, Xu M, Huang Y, Xu Y, Chen Y, Lu J, Wang W, Ning G (2012) Exposure to bisphenol A is associated with low-grade albuminuria in Chinese adults. Kidney Int 81(11):1131–1139

    Article  CAS  PubMed  Google Scholar 

  6. Trasande L, Attina TM, Trachtman H (2013) Bisphenol A exposure is associated with low-grade urinary albumin excretion in children of the United States. Kidney Int 83(4):741–748

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Gonzalez-Parra E, Herrero JA, Elewa U, Bosch RJ, Arduan AO, Egido J (2013) Bisphenol a in chronic kidney disease. Int J Nephrol 2013:437857

    Article  PubMed Central  PubMed  Google Scholar 

  8. Aekplakorn W, Chailurkit LO, Ongphiphadhanakul B (2015) Relationship of serum bisphenol A with diabetes in the Thai population, National Health Examination Survey IV, 2009. J Diabetes 7(2):240–249

    Article  CAS  PubMed  Google Scholar 

  9. Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R, Khaw KT, Wareham NJ, Galloway TS (2012) Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation 125(12):1482–1490

    Article  CAS  PubMed  Google Scholar 

  10. Kandaraki E, Chatzigeorgiou A, Livadas S, Palioura E, Economou F, Koutsilieris M, Palimeri S, Panidis D, Diamanti-Kandarakis E (2011) Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. J Clin Endocrinol Metab 96(3):E480–E484

    Article  CAS  PubMed  Google Scholar 

  11. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS, Investigators C-E (2012) Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367(1):20–29

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Coresh J, Turin TC, Matsushita K, Sang Y, Ballew SH, Appel LJ, Arima H, Chadban SJ, Cirillo M, Djurdjev O, Green JA, Heine GH, Inker LA, Irie F, Ishani A, Ix JH, Kovesdy CP, Marks A, Ohkubo T, Shalev V, Shankar A, Wen CP, de Jong PE, Iseki K, Stengel B, Gansevoort RT, Levey AS, Consortium CKDP (2014) Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. JAMA 311(24):2518–2531

    Article  PubMed Central  PubMed  Google Scholar 

  13. Kim SS, Song SH, Kim IJ, Jeon YK, Kim BH, Kwak IS, Lee EK, Kim YK (2013) Urinary cystatin C and tubular proteinuria predict progression of diabetic nephropathy. Diabetes Care 36(3):656–661

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Rhee EP, Clish CB, Ghorbani A, Larson MG, Elmariah S, McCabe E, Yang Q, Cheng S, Pierce K, Deik A, Souza AL, Farrell L, Domos C, Yeh RW, Palacios I, Rosenfield K, Vasan RS, Florez JC, Wang TJ, Fox CS, Gerszten RE (2013) A combined epidemiologic and metabolomic approach improves CKD prediction. J Am Soc Nephrol 24(8):1330–1338

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Yildiz N, Barlas N (2013) Hepatic and renal functions in growing male rats after bisphenol A and octylphenol exposure. Hum Exp Toxicol 32(7):675–686

    Article  CAS  PubMed  Google Scholar 

  16. Olea-Herrero N, Arenas MI, Munoz-Moreno C, Moreno-Gomez-Toledano R, Gonzalez-Santander M, Arribas I, Bosch RJ (2014) Bisphenol-A induces podocytopathy with proteinuria in mice. J Cell Physiol 229(12):2057–2066

    Article  CAS  PubMed  Google Scholar 

  17. Shankar A, Teppala S, Sabanayagam C (2012) Bisphenol A and peripheral arterial disease: results from the NHANES. Environ Health Perspect 120(9):1297–1300

    Article  PubMed Central  PubMed  Google Scholar 

  18. Fan L, Levey AS, Gudnason V, Eiriksdottir G, Andresdottir MB, Gudmundsdottir H, Indridason OS, Palsson R, Mitchell G, Inker LA (2014) Comparing GFR estimating equations using cystatin C and creatinine in elderly individuals. J Am Soc Nephrol. doi:10.1681/ASN.2014060607

    Google Scholar 

  19. Vandenberg LN, Gerona RR, Kannan K, Taylor JA, van Breemen RB, Dickenson CA, Liao C, Yuan Y, Newbold RR, Padmanabhan V, Vom Saal FS, Woodruff TJ (2014) A round robin approach to the analysis of bisphenol A (BPA) in human blood samples. Environ Health 13(1):25. doi:10.1186/1476-069X-13-25

    Article  PubMed Central  PubMed  Google Scholar 

  20. Ohno M, Deguchi F, Izumi K, Ishigaki H, Sarui H, Sasaki A, Segawa T, Yamaki T, Kojima T, Ohashi H (2014) Correlation between renal function and common risk factors for chronic kidney disease in a healthy middle-aged population: a prospective observational 2-year study. PLoS One 9(11):e113263. doi:10.1371/journal.pone.0113263

    Article  PubMed Central  PubMed  Google Scholar 

  21. Pham H, Robinson-Cohen C, Biggs ML, Ix JH, Mukamal KJ, Fried LF, Kestenbaum B, Siscovick DS, de Boer IH (2012) Chronic kidney disease, insulin resistance, and incident diabetes in older adults. Clin J Am Soc Nephrol 7(4):588–594

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Zoccali C, Torino C, Tripepi G, Mallamaci F (2012) Assessment of obesity in chronic kidney disease: what is the best measure? Curr Opin Nephrol Hypertens 21(6):641–646

    Article  PubMed  Google Scholar 

  23. Evans PD, McIntyre NJ, Fluck RJ, McIntyre CW, Taal MW (2012) Anthropomorphic measurements that include central fat distribution are more closely related with key risk factors than BMI in CKD stage 3. PLoS One 7(4):e34699. doi:10.1371/journal.pone.0034699

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. Anjana RM, Shanthirani CS, Unnikrishnan R, Mugilan P, Amutha A, Nair HD, Subhashini S, Venkatesan U, Ali MK, Ranjani H, Mohan V (2015) Regularity of follow-up, glycemic burden, and risk of microvascular complications in patients with type 2 diabetes: a 9-year follow-up study. Acta Diabetol 52(3):601–609

    Article  CAS  PubMed  Google Scholar 

  25. Song Y, Hauser R, Hu FB, Franke AA, Liu S, Sun Q (2014) Urinary concentrations of bisphenol A and phthalate metabolites and weight change: a prospective investigation in US women. Int J Obes 38(12):1532–1537

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank Laboratory of Endocrine and Laboratory of Lipid and Glucose Metabolism, the First Affiliated Hospital of Chongqing Medical University. This research was supported by National Key Clinical Specialties Construction Program of China and National Natural Science Foundation of China Grants 81170751, 81370954, and 81200294. Qifu Li had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Author information

Authors and Affiliations

  1. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, Yuzhong District, Chongqing, 400016, China

    Jinbo Hu, Shumin Yang, Yue Wang, Richa Goswami, Chuan Peng, Rufei Gao, Huang Zhou, Qingfeng Cheng, Qianna Zhen & Qifu Li

  2. Hospital of Chongqing University, Chongqing, 400044, China

    Yi Zhang

Authors
  1. Jinbo Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shumin Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yue Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Richa Goswami
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chuan Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rufei Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Huang Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yi Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Qingfeng Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Qianna Zhen
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Qifu Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Qifu Li.

Ethics declarations

Conflict of interest

Jinbo Hu, Shumin Yang, Yue Wang, Richa Goswami, Chuan Peng, Rufei Gao, Huang Zhou, Yi Zhang, Qingfeng Cheng, Qianna Zhen, and Qifu Li declare that they have no conflict of interest.

Ethical standard

The ethical committee of the First Affiliated Hospital of Chongqing Medical University approved this study. All procedures followed were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.

Additional information

Managed by Massimo Porta.

Jinbo Hu and Shumin Yang are co-first authors.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hu, J., Yang, S., Wang, Y. et al. Serum bisphenol A and progression of type 2 diabetic nephropathy: a 6-year prospective study. Acta Diabetol 52, 1135–1141 (2015). https://doi.org/10.1007/s00592-015-0801-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00592-015-0801-5

Keywords

Search

Navigation